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There is renewed interest in modeling and understanding the nervous system of the nematode $\textit{Caenorhabditis elegans}$ ($\textit{C. elegans}$), as this small model system provides a path to bridge the gap between nervous system…

Neurons and Cognition · Quantitative Biology 2025-05-20 Quilee Simeon , Anshul Kashyap , Konrad P Kording , Edward S Boyden

Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands…

Recent efforts in neuroscience research seek to obtain detailed anatomical neuronal wiring maps as well as information on how neurons in these networks engage in dynamic activities. Although the entire connectivity map of the nervous system…

Neurons and Cognition · Quantitative Biology 2014-06-09 Tina Schrödel , Robert Prevedel , Karin Aumayr , Manuel Zimmer , Alipasha Vaziri

An increasing body of evidence suggests that the trial-to-trial variability of spiking activity in the brain is not mere noise, but rather the reflection of a sampling-based encoding scheme for probabilistic computing. Since the precise…

To study information processing in the brain, neuroscientists manipulate experimental stimuli while recording participant brain activity. They can then use encoding models to find out which brain "zone" (e.g. which region of interest,…

Neurons and Cognition · Quantitative Biology 2022-02-22 Mariya Toneva , Jennifer Williams , Anand Bollu , Christoph Dann , Leila Wehbe

Living systems implement and execute an extraordinary plethora of computational tasks. The inherent degree of large scale coordination emerges as a global property, from the intricate sea of microscopic interactions. The brain, with its…

Disordered Systems and Neural Networks · Physics 2018-01-03 Duccio Fanelli , Francesco Ginelli , Roberto Livi , Niccolò Zagli , Clement Zankoc

We show that dynamical gain modulation of neurons' stimulus response is described as an information-theoretic cycle that generates entropy associated with the stimulus-related activity from entropy produced by the modulation. To articulate…

Neurons and Cognition · Quantitative Biology 2017-12-29 Hideaki Shimazaki

Self-adaptation has been proposed as a mechanism to counter complexity in control problems of technical systems. A major driver behind self-adaptation is the idea to transfer traditional design-time decisions to runtime and into the…

Multiagent Systems · Computer Science 2019-05-13 Stefan Rudolph , Sven Tomforde , Jörg Hähner

The 1mm roundworm C. elegans is a model organism used in many sub-areas of biology to investigate different types of biological processes. In order to complement the n-vivo analysis with computer-based investigations, several methods have…

Quantitative Methods · Quantitative Biology 2025-10-02 Nemanja Antonic , Monika Scholz , Aymeric Vellinger , Euphrasie Ramahefarivo , Elio Tuci

Understanding how information about external stimuli is transformed into behavior is one of the central goals of neuroscience. Here we characterize the information flow through a complete sensorimotor circuit: from stimulus, to sensory…

Neurons and Cognition · Quantitative Biology 2015-10-15 Eduardo J. Izquierdo , Paul L. Williams , Randall D. Beer

Neuroscientists have enjoyed much success in understanding brain functions by constructing brain connectivity networks using data collected under highly controlled experimental settings. However, these experimental settings bear little…

Machine Learning · Statistics 2019-06-24 Kean Ming Tan , Junwei Lu , Tong Zhang , Han Liu

Living systems, from single cells to higher vertebrates, receive a continuous stream of non-stationary inputs that they sense, e.g., via cell surface receptors or sensory organs. Integrating these time-varying, multi-sensory, and often…

Other Quantitative Biology · Quantitative Biology 2024-04-17 Daniel Koch , Akhilesh Nandan , Gayathri Ramesan , Aneta Koseska

Animals achieve sophisticated behavioral control through dynamic coupling of the brain, body, and environment. Accordingly, the co-design approach, in which both the controllers and the physical properties are optimized simultaneously, has…

Neural and Evolutionary Computing · Computer Science 2025-03-10 Hiroki Tomioka , Katsuma Inoue , Yasuo Kuniyoshi , Kohei Nakajima

Neurons in the brain continuously process the barrage of sensory inputs they receive from the environment. A wide array of experimental work has shown that the collective activity of neural populations encodes and processes this constant…

Neurons and Cognition · Quantitative Biology 2025-10-30 Siddharth Paliwal , Gabriel Koch Ocker , Braden A. W. Brinkman

Animal brains exhibit remarkable efficiency in perception and action, while being robust to both external and internal perturbations. The means by which brains accomplish this remains, for now, poorly understood, hindering our understanding…

Neurons and Cognition · Quantitative Biology 2026-03-11 André Urbano , Pablo Lanillos , Sander Keemink

Rapid advances in genetics, genomics, and imaging have given insight into the molecular and cellular basis of behaviour in a variety of model organisms with unprecedented detail and scope. It is increasingly routine to isolate behavioural…

Quantitative Methods · Quantitative Biology 2013-01-08 André E. X. Brown , William R. Schafer

Real-world complex systems such as ecological communities and neuron networks are essential parts of our everyday lives. These systems are composed of units which interact through intricate networks. The ability to predict sudden changes in…

Adaptation and Self-Organizing Systems · Physics 2019-07-05 Deniz Eroglu , Matteo Tanzi , Sebastian van Strien , Tiago Pereira

Metaphors of Computation and Information tended to detract attention from the intrinsic modes of neural system functions, uncontaminated by the observer's role for collection and interpretation of experimental data. Recognizing the…

General Physics · Physics 2011-07-21 Gerhard Werner

The study of the visual system of the brain has attracted the attention and interest of many neuro-scientists, that derived computational models of some types of neuron that compose it. These findings inspired researchers in image…

Computer Vision and Pattern Recognition · Computer Science 2021-03-03 Nicola Strisciuglio

Analogous to the mirror neuron system repeatedly described in monkeys as a possible substrate for imitation learning and/or action understanding, a neuronal execution/observation matching system (OEMS) is assumed in humans, but little is…

Neurons and Cognition · Quantitative Biology 2019-03-28 Markus Kern , Johanna Ruescher , Andreas Schulze-Bonhage , Tonio Ball