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This paper aims to provide a comprehensive critical overview on how entities and their interactions in Complex Networked Systems (CNS) are modelled across disciplines as they approach their ultimate goal of creating a Digital Twin (DT) that…

Systems and Control · Electrical Eng. & Systems 2022-02-22 Jiaqi Wen , Bogdan Gabrys , Katarzyna Musial

Diffusion Tensor Imaging (DTI) is an effective tool for the analysis of structural brain connectivity in normal development and in a broad range of brain disorders. However efforts to derive inherent characteristics of structural brain…

Computational Engineering, Finance, and Science · Computer Science 2018-02-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

The aim of this paper is to give an overview of brain organoid computing, its characteristics, challenges, as well as possible advantages for future applications in the field of artificial intelligence. An important part is the extensive…

Emerging Technologies · Computer Science 2025-11-04 Yannic Talavera , Bernd Ulmann

Cardiac digital twins are computational tools capturing key functional and anatomical characteristics of patient hearts for investigating disease phenotypes and predicting responses to therapy. When paired with large-scale computational…

Computational Engineering, Finance, and Science · Computer Science 2024-01-19 Julia Camps , Zhinuo Jenny Wang , Ruben Doste , Maxx Holmes , Brodie Lawson , Jakub Tomek , Kevin Burrage , Alfonso Bueno-Orovio , Blanca Rodriguez

Cyber defense is reactive and slow. On average, the time-to-remedy is hundreds of times larger than the time-to-compromise. In response to the expanding ever-more-complex threat landscape, Digital Twins (DTs) and particularly Human Digital…

Artificial Intelligence · Computer Science 2022-04-22 Tam N. Nguyen

Optical communication is developing rapidly in the directions of hardware resource diversification, transmission system flexibility, and network function virtualization. Its proliferation poses a significant challenge to traditional optical…

Networking and Internet Architecture · Computer Science 2020-11-11 Danshi Wang , Zhiguo Zhang , Min Zhang , Meixia Fu , Jin Li , Shanyong Cai , Chunyu Zhang , Xue Chen

The goal of the Human Brain Project is to develop during the next decade an infrastructure necessary for running a simulation of the entire human brain constrained by current experimental data. One of the key issues is therefore to…

Quantitative Methods · Quantitative Biology 2017-06-23 Paul Tiesinga , Rembrandt Bakker , Sean Hill , Jan G. Bjaalie

The collaboration between humans and robots re-quires a paradigm shift not only in robot perception, reasoning, and action, but also in the design of the robotic cell. This paper proposes an optimization framework for designing…

Robotics · Computer Science 2024-10-21 Christian Cella , Marco Faroni , Andrea Zanchettin , Paolo Rocco

The increasing capabilities of Digital Twins (DTs) in the context of the Internet of Things (IoT) and Industrial IoT (IIoT) call for seamless integration with simulation platforms to support system design, validation, and real-time…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-02 Marco Picone , Samuele Burattini , Marco Melloni , Prasad Talasila , Davide Ziglioli , Matteo Martinelli , Nicola Bicocchi , Alessandro Ricci , Peter Gorm Larsen

In this work, we introduce a novel computational framework that we developed to use numerical simulations to investigate the complexity of brain tissue at a microscopic level with a detail never realised before. Directly inspired by the…

Medical Physics · Physics 2018-06-20 Marco Palombo , Daniel C. Alexander , Hui Zhang

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Insufficient data volume and quality are particularly pressing challenges in the adoption of modern subsymbolic AI. To alleviate these challenges, AI simulation uses virtual training environments in which AI agents can be safely and…

Artificial Intelligence · Computer Science 2025-09-01 Xiaoran Liu , Istvan David

The brains of all bilaterally symmetric animals on Earth are divided into left and right hemispheres. The anatomy and functionality of the hemispheres have a large degree of overlap, but there are asymmetries, and they specialise in…

Neurons and Cognition · Quantitative Biology 2024-07-11 Chandramouli Rajagopalan , David Rawlinson , Elkhonon Goldberg , Gideon Kowadlo

With the rapid development of deep learning, Deep Spiking Neural Networks (DSNNs) have emerged as promising due to their unique spike event processing and asynchronous computation. When deployed on neuromorphic chips, DSNNs offer…

Neural and Evolutionary Computing · Computer Science 2024-07-15 Hui Xie , Ge Yang , Wenjuan Gao

A Digital Twin is a virtual system that can fully describe a physical one. It constantly receives data from its counterpart's sensors, consults external sources, and obtains manual inputs from its stakeholders. The DT uses all this…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-01-02 Laura Bragante Corssac , Juliano Araujo Wickboldt

The simulation of whole-brain dynamics should reproduce realistic spontaneous and evoked neural activity across different scales, including emergent rhythms, spatio-temporal activation patterns, and macroscale complexity. Once a…

Digital twin has recently attracted growing attention, leading to intensive research and applications. Along with this, a new research area, dubbed as "human digital twin" (HDT), has emerged. Similar to the conception of digital twin, HDT…

Human-Computer Interaction · Computer Science 2022-12-13 Yujia Lin , Liming Chen , Aftab Ali , Christopher Nugent , Cleland Ian , Rongyang Li , Dazhi Gao , Hang Wang , Yajie Wang , Huansheng Ning

We present an LLM-powered social discovery platform that uses digital twins to autonomously evaluate interpersonal compatibility through behavioral simulation. The platform unifies three key pillars: (1) digital twins that engage in…

Datacenters are the backbone of our digital society, but raise numerous operational challenges. We envision digital twins becoming primary instruments in datacenter operations, continuously and autonomously helping with major operational…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-14 Radu Nicolae , Jules van der Toorn , Stavriana Kraniti , Houcen Liu , Alexandru Iosup

Biological brains demonstrate complex neural activity, where neural dynamics are critical to how brains process information. Most artificial neural networks ignore the complexity of individual neurons. We challenge that paradigm. By…

Machine Learning · Computer Science 2025-10-06 Luke Darlow , Ciaran Regan , Sebastian Risi , Jeffrey Seely , Llion Jones