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Systematic reviews are crucial for evidence-based medicine as they comprehensively analyse published research findings on specific questions. Conducting such reviews is often resource- and time-intensive, especially in the screening phase,…

Information Retrieval · Computer Science 2024-02-02 Shuai Wang , Harrisen Scells , Shengyao Zhuang , Martin Potthast , Bevan Koopman , Guido Zuccon

Systematic reviews traditionally have taken considerable amounts of human time and energy to complete, in part due to the extensive number of titles and abstracts that must be reviewed for potential inclusion. Recently, researchers have…

Computation and Language · Computer Science 2026-03-27 Kweku Yamoah , Noah Schroeder , Emmanuel Dorley , Neha Rani , Caleb Schutz

Large Language Models (LLMs) are expected to significantly contribute to patient care, diagnostics, and administrative processes. Emerging biomedical LLMs aim to address healthcare-specific challenges, including privacy demands and…

Computation and Language · Computer Science 2025-10-14 Amin Dada , Marie Bauer , Amanda Butler Contreras , Osman Alperen Koraş , Constantin Marc Seibold , Kaleb E Smith , Jens Kleesiek

Large Language Models (LLMs), particularly those similar to ChatGPT, have significantly influenced the field of Natural Language Processing (NLP). While these models excel in general language tasks, their performance in domain-specific…

Computation and Language · Computer Science 2024-01-02 Omid Rohanian , Mohammadmahdi Nouriborji , David A. Clifton

Systematic reviews are comprehensive literature reviews that address highly focused research questions and represent the highest form of evidence in medicine. A critical step in this process is the development of complex Boolean queries to…

Information Retrieval · Computer Science 2025-06-03 Shuai Wang , Harrisen Scells , Bevan Koopman , Guido Zuccon

To enhance the performance of large language models (LLMs) in biomedical natural language processing (BioNLP) by introducing a domain-specific instruction dataset and examining its impact when combined with multi-task learning principles.…

Computation and Language · Computer Science 2024-06-10 Hieu Tran , Zhichao Yang , Zonghai Yao , Hong Yu

Systematic reviews are vital for guiding practice, research, and policy, yet they are often slow and labour-intensive. Large language models (LLMs) could offer a way to speed up and automate systematic reviews, but their performance in such…

Computation and Language · Computer Science 2024-04-11 Qusai Khraisha , Sophie Put , Johanna Kappenberg , Azza Warraitch , Kristin Hadfield

Objective: This study aims to summarize the usage of Large Language Models (LLMs) in the process of creating a scientific review. We look at the range of stages in a review that can be automated and assess the current state-of-the-art…

Digital Libraries · Computer Science 2025-05-16 Dmitry Scherbakov , Nina Hubig , Vinita Jansari , Alexander Bakumenko , Leslie A. Lenert

Large Language Models (LLMs) have shown promise in natural language processing tasks, with the potential to automate systematic reviews. This study evaluates the performance of three state-of-the-art LLMs in conducting systematic review…

Information Retrieval · Computer Science 2025-02-25 Xi Chen , Xue Zhang

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

This paper describes a rapid feasibility study of using GPT-4, a large language model (LLM), to (semi)automate data extraction in systematic reviews. Despite the recent surge of interest in LLMs there is still a lack of understanding of how…

Computation and Language · Computer Science 2025-02-14 Lena Schmidt , Kaitlyn Hair , Sergio Graziosi , Fiona Campbell , Claudia Kapp , Alireza Khanteymoori , Dawn Craig , Mark Engelbert , James Thomas

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

Large language models (LLMs) excel in tasks requiring processing and interpretation of input text. Abstract screening is a labour-intensive component of systematic review involving repetitive application of inclusion and exclusion criteria…

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

Open-source, multilingual medical large language models (LLMs) have the potential to serve linguistically diverse populations across different regions. Adapting generic LLMs for healthcare often requires continual pretraining, but this…

Computation and Language · Computer Science 2024-09-10 Meng Zhou , Surajsinh Parmar , Anubhav Bhatti

Proprietary Large Language Models (LLMs), such as ChatGPT, have garnered significant attention due to their exceptional capabilities in handling a diverse range of tasks. Recent studies demonstrate that open-sourced smaller foundational…

Computation and Language · Computer Science 2023-10-10 Yue Zhang , Leyang Cui , Deng Cai , Xinting Huang , Tao Fang , Wei Bi

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Objective: Most existing fine-tuned biomedical large language models (LLMs) focus on enhancing performance in monolingual biomedical question answering and conversation tasks. To investigate the effectiveness of the fine-tuned LLMs on…

This study investigated the application of Large Language Models (LLMs) for simplifying biomedical texts to enhance health literacy. Using a public dataset, which included plain language adaptations of biomedical abstracts, we developed and…

Computation and Language · Computer Science 2025-12-19 Primoz Kocbek , Leon Kopitar , Gregor Stiglic

Academic paper review typically requires substantial time, expertise, and human resources. Large Language Models (LLMs) present a promising method for automating the review process due to their extensive training data, broad knowledge base,…

Computers and Society · Computer Science 2025-06-24 Chuanlei Li , Xu Hu , Minghui Xu , Kun Li , Yue Zhang , Xiuzhen Cheng
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