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Variational quantum algorithms are believed to be promising for solving computationally hard problems and are often comprised of repeated layers of quantum gates. An example thereof is the quantum approximate optimization algorithm (QAOA),…

Quantum computers are expected to accelerate solving combinatorial optimization problems, including algorithms such as Grover adaptive search and quantum approximate optimization algorithm (QAOA). However, many combinatorial optimization…

Quantum Physics · Physics 2023-05-05 Takuya Yoshioka , Keita Sasada , Yuichiro Nakano , Keisuke Fujii

Transportation systems such as urban logistics, vehicle routing, and infrastructure planning require solving large-scale combinatorial optimization problems under complex constraints. Problems such as the vehicle routing problem (VRP),…

Quantum Physics · Physics 2026-04-30 Talha Azfar , Ruimin Ke , Sean He , Cara Wang , José Holguín-Veras

Quantum computing is an emerging field on the multidisciplinary interface between physics, engineering, and computer science with the potential to make a large impact on computational intelligence (CI). The aim of this paper is to introduce…

In the wake of quantum computing advancements and quantum algorithmic progress, quantum algorithms are increasingly being employed to address a myriad of combinatorial optimization problems. Among these, the Independent Domination Problem…

Quantum Physics · Physics 2024-12-31 Haoqian Pan , Changhong Lu

Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

Recent advances in quantum computing and the increasing availability of quantum hardware have substantially enhanced the practical relevance of quantum approaches to discrete optimization. Among these, the Quadratic Unconstrained Binary…

Quantum Physics · Physics 2026-02-12 Felix P. Broesamle , Stefan Nickel

Quantum Approximate Optimization Algorithm (QAOA) is one of the most promising quantum algorithms for the Noisy Intermediate-Scale Quantum (NISQ) era. Quantifying the performance of QAOA in the near-term regime is of utmost importance. We…

Quantum Physics · Physics 2022-06-16 Ruslan Shaydulin , Yuri Alexeev

Quantum approximate optimization algorithm (QAOA) is one of the popular quantum algorithms that are used to solve combinatorial optimization problems via approximations. QAOA is able to be evaluated on both physical and virtual quantum…

Quantum Physics · Physics 2023-12-07 Yu-Cheng Lin , Chuan-Chi Wang , Chia-Heng Tu , Shih-Hao Hung

The design of fast algorithms for combinatorial optimization greatly contributes to a plethora of domains such as logistics, finance, and chemistry. Quantum approximate optimization algorithms (QAOAs), which utilize the power of quantum…

Quantum Physics · Physics 2022-05-25 Zeqiao Zhou , Yuxuan Du , Xinmei Tian , Dacheng Tao

The Quantum Approximate Optimization Algorithm and its generalization to Quantum Alternating Operator Ansatz (QAOA) is a promising approach for applying quantum computers to challenging problems such as combinatorial optimization and…

Quantum Physics · Physics 2023-07-25 Vladimir Kremenetski , Anuj Apte , Tad Hogg , Stuart Hadfield , Norm M. Tubman

This article consists of a short introduction to the quantum approximation optimisation algorithm (QAOA). The mathematical structure of the QAOA, as well as its basic properties, are described. The implementation of the QAOA on MaxCut…

Quantum Physics · Physics 2021-03-25 Behzad Mansouri

Motivated by the recent advancement of quantum processors, we investigate quantum approximate optimization algorithm (QAOA) to employ quasi-maximum-likelihood (ML) decoding of classical channel codes. QAOA is a hybrid quantum-classical…

Information Theory · Computer Science 2019-03-07 Toshiki Matsumine , Toshiaki Koike-Akino , Ye Wang

The Quantum Approximate Optimization Algorithm (QAOA) is a general-purpose algorithm for combinatorial optimization problems whose performance can only improve with the number of layers $p$. While QAOA holds promise as an algorithm that can…

Quantum Physics · Physics 2022-07-08 Edward Farhi , Jeffrey Goldstone , Sam Gutmann , Leo Zhou

Combinatorial optimization is a promising area for achieving quantum speedup. Quantum approximate optimization algorithm (QAOA) is designed to search for low-energy states of the Ising model, which correspond to near-optimal solutions of…

Quantum Physics · Physics 2025-10-14 Tatsuhiko Shirai , Nozomu Togawa

In drug discovery, molecular docking is the task in charge of estimating the position of a molecule when interacting with the docking site. This task is usually used to perform screening of a large library of molecules, in the early phase…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-01-21 Emanuele Vitali , Davide Gadioli , Gianluca Palermo , Andrea Beccari , Carlo Cavazzoni , Cristina Silvano

The Quantum Approximate Optimization Algorithm (QAOA) is a highly promising variational quantum algorithm that aims to solve combinatorial optimization problems that are classically intractable. This comprehensive review offers an overview…

The Quantum Approximate Optimization Algorithm (QAOA) is a promising algorithm for solving combinatorial optimization problems (COPs), with performance governed by variational parameters $\{\gamma_i, \beta_i\}_{i=0}^{p-1}$. While most prior…

Quantum Physics · Physics 2025-08-07 J. A. Montanez-Barrera , Kristel Michielsen

The quantum approximate optimization algorithm (QAOA) is a hybrid quantum-classical variational algorithm that offers the potential to handle combinatorial optimization problems. Introducing constraints in such combinatorial optimization…

Quantum Physics · Physics 2021-12-15 Santosh Kumar Radha

The quantum approximate optimization algorithm (QAOA) is a leading variational approach to combinatorial optimization, but its practical performance depends strongly on objective design, parameter search, and shot allocation. We present a…

Quantum Physics · Physics 2026-04-09 Siran Zhang , Shuming Cheng