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Here, we present the Digital Brain (DB), a platform for simulating spiking neuronal networks at the large neuron scale of the human brain based on personalized magnetic-resonance-imaging data and biological constraints. The DB aims to…

Neurons and Cognition · Quantitative Biology 2024-10-25 Wenlian Lu , Xin Du , Jiexiang Wang , Longbin Zeng , Leijun Ye , Shitong Xiang , Qibao Zheng , Jie Zhang , Ningsheng Xu , Jianfeng Feng

In recent years, advances in neuroscience and artificial intelligence have paved the way for unprecedented opportunities for understanding the complexity of the brain and its emulation by computational systems. Cutting-edge advancements in…

Neurons and Cognition · Quantitative Biology 2024-04-19 Hui Xiong , Congying Chu , Lingzhong Fan , Ming Song , Jiaqi Zhang , Yawei Ma , Ruonan Zheng , Junyang Zhang , Zhengyi Yang , Tianzi Jiang

The Digital Twin Brain (DTB) is an advanced artificial intelligence framework that integrates spiking neurons to simulate complex cognitive functions and collaborative behaviors. For domain experts, visualizing the DTB's simulation outcomes…

Human-Computer Interaction · Computer Science 2025-05-30 Jun-Hsiang Yao , Mingzheng Li , Jiayi Liu , Yuxiao Li , Jielin Feng , Jun Han , Qibao Zheng , Jianfeng Feng , Siming Chen

The integration of immersive communication into a human-centric ecosystem has intensified the demand for sophisticated Human Digital Twins (HDTs) driven by multifaceted human data. However, the effective construction of HDTs faces…

Human-Computer Interaction · Computer Science 2026-05-21 Chen Shang , Jiadong Yu , Dinh Thai Hoang

Current methodologies typically integrate biophysical brain models with functional magnetic resonance imaging(fMRI) data - while offering millimeter-scale spatial resolution (0.5-2 mm^3 voxels), these approaches suffer from limited temporal…

Neurons and Cognition · Quantitative Biology 2025-07-17 Yubo Hou , Zhengxin Zhang , Ziyi Wang , Wenlian Lu , Jianfeng Feng , Taiping Zeng

Digital twin technology is an essential approach to managing the lifecycle of industrial products. Among the many approaches used to manage digital twins, co-simulation has proven to be a reliable one. There have been multiple attempts to…

A human body digital twin (DT) is a virtual representation of an individual's physiological state, created using real-time data from sensors and medical test devices, with the purpose of simulating, predicting, and optimizing health…

Artificial Intelligence · Computer Science 2024-04-24 Chenyu Tang , Wentian Yi , Edoardo Occhipinti , Yanning Dai , Shuo Gao , Luigi G. Occhipinti

Spiking neural networks (SNNs) are gaining popularity in the computational simulation and artificial intelligence fields owing to their biological plausibility and computational efficiency. This paper explores the historical development of…

Neural and Evolutionary Computing · Computer Science 2024-08-29 Tianyu Zheng , Liyuan Han , Tielin Zhang

Brain digital twins aim to provide faithful, individualized computational representations of brains as dynamical systems, enabling mechanistic understanding and supporting prediction of clinical interventions. Yet current approaches remain…

Computational Engineering, Finance, and Science · Computer Science 2026-04-16 Alexandre Muzy

As deep learning models scale, they become increasingly competitive from domains spanning from computer vision to natural language processing; however, this happens at the expense of efficiency since they require increasingly more memory…

Neural and Evolutionary Computing · Computer Science 2024-01-30 Fabrizio Ottati , Chang Gao , Qinyu Chen , Giovanni Brignone , Mario R. Casu , Jason K. Eshraghian , Luciano Lavagno

Current neural interfaces such as brain-computer interfaces (BCIs) face several fundamental challenges, including frequent recalibration due to neuroplasticity and session-to-session variability, real-time processing latency, limited…

Human-Computer Interaction · Computer Science 2026-01-06 Mohammad Mahdi Habibi Bina , Sepideh Baghernezhad , Mohammad Reza Daliri , Mohammad Hassan Moradi

A patient's digital twin is a computational model that describes the evolution of their health over time. Digital twins have the potential to revolutionize medicine by enabling individual-level computer simulations of human health, which…

Human Digital Twins (HDTs) are digital replicas of humans that either mirror a complete human body, some parts of it as can be organs, flows, cells, or even human behaviors. An HDT is a human specific replica application inferred from the…

Other Computer Science · Computer Science 2023-02-08 Heribert Pascual , Xavi Masip Bruin , Albert Alonso , Judit Cerdà

Hierarchical Temporal Memory (HTM) is a computational theory of machine intelligence based on a detailed study of the neocortex. The Heidelberg Neuromorphic Computing Platform, developed as part of the Human Brain Project (HBP), is a…

Neurons and Cognition · Quantitative Biology 2016-02-10 Sebastian Billaudelle , Subutai Ahmad

Spiking neural networks excel at event-driven sensing. Yet, maintaining task-relevant context over long timescales both algorithmically and in hardware, while respecting both tight energy and memory budgets, remains a core challenge in the…

Neural and Evolutionary Computing · Computer Science 2026-05-05 Pengfei Sun , Zhe Su , Jascha Achterberg , Giacomo Indiveri , Dan F. M. Goodman , Danyal Akarca

The emergence of beyond 5G (B5G) and 6G networks underscores the critical role of advanced computer-aided tools, such as network digital twins (DTs), in fostering autonomous networks and ubiquitous intelligence. Existing solutions in the DT…

Networking and Internet Architecture · Computer Science 2024-09-04 Caglar Tunc , Kubra Duran , Buse Bilgin , Gokhan Kalem , Berk Canberk

The human brain has immense learning capabilities at extreme energy efficiencies and scale that no artificial system has been able to match. For decades, reverse engineering the brain has been one of the top priorities of science and…

We present a multi-scale differentiable brain modeling workflow utilizing BrainPy, a unique differentiable brain simulator that combines accurate brain simulation with powerful gradient-based optimization. We leverage this capability of…

Neural and Evolutionary Computing · Computer Science 2024-09-26 Chaoming Wang , Muyang Lyu , Tianqiu Zhang , Sichao He , Si Wu

In this paper, we introduce a decentralized digital twin (DDT) framework for dynamical systems and discuss the prospects of the DDT modeling paradigm in computational science and engineering applications. The DDT approach is built on a…

Machine Learning · Computer Science 2022-07-26 Omer San , Suraj Pawar , Adil Rasheed

Digital twin (DT), refers to a promising technique to digitally and accurately represent actual physical entities. One typical advantage of DT is that it can be used to not only virtually replicate a system's detailed operations but also…

Networking and Internet Architecture · Computer Science 2023-09-08 Jiayuan Chen , Changyan Yi , Samuel D. Okegbile , Jun Cai , Xuemin , Shen
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