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We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic

Each human genome is a 3 billion base pair set of encoding instructions. Decoding the genome using deep learning fundamentally differs from most tasks, as we do not know the full structure of the data and therefore cannot design…

Machine Learning · Computer Science 2016-05-24 Laura Deming , Sasha Targ , Nate Sauder , Diogo Almeida , Chun Jimmie Ye

Optimizing the mRNA codon has an essential impact on gene expression for a specific target protein. It is an NP-hard problem; thus, exact solutions to such optimization problems become computationally intractable for realistic problem sizes…

Quantum Physics · Physics 2024-05-13 Hongfeng Zhang , Aritra Sarkar , Koen Bertels

Quantum computers hold great promise for accelerating computationally challenging algorithms on noisy intermediate-scale quantum (NISQ) devices in the upcoming years. Much attention of the current research is directed to algorithmic…

We present a genetic algorithm for finding a set of pulse sequences, or rotations, for a given quantum logic gate, as implemented by NMR. We demonstrate the utility of the method by showing that shorter sequences than have been previously…

Quantum Physics · Physics 2012-07-31 M. J. Rethinam , A. K. Javali , E. C. Behrman , J. E. Steck , S. R. Skinner

Due to its longevity and enormous information density, DNA is an attractive medium for archival data storage. Thanks to rapid technological advances, DNA storage is becoming practically feasible, as demonstrated by a number of experimental…

Information Theory · Computer Science 2022-11-11 Ilan Shomorony , Reinhard Heckel

DNA sequencing is the physical/biochemical process of identifying the location of the four bases (Adenine, Guanine, Cytosine, Thymine) in a DNA strand. As semiconductor technology revolutionized computing, modern DNA sequencing technology…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-06 S. Karen Khatamifard , Zamshed Chowdhury , Nakul Pande , Meisam Razaviyayn , Chris Kim , Ulya R. Karpuzcu

Quantum computing, leveraging quantum phenomena like superposition and entanglement, is emerging as a transformative force in computing technology, promising unparalleled computational speed and efficiency crucial for engineering…

Quantum Physics · Physics 2024-08-30 Osama Muhammad Raisuddin , Suvranu De

Quantum computers are gaining importance in various applications like quantum machine learning and quantum signal processing. These applications face significant challenges in loading classical datasets into quantum memory. With numerous…

Quantum Physics · Physics 2025-01-14 Andriy Miranskyy , Mushahid Khan , Udson Mendes

Recent advances in DNA sequencing open prospects to make whole-genome analysis rapid and reliable, which is promising for various applications including personalized medicine. However, existing techniques for {\it de novo} genome assembly,…

We propose a hybrid classical-quantum digitized-counterdiabatic algorithm to tackle the protein folding problem on a tetrahedral lattice. Digitized-counterdiabatic quantum computing is a paradigm developed to compress quantum algorithms via…

Quantum Physics · Physics 2023-07-13 Pranav Chandarana , Narendra N. Hegade , Iraitz Montalban , Enrique Solano , Xi Chen

With current hardware and software, a standard computer can now hold in RAM an index for approximate pattern matching on about half a dozen human genomes. Sequencing technologies have improved so quickly, however, that scientists will soon…

Data Structures and Algorithms · Computer Science 2013-07-25 Hector Ferrada , Travis Gagie , Tommi Hirvola , Simon J. Puglisi

The yearly global production of data is growing exponentially, outpacing the capacity of existing storage media, such as tape and disk, and surpassing our ability to store it. DNA storage - the representation of arbitrary information as…

Quantitative Methods · Quantitative Biology 2023-10-04 Thomas Heinis , Roman Sokolovskii , Jamie J. Alnasir

Recent studies have been spurred on by the promise of advanced quantum computing technology, which has led to the development of quantum computer simulations on classical hardware. Grover's quantum search algorithm is one of the well-known…

Given two unsorted lists each of length N that have a single common entry, a quantum computer can find that matching element with a work factor of $O(N^{3/4}\log N)$ (measured in quantum memory accesses and accesses to each list). The…

Quantum Physics · Physics 2007-05-23 Mark Heiligman

Distributed Quantum Computing (DQC) provides a means for scaling available quantum computation by interconnecting multiple quantum processor units (QPUs). A key challenge in this domain is efficiently allocating logical qubits from quantum…

One of the most basic computational problems is the task of finding a desired item in an ordered list of N items. While the best classical algorithm for this problem uses log_2 N queries to the list, a quantum computer can solve the problem…

Quantum Physics · Physics 2007-05-23 Andrew M. Childs , Andrew J. Landahl , Pablo A. Parrilo

A central task in the field of quantum computing is to find applications where quantum computer could provide exponential speedup over any classical computer. Machine learning represents an important field with broad applications where…

Quantum Physics · Physics 2017-11-07 Xun Gao , Zhengyu Zhang , Luming Duan

We propose two quantum algorithms for a problem in bioinformatics, position weight matrix (PWM) matching, which aims to find segments (sequence motifs) in a biological sequence such as DNA and protein that have high scores defined by the…

Quantum Physics · Physics 2023-03-08 Koichi Miyamoto , Naoki Yamamoto , Yasubumi Sakakibara

In the context of evolutionary quantum computing in the literal meaning, a quantum crossover operation has not been introduced so far. Here, we introduce a novel quantum genetic algorithm which has a quantum crossover procedure performing…

Neural and Evolutionary Computing · Computer Science 2014-02-05 Akira SaiToh , Robabeh Rahimi , Mikio Nakahara
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