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Domain adaptation is a widely used method in natural language processing (NLP) to improve the performance of a language model within a specific domain. This method is particularly common in the biomedical domain, which sees regular…

Computation and Language · Computer Science 2024-09-05 Mathieu Laï-king , Patrick Paroubek

Natural language processing (NLP) of clinical trial documents can be useful in new trial design. Here we identify entity types relevant to clinical trial design and propose a framework called CT-BERT for information extraction from clinical…

Quantitative Methods · Quantitative Biology 2021-10-20 Xiong Liu , Greg L. Hersch , Iya Khalil , Murthy Devarakonda

Contextualized word embeddings derived from pre-trained language models (LMs) show significant improvements on downstream NLP tasks. Pre-training on domain-specific corpora, such as biomedical articles, further improves their performance.…

Computation and Language · Computer Science 2019-04-05 Qiao Jin , Bhuwan Dhingra , William W. Cohen , Xinghua Lu

State-of-the-art models for relation extraction (RE) in the biomedical domain consider finetuning BioBERT using classification, but they may suffer from the anisotropy problem. Contrastive learning methods can reduce this anisotropy…

Computation and Language · Computer Science 2024-11-01 Farshad Noravesh

As a major social media platform, Twitter publishes a large number of user-generated text (tweets) on a daily basis. Mining such data can be used to address important social, public health, and emergency management issues that are…

Computation and Language · Computer Science 2021-12-07 Qing Han , Shubo Tian , Jinfeng Zhang

Objective: This study quantifies the capabilities of GPT-3.5 and GPT-4 for clinical named entity recognition (NER) tasks and proposes task-specific prompts to improve their performance. Materials and Methods: We evaluated these models on…

Computation and Language · Computer Science 2024-01-26 Yan Hu , Qingyu Chen , Jingcheng Du , Xueqing Peng , Vipina Kuttichi Keloth , Xu Zuo , Yujia Zhou , Zehan Li , Xiaoqian Jiang , Zhiyong Lu , Kirk Roberts , Hua Xu

Genome-wide association studies have proven to be essential for understanding the genetic basis of disease. However, many complex traits---personality traits, facial features, disease subtyping---are inherently high-dimensional, impeding…

Applications · Statistics 2015-12-09 Ashlee Valente , Geoffrey Ginsburg , Barbara E Engelhardt

Effective biomedical literature retrieval (BLR) plays a central role in precision medicine informatics. In this paper, we propose GRAPHENE, which is a deep learning based framework for precise BLR. GRAPHENE consists of three main different…

Information Retrieval · Computer Science 2019-11-22 Sendong Zhao , Chang Su , Andrea Sboner , Fei Wang

Discovering genes with similar functions across diverse biomedical contexts poses a significant challenge in gene representation learning due to data heterogeneity. In this study, we resolve this problem by introducing a novel model called…

Machine Learning · Computer Science 2023-10-05 Tianyu Liu , Yuge Wang , Rex Ying , Hongyu Zhao

OBJECTIVE: Leverage existing biomedical NLP tools and DS domain terminology to produce a novel and comprehensive knowledge graph containing dietary supplement (DS) information for discovering interactions between DS and drugs, or…

We introduce SpERT, an attention model for span-based joint entity and relation extraction. Our key contribution is a light-weight reasoning on BERT embeddings, which features entity recognition and filtering, as well as relation…

Computation and Language · Computer Science 2021-06-30 Markus Eberts , Adrian Ulges

The injection of domain-specific knowledge is crucial for adapting language models (LMs) to specialized fields such as biomedicine. While most current approaches rely on unstructured text corpora, this study explores two complementary…

Computation and Language · Computer Science 2026-04-21 Jaafer Klila , Sondes Bannour Souihi , Rahma Boujelben , Nasredine Semmar , Lamia Hadrich Belguith

Synthesizing medical images, such as PET, is a challenging task due to the fact that the intensity range is much wider and denser than those in photographs and digital renderings and are often heavily biased toward zero. Above all,…

Biomedical named entity recognition (BNER) serves as the foundation for numerous biomedical text mining tasks. Unlike general NER, BNER require a comprehensive grasp of the domain, and incorporating external knowledge beyond training data…

Computation and Language · Computer Science 2023-07-06 Junyi Bian , Rongze Jiang , Weiqi Zhai , Tianyang Huang , Hong Zhou , Shanfeng Zhu

Medication Extraction and Mining play an important role in healthcare NLP research due to its practical applications in hospital settings, such as their mapping into standard clinical knowledge bases (SNOMED-CT, BNF, etc.). In this work, we…

Computation and Language · Computer Science 2024-12-31 Pablo Romero , Lifeng Han , Goran Nenadic

Background: Finding biomedical named entities is one of the most essential tasks in biomedical text mining. Recently, deep learning-based approaches have been applied to biomedical named entity recognition (BioNER) and showed promising…

Computation and Language · Computer Science 2019-05-30 Wonjin Yoon , Chan Ho So , Jinhyuk Lee , Jaewoo Kang

The paper utilizes the graph embeddings generated for entities of a large biomedical database to perform link prediction to capture various new relationships among different entities. A novel node similarity measure is proposed that…

Information Retrieval · Computer Science 2021-11-01 Prakhar Gurawa , Matthias Nickles

Because protein-protein interactions (PPIs) are crucial to understand living systems, harvesting these data is essential to probe disease development and discern gene/protein functions and biological processes. Some curated datasets contain…

Biomolecules · Quantitative Biology 2024-03-12 Gilchan Park , Sean McCorkle , Carlos Soto , Ian Blaby , Shinjae Yoo

Machine learning methods have recently achieved high-performance in biomedical text analysis. However, a major bottleneck in the widespread application of these methods is obtaining the required large amounts of annotated training data,…

Machine Learning · Computer Science 2019-12-06 Xing Meng , Craig H. Ganoe , Ryan T. Sieberg , Yvonne Y. Cheung , Saeed Hassanpour

A panel of large number of common Single Nucleotide Polymorphisms (SNPs) distributed across an entire porcine genome has been widely used to represent genetic variability of pig. With the advent of SNP-array technology, a genome-wide…

Quantitative Methods · Quantitative Biology 2025-02-06 Wanthanee Rathasamuth , Kitsuchart Pasupa , Sissades Tongsima