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Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Development of deep learning systems for biomedical segmentation often requires access to expert-driven, manually annotated datasets. If more than a single expert is involved in the annotation of the same images, then the inter-expert…

Medical image segmentation is vital for modern healthcare and is a key element of computer-aided diagnosis. While recent advancements in computer vision have explored unsupervised segmentation using pre-trained models, these methods have…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Mosong Ma , Tania Stathaki , Michalis Lazarou

Weakly-supervised classification of histopathology slides is a computationally intensive task, with a typical whole slide image (WSI) containing billions of pixels to process. We propose Discriminative Region Active Sampling for Multiple…

Image and Video Processing · Electrical Eng. & Systems 2023-02-23 Jack Breen , Katie Allen , Kieran Zucker , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

Instance segmentation is a form of image detection which has a range of applications, such as object refinement, medical image analysis, and image/video editing, all of which demand a high degree of accuracy. However, this precision is…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Muhammed Korkmaz , T. Metin Sezgin

Existing Earth Vision datasets are either suitable for semantic segmentation or object detection. In this work, we introduce the first benchmark dataset for instance segmentation in aerial imagery that combines instance-level object…

Computer Vision and Pattern Recognition · Computer Science 2019-08-29 Syed Waqas Zamir , Aditya Arora , Akshita Gupta , Salman Khan , Guolei Sun , Fahad Shahbaz Khan , Fan Zhu , Ling Shao , Gui-Song Xia , Xiang Bai

The automatic registration of noninvasive second-harmonic generation microscopy to hematoxylin and eosin slides is a highly desired, yet still unsolved problem. The task is challenging because the second-harmonic images contain only partial…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Marek Wodzinski , Henning Müller

Manually annotating object segmentation masks is very time consuming. Interactive object segmentation methods offer a more efficient alternative where a human annotator and a machine segmentation model collaborate. In this paper we make…

Computer Vision and Pattern Recognition · Computer Science 2019-04-18 Rodrigo Benenson , Stefan Popov , Vittorio Ferrari

Hematoxylin and Eosin (H&E) staining is a cornerstone of pathological analysis, offering reliable visualization of cellular morphology and tissue architecture for cancer diagnosis, subtyping, and grading. Immunohistochemistry (IHC) staining…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Amit Das , Naofumi Tomita , Kyle J. Syme , Weijie Ma , Paige O'Connor , Kristin N. Corbett , Bing Ren , Xiaoying Liu , Saeed Hassanpour

Separating and labeling each instance of a nucleus (instance-aware segmentation) is the key challenge in segmenting single cell nuclei on fluorescence microscopy images. Deep Neural Networks can learn the implicit transformation of a…

Computer Vision and Pattern Recognition · Computer Science 2021-08-11 Florian Kromp , Lukas Fischer , Eva Bozsaky , Inge Ambros , Wolfgang Doerr , Sabine Taschner-Mandl , Peter Ambros , Allan Hanbury

In the effort to aid cytologic diagnostics by establishing automatic single cell screening using high throughput digital holographic microscopy for clinical studies thousands of images and millions of cells are captured. The bottleneck lies…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Julia Sistermanns , Ellen Emken , Gregor Weirich , Oliver Hayden , Wolfgang Utschick

In surgical procedures, correct instrument counting is essential. Instance segmentation is a location method that locates not only an object's bounding box but also each pixel's specific details. However, obtaining mask-level annotations is…

Computer Vision and Pattern Recognition · Computer Science 2023-11-17 Zhen Sun , Huan Xu , Jinlin Wu , Zhen Chen , Zhen Lei , Hongbin Liu

Computational pathology methods have the potential to improve access to precision medicine, as well as the reproducibility and accuracy of pathological diagnoses. Particularly the analysis of whole-slide-images (WSIs) of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Philippe Weitz , Viktoria Sartor , Balazs Acs , Stephanie Robertson , Daniel Budelmann , Johan Hartman , Mattias Rantalainen

Hematoxylin and Eosin (H&E) has been the gold standard in tissue analysis for decades, however, tissue specimens stained in different laboratories vary, often significantly, in appearance. This variation poses a challenge for both…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Umair Khan , Jouni Härkönen , Marjukka Friman , Leena Latonen , Teijo Kuopio , Pekka Ruusuvuori

Segmentation of anatomical structures and pathologies is inherently ambiguous. For instance, structure borders may not be clearly visible or different experts may have different styles of annotating. The majority of current state-of-the-art…

H-score is a semi-quantitative method used to assess the presence and distribution of proteins in tissue samples by combining the intensity of staining and percentage of stained nuclei. It is widely used but time-consuming and can be…

Background: Cell segmentation in bright-field histological slides is a crucial topic in medical image analysis. Having access to accurate segmentation allows researchers to examine the relationship between cellular morphology and clinical…

Accurate segmentation of tissue in histopathological images can be very beneficial for defining regions of interest (ROI) for streamline of diagnostic and prognostic tasks. Still, adapting to different domains is essential for…

Image and Video Processing · Electrical Eng. & Systems 2023-03-10 Saul Fuster , Farbod Khoraminia , Trygve Eftestøl , Tahlita C. M. Zuiverloon , Kjersti Engan

Tissue segmentation is a routine preprocessing step to reduce the computational cost of whole slide image (WSI) analysis by excluding background regions. Traditional image processing techniques are commonly used for tissue segmentation, but…

Image and Video Processing · Electrical Eng. & Systems 2024-01-25 Ruben T. Lucassen , Willeke A. M. Blokx , Mitko Veta

Automated chromosome instance segmentation from metaphase cell microscopic images is critical for the diagnosis of chromosomal disorders (i.e., karyotype analysis). However, it is still a challenging task due to lacking of densely annotated…

Computer Vision and Pattern Recognition · Computer Science 2023-04-26 Dan You , Pengcheng Xia , Qiuzhu Chen , Minghui Wu , Suncheng Xiang , Jun Wang