Related papers: The role of APOBEC3-induced mutations in the diffe…
The human genome encodes a family of editing enzymes known as APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3). Several family members, such as APO-BEC3G, APOBEC3F, and APOBEC3H haplotype II, exhibit activity…
Background: Although the outbreak of human monkeypox (mpox) caused by the monkeypox virus (MPXV) has slowed down around the world, little is known about the short-term dynamics of this disease. This limited information highlights the…
Monkeypox virus (MPXV) is a zoonotic virus that poses a significant threat to public health, particularly in remote parts of Central and West Africa. Early detection of monkeypox lesions is crucial for effective treatment. However, due to…
Self-supervised pre-training methods have brought remarkable breakthroughs in the understanding of text, image, and speech. Recent developments in genomics has also adopted these pre-training methods for genome understanding. However, they…
Objectives The review is dedicated to evaluate the current monkeypox virus (MPXV) detection methods, discuss their pros and cons, and provide recommended solutions to the problems. Methods The literature for this review is identified…
Deleterious genetic variants can be evaluated as quantitative traits using information theory-based sequence analysis of recognition sites. To assess the effect of such variants, fitness and genetic load of SNPs which alter binding site…
About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single generation. MNMs have the potential to accelerate the pace at…
Since mpox can spread from person to person, it is a zoonotic viral illness that poses a significant public health concern. It is difficult to make an early clinical diagnosis because of how closely its symptoms match those of measles and…
The phenotypic consequences of individual mutations are modulated by the wild type genetic background in which they occur.Although such background dependence is widely observed, we do not know whether general patterns across species and…
Monkeypox (MPox) is a zoonotic infectious disease induced by the MPox Virus, part of the poxviridae orthopoxvirus group initially discovered in Africa and gained global attention in mid-2022 with cases reported outside endemic areas.…
Joint quantification of genetic and epigenetic effects on gene expression is important for understanding the establishment of complex gene regulation systems in living organisms. In particular, genomic imprinting and maternal effects play…
The editing of transcribed RNA by other molecules such that the form of the final product differs from that specified in the corresponding DNA sequence is ubiquitous. This paper uses an abstract, tunable Boolean genetic regulatory network…
As a living information and communications system, the genome encodes patterns in single nucleotide polymorphisms (SNPs) reflecting human adaption that optimizes population survival in differing environments. This paper mathematically…
The single nucleotide polymorphism (SNP) is the most widely studied type of genetic variation. A haplotype is defined as the sequence of alleles at SNP sites on each haploid chromosome. Haplotype information is essential in unravelling the…
Apolipoprotein E (ApoE) gene variations are involved in lipid metabolism and cholesterol transport, with the ApoE4 allele being a known risk factor associated with neurodegenerative conditions later in life. Emerging evidence suggests these…
Monkeypox virus is emerging slowly with the decline of COVID-19 virus infections around the world. People are afraid of it, thinking that it would appear as a pandemic like COVID-19. As such, it is crucial to detect them earlier before…
Background: DNA, RNA, and protein sequence motifs can be recognition sites for biological functions such as regulation, DNA base modification, and molecular binding in general. The gain and loss of such motifs can carry important…
A multi-species generalization of the asymmetric simple exclusion process (ASEP) is studied in ordered sequential and sub-lattice parallel updating schemes. In this model particles hop with their own specific probabilities to their…
Various studies have shown an association between single nucleotide polymorphisms (SNPs) and common disease. We hypothesize that information encoded in the structure of SNP haploblock variation illumines molecular pathways and cellular…
The transmission of monkeypox is studied using a stochastic model taking into account the biological aspects, the contact mechanisms and the demographic factors together with the intrinsic uncertainties. Our results provide insight into the…