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Multi-Arm, Multi-Stage (MAMS) clinical trial designs allow for multiple therapies to be compared across a spectrum of clinical trial phases. MAMS designs can be categorized into several overarching design groups, including adaptive designs…

Multilevel methods are among the most efficient numerical methods for solving large-scale systems of equations that arise from discretized partial differential equations. Two-level convergence theory plays a fundamental role in the analysis…

Numerical Analysis · Mathematics 2025-06-04 Xuefeng Xu

In this work we study binary two-stage robust optimization problems with objective uncertainty. We present an algorithm to calculate efficiently lower bounds for the binary two-stage robust problem by solving alternately the underlying…

Optimization and Control · Mathematics 2020-01-17 Nicolas Kämmerling , Jannis Kurtz

We consider algorithmic approaches to the D-optimality problem for cases where the input design matrix is large and highly structured, in particular implicitly specified as a full quadratic or linear response-surface model in several levels…

Optimization and Control · Mathematics 2023-09-11 Gabriel Ponte , Marcia Fampa , Jon Lee

Data collection costs can vary widely across variables in data science tasks. Two-phase designs can be employed to save data collection costs. This paper considers the two-phase studies where inexpensive variables are collected for all…

Methodology · Statistics 2025-12-04 Ruoyu Wang , Qihua Wang , Wang Miao

In this work we present the results of several simulations on main-effect factorial designs. The goal of such simulations is to investigate the connections between the $D$-optimality of a design and its geometrical structure. By means of a…

Computation · Statistics 2016-04-18 Roberto Fontana , Fabio Rapallo

Cumulative link models have been widely used for ordered categorical responses. Uniform allocation of experimental units is commonly used in practice, but often suffers from a lack of efficiency. We consider D-optimal designs with ordered…

Statistics Theory · Mathematics 2017-11-09 Jie Yang , Liping Tong , Abhyuday Mandal

Modeling human operator's dynamic plays a very important role in the manual closed-loop control system, and it is an active research area for several decades. Based on the characteristics of human brain and behaviour, a new kind of…

Systems and Control · Computer Science 2016-01-11 Jiacai Huang , Yangquan Chen , Haibin Li , Xinxin Shi

Given a formal context, an ordinal factor is a subset of its incidence relation that forms a chain in the concept lattice, i.e., a part of the dataset that corresponds to a linear order. To visualize the data in a formal context, Ganter and…

Artificial Intelligence · Computer Science 2023-06-21 Dominik Dürrschnabel , Gerd Stumme

In this paper, we investigate the row-factorization matrices of Arf numerical semigroups, and we provide the full list of such matrices of certain Arf numerical semigroups. We use the information of row-factorization matrices to detect the…

Commutative Algebra · Mathematics 2025-04-11 Meral Süer , Mehmet Yeşil

In this paper, we discuss distributed optimization over directed graphs, where doubly-stochastic weights cannot be constructed. Most of the existing algorithms overcome this issue by applying push-sum consensus, which utilizes…

Optimization and Control · Mathematics 2019-01-30 Ran Xin , Chenguang Xi , Usman A. Khan

Given two 2-level factors of interest, a 2^2 split-plot design} (a) takes each of the $2^2=4$ possible factorial combinations as a treatment, (b) identifies one factor as `whole-plot,' (c) divides the experimental units into blocks, and (d)…

Methodology · Statistics 2016-02-15 Anqi Zhao , Peng Ding , Tirthankar Dasgupta

We propose novel optimal designs for longitudinal data for the common situation where the resources for longitudinal data collection are limited, by determining the optimal locations in time where measurements should be taken. As for all…

Methodology · Statistics 2016-04-20 Hao Ji , Hans-Georg Müller

For run sizes that are a multiple of four, the literature offers many two-level designs that are D- and A-optimal for the main-effects model and minimize the aliasing between main effects and interaction effects and among interaction…

Methodology · Statistics 2025-12-25 Mohammed Saif Ismail Hameed , Jose Núñez Ares , Eric D. Schoen , Peter Goos

This paper presents an algorithm to automatically design two-level fat-tree networks, such as ones widely used in large-scale data centres and cluster supercomputers. The two levels may each use a different type of switches from design…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-01-29 Konstantin S. Solnushkin

Factorial designs are widely used in agriculture, engineering, and the social sciences to study the causal effects of several factors simultaneously on a response. The objective of such a design is to estimate all factorial effects of…

Methodology · Statistics 2015-11-09 Zach Branson , Tirthankar Dasgupta , Donald B. Rubin

$2^K$ factorial designs are widely adopted by statisticians and the broader scientific community. In this short note, under the potential outcomes framework (Neyman, 1923; Rubin, 1974), we adopt the partial identification approach and…

Methodology · Statistics 2019-07-18 Jiannan Lu

Two point correlation functions of the off-critical primary fields \phi_{1, 1+s} are considered in the perturbed minimal models M_{2, 2N+3} + \phi_{1,3}. They are given as infinite series of form factor contributions. The form factors of…

High Energy Physics - Theory · Physics 2008-11-26 Takeshi Oota

Purpose: Two-stage single-arm trial designs are commonly used in phase II oncology to infer treatment effects for a binary primary outcome (e.g., tumour response). It is imperative that such studies be designed, analysed, and reported…

Applications · Statistics 2020-07-09 Michael J. Grayling , Adrian P. Mander

Set-point tracking for systems with unknown model parameters is a fundamental problem in control, and two-degree-of-freedom (2DOF) Proportional-Integral (PI) controllers -- consisting of a feedforward controller and PI controller -- are…

Optimization and Control · Mathematics 2026-01-08 Taiga Kiyota , Kazuhiro Sato