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Neural prediction offers a promising approach to forecasting the individual variability of neurocognitive functions and disorders and providing prognostic indicators for personalized invention. However, it is challenging to translate neural…

Machine Learning · Computer Science 2025-12-02 Yanlin Wang , Nancy M Young , Patrick C M Wong

Directed evolution as a widely-used engineering strategy faces obstacles in finding desired mutants from the massive size of candidate modifications. While deep learning methods learn protein contexts to establish feasible searching space,…

Quantitative Methods · Quantitative Biology 2023-04-18 Bingxin Zhou , Outongyi Lv , Kai Yi , Xinye Xiong , Pan Tan , Liang Hong , Yu Guang Wang

A while ago, the ideas of evolutionary biology inspired computer scientists to develop a thriving nowadays field of evolutionary computation (EC), in general, and genetic algorithms (GA), in particular. At the same time, the directed…

Quantitative Methods · Quantitative Biology 2019-12-09 Alexander Spirov , Ekaterina Myasnikova

Dynamic Optimization Problems (DOPs) are challenging to address due to their complex nature, i.e., dynamic environment variation. Evolutionary Computation methods are generally advantaged in solving DOPs since they resemble dynamic…

Neural and Evolutionary Computing · Computer Science 2026-02-02 Zijian Gao , Yuanting Zhong , Zeyuan Ma , Yue-Jiao Gong , Hongshu Guo

The data-driven models allow one to define the model structure in cases when a priori information is not sufficient to build other types of models. The possible way to obtain physical interpretation is the data-driven differential equation…

Neural and Evolutionary Computing · Computer Science 2019-06-11 Michail Maslyaev , Alexander Hvatov , Anna Kalyuzhnaya

A computational revolution unleashed the power of artificial neural networks. At the heart of that revolution is automatic differentiation, which calculates the derivative of a performance measure relative to a large number of parameters.…

Quantitative Methods · Quantitative Biology 2023-12-27 Steven A. Frank

We survey some of our recent results on inverse problems for evolution equations. The goal is to provide a unified approach to solve various types of evolution equations. The inverse problems we consider consist in determining unknown…

Analysis of PDEs · Mathematics 2019-12-09 Kaïs Ammari , Mourad Choulli , Faouzi Triki

We present a framework for recovering/approximating unknown time-dependent partial differential equation (PDE) using its solution data. Instead of identifying the terms in the underlying PDE, we seek to approximate the evolution operator of…

Numerical Analysis · Mathematics 2020-05-05 Kailiang Wu , Dongbin Xiu

In the last decade, the scientific community has devolved its attention to the deployment of data-driven approaches in scientific research to provide accurate and reliable analysis of a plethora of phenomena. Most notably, Physics-informed…

Machine Learning · Computer Science 2023-06-21 Mattia Silvestri , Federico Baldo , Eleonora Misino , Michele Lombardi

This research is concerned with evolution equations and their forward-backward discretizations. Our first contribution is an estimation for the distance between iterates of sequences generated by forward-backward schemes, useful in the…

Optimization and Control · Mathematics 2019-12-16 Andres Contreras , Juan Peypouquet

Variational quantum circuits have arisen as an important method in quantum computing. A crucial step of it is parameter optimization, which is typically tackled through gradient-descent techniques. We advantageously explore instead the use…

Quantum Physics · Physics 2024-12-24 Vignesh Anantharamakrishnan , Márcio M. Taddei

Evolutionary computation offers a variety of tools to solve complex real-world optimization problems. However, research often focuses on smaller, simplified problems and optimization algorithms that sometimes miss expectations in real-world…

A method for finding exact solutions of nonlinear differential equations is presented. Our method is based on the application of the Newton polygons corresponding to nonlinear differential equations. It allows one to express exact solutions…

Exactly Solvable and Integrable Systems · Physics 2007-05-23 Nikolai A. Kudryashov , Maria V. Demina

Differential evolution is one of the most prestigious population-based stochastic optimization algorithm for black-box problems. The performance of a differential evolution algorithm depends highly on its mutation and crossover strategy and…

Neural and Evolutionary Computing · Computer Science 2021-02-09 Jianyong Sun , Xin Liu , Thomas Bäck , Zongben Xu

The Wei-Norman technique allows to express the solution of a system of linear non-autonomous differential equations in terms of product of exponentials. In particular it enables to find a time-ordered product of exponentials by solving a…

Classical Analysis and ODEs · Mathematics 2013-12-19 Szymon Charzyński , Marek Kuś

Directed evolution of proteins has been the most effective method for protein engineering. However, a new paradigm is emerging, fusing the library generation and screening approaches of traditional directed evolution with computation…

Biomolecules · Quantitative Biology 2023-05-29 Kadina E. Johnston , Clara Fannjiang , Bruce J. Wittmann , Brian L. Hie , Kevin K. Yang , Zachary Wu

Evolutionary computation techniques have mostly been used to solve various optimization and learning problems successfully. Evolutionary algorithm is more effective to gain optimal solution(s) to solve complex problems than traditional…

Neural and Evolutionary Computing · Computer Science 2013-03-05 Moslema Jahan , M. M. A. Hashem , Gazi Abdullah Shahriar

Many applications in machine learning require optimizing a function whose true gradient is unknown, but where surrogate gradient information (directions that may be correlated with, but not necessarily identical to, the true gradient) is…

Neural and Evolutionary Computing · Computer Science 2019-06-12 Niru Maheswaranathan , Luke Metz , George Tucker , Dami Choi , Jascha Sohl-Dickstein

Differential Evolution (DE) proved to be one of the most successful evolutionary algorithms for global optimization purposes in continuous problems. The core operator in DE is mutation which can provide the algorithm with both exploration…

Neural and Evolutionary Computing · Computer Science 2016-04-12 H. Sharifi Noghabi , H. Rajabi Mashhadi , K. Shojaei

This paper introduces neuroevolution for solving differential equations. The solution is obtained through optimizing a deep neural network whose loss function is defined by the residual terms from the differential equations. Recent studies…

Neural and Evolutionary Computing · Computer Science 2021-05-06 Jian Cheng Wong , Abhishek Gupta , Yew-Soon Ong