Related papers: Structure Preserving Polytopal Discontinuous Galer…
This work focuses on the conservation of quantities such as Hamiltonians, mass, and momentum when solution fields of partial differential equations are approximated with nonlinear parametrizations such as deep networks. The proposed…
For hyperbolic conservation laws, traditional methods and physics-informed neural networks (PINNs) often encounter difficulties in capturing sharp discontinuities and maintaining temporal consistency. To address these challenges, we…
Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an…
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the progressive accumulation of misfolded proteins, leading to cognitive decline. This study presents a novel stochastic modelling approach to simulate the…
We propose a mathematical model for the onset and progression of Alzheimer's disease based on transport and diffusion equations. We treat brain neurons as a continuous medium and structure them by their degree of malfunctioning. Three…
We develop and analyze a class of structure-preserving discontinuous Galerkin schemes for the nonlinear Vlasov-Poisson-Fokker-Planck model, reformulated as a hyperbolic system through a Hermite expansion in the velocity variable. We…
We address the spatial discretization of an evolution problem arising from the coupling of viscoelastic and acoustic wave propagation phenomena by employing a discontinuous Galerkin scheme on polygonal and polyhedral meshes. The coupled…
In this work, we develop model for neuronal degeneration based on polymer chain folding dynamics and their connectivity in various scale. In the first phase, we just developed the model and numerical simulation need to be complete in order…
A key property of the linear Boltzmann semiconductor model is that as the collision frequency tends to infinity, the phase space density $f = f(x,v,t)$ converges to an isotropic function $M(v)\rho(x,t)$, called the drift-diffusion limit,…
In this paper, we design and analyze third order positivity-preserving discontinuous Galerkin (DG) schemes for solving the time-dependent system of Poisson--Nernst--Planck (PNP) equations, which has found much use in diverse applications.…
This work is concerned with the analysis of a space-time finite element discontinuous Galerkin method on polytopal meshes (XT-PolydG) for the numerical discretization of wave propagation in coupled poroelastic-elastic media. The…
Multiscale mathematical models have shown great promise in computational brain electrophysiology but are still hindered by high computational costs due to fast dynamics and complex brain geometries, requiring very fine spatio-temporal…
In this work we review discontinuous Galerkin finite element methods on polytopal grids (PolydG) for the numerical simulation of multiphysics wave propagation phenomena in heterogeneous media. In particular, we address wave phenomena in…
Accumulation of amyloid beta proteins is a defining feature of Alzheimer's disease, and is usually accompanied by cerebrovascular pathology. Evidence suggests that amyloid beta and cerebrovascular pathology are mutually reinforcing; in…
Neurodegenerative diseases are closely associated with the amplification and invasion of toxic proteins. In particular Alzheimer's disease is characterized by the systematic progression of amyloid-$\beta$ and $\tau$-proteins in the brain.…
A structure preserving proper orthogonal decomposition reduce-order modeling approach has been developed in [Gong et al. 2017] for the Hamiltonian system, which uses the traditional framework of Galerkin projection-based model reduction but…
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, yet there is no disease-modifying therapy up to this date. The biological complexity underlying PD hampers the investigation of the principal…
This paper is concerned with structure-preserving numerical approximations for a class of nonlinear nonlocal Fokker-Planck equations, which admit a gradient flow structure and find application in diverse contexts. The solutions,…
We extend the positivity-preserving method of Zhang & Shu (2010, JCP, 229, 3091-3120) to simulate the advection of neutral particles in phase space using curvilinear coordinates. The ability to utilize these coordinates is important for…
In this paper, we develop an asymptotic-preserving and positivity-preserving discontinuous Galerkin (DG) method for solving the semiconductor Boltzmann equation in the diffusive scaling. We first formulate the diffusive relaxation system…