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Deep Learning in Image Registration (DLIR) methods have been tremendously successful in image registration due to their speed and ability to incorporate weak label supervision at training time. However, existing DLIR methods forego many of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Rohit Jena , Pratik Chaudhari , James C. Gee

Image registration is fundamental in medical imaging applications, such as disease progression analysis or radiation therapy planning. The primary objective of image registration is to precisely capture the deformation between two or more…

Image and Video Processing · Electrical Eng. & Systems 2024-12-23 Anna Reithmeir , Veronika Spieker , Vasiliki Sideri-Lampretsa , Daniel Rueckert , Julia A. Schnabel , Veronika A. Zimmer

Multimodal deep learning has been used to predict clinical endpoints and diagnoses from clinical routine data. However, these models suffer from scaling issues: they have to learn pairwise interactions between each piece of information in…

Explaining Deep Learning models is becoming increasingly important in the face of daily emerging multimodal models, particularly in safety-critical domains like medical imaging. However, the lack of detailed investigations into the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-29 Anees Ur Rehman Hashmi , Dwarikanath Mahapatra , Mohammad Yaqub

Medical imaging is playing a more and more important role in clinics. However, there are several issues in different imaging modalities such as slow imaging speed in MRI, radiation injury in CT and PET. Therefore, accelerating MRI, reducing…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Jing Cheng , Haifeng Wang , Yanjie Zhu , Qiegen Liu , Qiyang Zhang , Ting Su , Jianwei Chen , Yongshuai Ge , Zhanli Hu , Xin Liu , Hairong Zheng , Leslie Ying , Dong Liang

The correlation of optical measurements with a correct pathology label is often hampered by imprecise registration caused by deformations in histology images. This study explores an automated multi-modal image registration technique…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Lianne Feenstra , Maud Lambregts , Theo J. M Ruers , Behdad Dashtbozorg

Image registration is a key technique in medical image analysis to estimate deformations between image pairs. A good deformation model is important for high-quality estimates. However, most existing approaches use ad-hoc deformation models…

Computer Vision and Pattern Recognition · Computer Science 2019-04-23 Marc Niethammer , Roland Kwitt , Francois-Xavier Vialard

Medical image segmentation is vital for modern healthcare and is a key element of computer-aided diagnosis. While recent advancements in computer vision have explored unsupervised segmentation using pre-trained models, these methods have…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Mosong Ma , Tania Stathaki , Michalis Lazarou

Supervised Deep-Learning (DL)-based reconstruction algorithms have shown state-of-the-art results for highly-undersampled dynamic Magnetic Resonance Imaging (MRI) reconstruction. However, the requirement of excessive high-quality…

Image and Video Processing · Electrical Eng. & Systems 2025-11-11 Jie Feng , Ruimin Feng , Qing Wu , Zhiyong Zhang , Yuyao Zhang , Hongjiang Wei

Deep learning-based image processing is capable of creating highly appealing results. However, it is still widely considered as a "blackbox" transformation. In medical imaging, this lack of comprehensibility of the results is a sensitive…

Image and Video Processing · Electrical Eng. & Systems 2020-05-29 Bernhard Stimpel , Christopher Syben , Franziska Schirrmacher , Philipp Hoelter , Arnd Dörfler , Andreas Maier

Magnetic Resonance Imaging is a critical imaging modality in clinical diagnosis and research, yet its complexity and heterogeneity hinder scalable, generalizable machine learning. Although foundation models have revolutionized language and…

The increasing availability of large collections of electronic health record (EHR) data and unprecedented technical advances in deep learning (DL) have sparked a surge of research interest in developing DL based clinical decision support…

Machine Learning · Computer Science 2021-12-07 Di Jin , Elena Sergeeva , Wei-Hung Weng , Geeticka Chauhan , Peter Szolovits

The development of magnetic resonance imaging (MRI) for medical imaging has provided a leap forward in diagnosis, providing a safe, non-invasive alternative to techniques involving ionising radiation exposure for diagnostic purposes. It was…

Image and Video Processing · Electrical Eng. & Systems 2024-07-02 Ana Carolina Alves , André Ferreira , Behrus Puladi , Jan Egger , Victor Alves

Explainability of deep neural networks is one of the most challenging and interesting problems in the field. In this study, we investigate the topic focusing on the interpretability of deep learning-based registration methods. In…

Deep learning has driven significant advances in medical image analysis, yet its adoption in clinical practice remains constrained by the large size and lack of transparency in modern models. Advances in interpretability techniques such as…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Nikita Malik , Pratinav Seth , Neeraj Kumar Singh , Chintan Chitroda , Vinay Kumar Sankarapu

Interpretability for machine learning models in medical imaging (MLMI) is an important direction of research. However, there is a general sense of murkiness in what interpretability means. Why does the need for interpretability in MLMI…

Machine Learning · Computer Science 2024-04-17 Alan Q. Wang , Batuhan K. Karaman , Heejong Kim , Jacob Rosenthal , Rachit Saluja , Sean I. Young , Mert R. Sabuncu

We present a fast learning-based algorithm for deformable, pairwise 3D medical image registration. Current registration methods optimize an objective function independently for each pair of images, which can be time-consuming for large…

Computer Vision and Pattern Recognition · Computer Science 2019-03-14 Guha Balakrishnan , Amy Zhao , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

Conventionally, AI models are thought to trade off explainability for lower accuracy. We develop a training strategy that not only leads to a more explainable AI system for object classification, but as a consequence, suffers no perceptible…

Computer Vision and Pattern Recognition · Computer Science 2020-03-17 Andrea Zunino , Sarah Adel Bargal , Riccardo Volpi , Mehrnoosh Sameki , Jianming Zhang , Stan Sclaroff , Vittorio Murino , Kate Saenko

The challenge of Multimodal Deformable Image Registration (MDIR) lies in the conversion and alignment of features between images of different modalities. Generative models (GMs) cannot retain the necessary information enough from the source…

Computer Vision and Pattern Recognition · Computer Science 2024-08-21 Mingrui Ma , Weijie Wang , Jie Ning , Jianfeng He , Nicu Sebe , Bruno Lepri

Multiple Sclerosis (MS) is a type of brain disease which causes visual, sensory, and motor problems for people with a detrimental effect on the functioning of the nervous system. In order to diagnose MS, multiple screening methods have been…