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Efficient particle sorting in microfluidic systems is vital for advancements in biomedical diagnostics and industrial applications. This study numerically investigates particle migration and passive sorting in symmetric serpentine…

Fluid Dynamics · Physics 2025-09-16 Sayan Karmakar , Anish Pal , Sourav Sarkar , Achintya Mukhopadhyay

Inertial microfluidics is a promising tool for many lab-on-a-chip applications. Particles in channel flows with Reynolds numbers above one undergo cross-streamline migration to a discrete set of equilibrium positions in square and…

Fluid Dynamics · Physics 2014-02-04 Christopher Prohm , Holger Stark

The problem of an accurate Eulerian-Lagrangian modeling of inertial particle dispersion in Large Eddy Simulation (LES) of turbulent wall-bounded flows is addressed. We run Direct Numerical Simulation (DNS) for turbulent channel flow at…

Fluid Dynamics · Physics 2009-11-13 C. Marchioli , M. V. Salvetti , A. Soldati

Inertial fluid flow deformation around pillars in a microchannel is a new method for controlling fluid flow. Sequences of pillars have been shown to produce a rich phase space with a wide variety of flow transformations. Previous work has…

Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer…

Fluid Dynamics · Physics 2024-06-03 Zunmin Zhang , Wei Chien , Ewan Henry , Dmitry A. Fedosov , Gerhard Gompper

Viscoelastic microfluidic devices are promising for various microscale procedures such as particle sorting and separation. In this study, we perform three dimensional computational investigation of a particle in a viscoelastic channel flow…

Fluid Dynamics · Physics 2019-10-29 Amir Hossein Raffiee , Arezoo M. Ardekani , Sadegh Dabiri

Motivated by recent experimental advances (Stroock et al. 2002) in microfluidic mixers, we study the passive mixing and flow properties of a patterned microchannel by means of computational fluid dynamics (CFD). Such geometries overcome the…

Soft Condensed Matter · Physics 2007-05-23 J. P. Bennett , C. H. Wiggins

The size- and fluorescence-based sorting of micro- and nano-scale particles suspended in fluid presents a significant and important challenge for both sample analysis and for manufacturing of nanoparticle-based products. Here we demonstrate…

Soft Condensed Matter · Physics 2015-02-16 Sukumar Rajauria , Christopher Axline , Claudia Gottstein , Andrew N. Cleland

Sorting cells based on their mechanical properties is essential for applications in disease diagnostics, cell therapy, and biomedical research. Deterministic Lateral Displacement (DLD) devices provide a label-free method for achieving such…

Quantitative Methods · Quantitative Biology 2025-12-08 Khayrul Islam , Mehedi Hasan , Yaling Liu

We propose a defiltering method of turbulent flow fields for Lagrangian particle tracking using machine learning techniques. Numerical simulation of Lagrangian particle tracking is commonly used in various fields. In general, practical…

Fluid Dynamics · Physics 2024-11-21 Tomoya Oura , Koji Fukagata

Microfluidic technologies are commonly used for the manipulation of red blood cell (RBC) suspensions and analyses of flow-mediated biomechanics. To enhance the performance of microfluidic devices, understanding the dynamics of the…

Deterministic lateral displacement (DLD) microfluidic devices promise versatile and precise processing of biological samples. However, this prospect has been realized so far only for rigid spherical particles and remains limited for…

Soft Condensed Matter · Physics 2024-06-03 Wei Chien , Zunmin Zhang , Gerhard Gompper , Dmitry A. Fedosov

Hydrogen fuel cells are a key technology in the transition toward carbon-neutral energy systems, offering clean power with water as the only byproduct. Microfluidic fuel cells, which operate at the microliter scale, are an emerging variant…

Computational Engineering, Finance, and Science · Computer Science 2026-03-31 Michel Takken , Robert Wille

Fluidic injection provides a promising solution to improve the performance of overexpanded single expansion ramp nozzle (SERN) during vehicle acceleration. However, determining the injection parameters for the best overall performance under…

Fluid Dynamics · Physics 2024-09-20 Yunjia Yang , Jiazhe Li , Yufei Zhang , Haixin Chen

We investigate the transport dynamics of elongated microparticles in microchannel flows. While smooth-walled channels preserve the dependence of particle trajectories on initial orientation and lateral position, we show that introducing…

Fluid Dynamics · Physics 2026-04-13 Fatemeh S. Ahmadi , Hossein Hamzehpour , Reza Shaebani

The effects of cell size and deformability on the lateral migration and deformation of living cells flowing through a rectangular microchannel has been numerically investigated and compared with the inertial-microfluidics data on detection…

Fluid Dynamics · Physics 2013-06-21 Hongzhi Lan , Soojung Claire Hur , Dino Di Carlo , Damir B. Khismatullin

Particles traveling through inertial microfluidic devices migrate to focusing streamlines. We present a numerical method that calculates migration velocities of particles in inertial microfluidic channels of arbitrary cross section by…

Fluid Dynamics · Physics 2022-10-19 Samuel Christensen , Raymond Chu , Christopher R Anderson , Marcus Roper

Deep learning has achieved spectacular performance in image and speech recognition and synthesis. It outperforms other machine learning algorithms in problems where large amounts of data are available. In the area of measurement technology,…

Quantitative Methods · Quantitative Biology 2019-08-20 Yueqin Li , Ata Mahjoubfar , Claire Lifan Chen , Kayvan Reza Niazi , Li Pei , Bahram Jalali

In this work, we aim to deepen the understanding of inertial clustering and the role of sling events in high-Reynolds number ($Re$) particle-laden turbulence. To this end, we perform one-way coupled particle tracking in flow fields obtained…

Fluid Dynamics · Physics 2025-01-09 Lukas A. Codispoti , Daniel W. Meyer , Patrick Jenny

We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating…

Soft Condensed Matter · Physics 2015-10-27 Rohan Vernekar , Timm Krüger
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