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Gene expression analysis aims at identifying the genes able to accurately predict biological parameters like, for example, disease subtyping or progression. While accurate prediction can be achieved by means of many different techniques,…

Methodology · Statistics 2008-09-11 Christine De Mol , Sofia Mosci , Magali Traskine , Alessandro Verri

This paper considers the power of deep neural networks (deep nets for short) in realizing data features. Based on refined covering number estimates, we find that, to realize some complex data features, deep nets can improve the performances…

Machine Learning · Computer Science 2019-01-03 Zheng-Chu Guo , Lei Shi , Shao-Bo Lin

We present an algorithm to generate synthetic datasets of tunable difficulty on classification of Morse code symbols for supervised machine learning problems, in particular, neural networks. The datasets are spatially one-dimensional and…

Machine Learning · Computer Science 2019-04-29 Sourya Dey , Keith M. Chugg , Peter A. Beerel

This study proposes a data condensation method for multivariate kernel density estimation by genetic algorithm. First, our proposed algorithm generates multiple subsamples of a given size with replacement from the original sample. The…

Methodology · Statistics 2022-03-04 Kiheiji Nishida

The rapid accumulation of Electronic Health Records (EHRs) has transformed healthcare by providing valuable data that enhance clinical predictions and diagnoses. While conventional machine learning models have proven effective, they often…

Interpretation of deep learning models is a very challenging problem because of their large number of parameters, complex connections between nodes, and unintelligible feature representations. Despite this, many view interpretability as a…

Machine Learning · Computer Science 2021-03-05 Michael Tsang , James Enouen , Yan Liu

Software systems are expansive, exhibiting behaviors characteristic of complex systems, such as self-organization and emergence. These systems, highlighted by advancements in Large Language Models (LLMs) and other AI applications developed…

Software Engineering · Computer Science 2025-04-01 Jan Žižka

In the deep-learning community new algorithms are published at an incredible pace. Therefore, solving an image classification problem for new datasets becomes a challenging task, as it requires to re-evaluate published algorithms and their…

Computer Vision and Pattern Recognition · Computer Science 2018-03-28 Florian Scheidegger , Roxana Istrate , Giovanni Mariani , Luca Benini , Costas Bekas , Cristiano Malossi

While various complexity measures for deep neural networks exist, specifying an appropriate measure capable of predicting and explaining generalization in deep networks has proven challenging. We propose Neural Complexity (NC), a…

Machine Learning · Computer Science 2020-10-26 Yoonho Lee , Juho Lee , Sung Ju Hwang , Eunho Yang , Seungjin Choi

Current machine learning has made great progress on computer vision and many other fields attributed to the large amount of high-quality training samples, while it does not work very well on genomic data analysis, since they are notoriously…

Machine Learning · Computer Science 2020-09-04 Ziyi Yang , Jun Shu , Yong Liang , Deyu Meng , Zongben Xu

Feature selection is a dimensionality reduction technique that selects a subset of representative features from high dimensional data by eliminating irrelevant and redundant features. Recently, feature selection combined with sparse…

Computer Vision and Pattern Recognition · Computer Science 2018-04-24 Siwei Feng , Marco F. Duarte

We propose a new type of entropic descriptor that is able to quantify the statistical complexity (a measure of complex behaviour) by taking simultaneously into account the average departures of a system's entropy S from both its maximum…

Statistical Mechanics · Physics 2015-05-13 R. Piasecki , A. Plastino

Many machine learning models have been proposed to classify phenotypes from gene expression data. In addition to their good performance, these models can potentially provide some understanding of phenotypes by extracting explanations for…

Genomics · Quantitative Biology 2024-02-05 Myriam Bontonou , Anaïs Haget , Maria Boulougouri , Benjamin Audit , Pierre Borgnat , Jean-Michel Arbona

Foundation model reliability assessment typically requires thousands of evaluation examples, making it computationally expensive and time-consuming for real-world deployment. We introduce microprobe, a novel approach that achieves…

Artificial Intelligence · Computer Science 2025-12-25 Aayam Bansal , Ishaan Gangwani

Microbiome data are complex in nature, involving high dimensionality, compositionally, zero inflation, and taxonomic hierarchy. Compositional data reside in a simplex that does not admit the standard Euclidean geometry. Most existing…

Methodology · Statistics 2020-11-12 Gen Li , Yan Li , Kun Chen

This article focuses on the supervised classification of datasets with a large number of variables and a small number of instances. This is the case, for example, for microarray data sets commonly used in bioinformatics. Complex classifiers…

Quantitative Methods · Quantitative Biology 2023-11-23 Pablo Torrijos , José A. Gámez , José M. Puerta

This work presents a new approach for classification of genomic sequences from measurements of complex networks and information theory. For this, it is considered the nucleotides, dinucleotides and trinucleotides of a genomic sequence. For…

Computational Engineering, Finance, and Science · Computer Science 2014-12-19 Bruno Mendes Moro Conque , André Yoshiaki Kashiwabara , Fabrício Martins Lopes

A key task of data science is to identify relevant features linked to certain output variables that are supposed to be modeled or predicted. To obtain a small but meaningful model, it is important to find stochastically independent…

Methodology · Statistics 2021-12-23 Tim Breitenbach , Lauritz Rasbach , Chunguang Liang , Patrick Jahnke

Deep neural networks exhibit a simplicity bias, a well-documented tendency to favor simple functions over complex ones. In this work, we cast new light on this phenomenon through the lens of the Minimum Description Length principle,…

Deep generative models open new avenues for simulating realistic genomic data while preserving privacy and addressing data accessibility constraints. While previous studies have primarily focused on generating gene expression or haplotype…

Genomics · Quantitative Biology 2025-08-14 Sihan Xie , Thierry Tribout , Didier Boichard , Blaise Hanczar , Julien Chiquet , Eric Barrey