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From scientific experiments to online A/B testing, the previously observed data often affects how future experiments are performed, which in turn affects which data will be collected. Such adaptivity introduces complex correlations between…
This thesis responds to the challenges of using a large number, such as thousands, of features in regression and classification problems. There are two situations where such high dimensional features arise. One is when high dimensional…
The mutual information between two jointly distributed random variables $X$ and $Y$ is a functional of the joint distribution $P_{XY},$ which is sometimes difficult to handle or estimate. A coarser description of the statistical behavior of…
A model that predicts the outcome of collisions between droplets and particles in terms of the distribution of the droplet volume post-collision is lacking, in contrast to the case for droplet-droplet interactions. Taking existing models…
Quantile regression is a powerful tool for detecting exposure-outcome associations given covariates across different parts of the outcome's distribution, but has two major limitations when the aim is to infer the effect of an exposure.…
The nucleus-nucleus impact parameter and collision geometry of a heavy ion collision are typically characterized by assigning a collision "centrality". In all present heavy ion experiments centrality is measured indirectly, by detecting the…
Under certain conditions, the dynamics of a nonlinear mechanical system can be represented by a single nonlinear modal oscillator. The properties of the modal oscillator can be determined by computational or experimental nonlinear modal…
Understanding the dependence structure between response variables is an important component in the analysis of correlated multivariate data. This article focuses on modeling dependence structures in multivariate binary data, motivated by a…
Nonlinear longitudinal proportional effect models have been proposed to improve power and provide direct estimates of the proportional treatment effect in randomized clinical trials. These models assume a fixed proportional treatment effect…
To date, testing interactions in high dimensions has been a challenging task. Existing methods often have issues with sensitivity to modeling assumptions and heavily asymptotic nominal p-values. To help alleviate these issues, we propose a…
In ultrarelativistic heavy-ion experiments, one estimates the centrality of a collision by using a single observable, say $n$, typically given by the transverse energy or the number of tracks observed in a dedicated detector. The…
Residuals in regression models are often spatially correlated. Prominent examples include studies in environmental epidemiology to understand the chronic health effects of pollutants. I consider the effects of residual spatial structure on…
In observational studies, researchers must select a method to control for confounding. Options include propensity score methods and regression. It remains unclear how dataset characteristics (size, overlap in propensity scores, exposure…
This article is motivated by the problem of inference on interactions among chemical exposures impacting human health outcomes. Chemicals often co-occur in the environment or in synthetic mixtures and as a result exposure levels can be…
An individual has been subjected to some exposure and has developed some outcome. Using data on similar individuals, we wish to evaluate, for this case, the probability that the outcome was in fact caused by the exposure. Even with the best…
We examine the leading order noncommutative corrections to the differential and total cross sections for e+ e- --> q q-bar. After averaging over the earth's rotation, the results depend on the latitude for the collider, as well as the…
A random interaction matrix model is used to study the statistics of conductance peak heights in Coulomb blockade quantum dots. When the single-particle dynamics conserves time-reversal symmetry, the peak height statistics is insensitive to…
Consider a multinomial regression model where the response, which indicates a unit's membership in one of several possible unordered classes, is associated with a set of predictor variables. Such models typically involve a matrix of…
Due to concerns about parametric model misspecification, there is interest in using machine learning to adjust for confounding when evaluating the causal effect of an exposure on an outcome. Unfortunately, exposure effect estimators that…
Consider two sets of entities and their members' mutual affinity values, say drug-target affinities (DTA). Drugs and targets are said to interact in their effects on DTAs if drug's effect on it depends on the target. Presence of interaction…