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Structure-informed protein representation learning is essential for effective protein function annotation and \textit{de novo} design. However, the presence of inherent noise in both crystal and AlphaFold-predicted structures poses…

Biomolecules · Quantitative Biology 2025-03-25 Zhongyue Zhang , Runze Ma , Yanjie Huang , Shuangjia Zheng

In this paper, a new method to efficiently simulate diffusion controlled second order chemical reactions is derived and applied to site-specific DNA-binding proteins. The protein enters a spherical cell and propagates via two competing…

Biological Physics · Physics 2009-11-11 Holger Merlitz , Konstantin V. Klenin , Chen-Xu Wu , Jörg Langowski

Diffusion models have gradually gained prominence in the field of image synthesis, showcasing remarkable generative capabilities. Nevertheless, the slow inference and complex networks, resulting from redundancy at both temporal and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xuewen Liu , Zhikai Li , Qingyi Gu

Diffusion models have achieved remarkable success in image generation but their practical application is often hindered by the slow sampling speed. Prior efforts of improving efficiency primarily focus on compressing models or reducing the…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Jiuyi Xu , Qing Jin , Meida Chen , Andrew Feng , Yang Sui , Yangming Shi

Previously, non-autoregressive models were widely perceived as being superior in generation efficiency but inferior in generation quality due to the difficulties of modeling multiple target modalities. To enhance the multi-modality modeling…

Computation and Language · Computer Science 2023-11-30 Lihua Qian , Mingxuan Wang , Yang Liu , Hao Zhou

Generative models have attracted considerable attention for speech separation tasks, and among these, diffusion-based methods are being explored. Despite the notable success of diffusion techniques in generation tasks, their adaptation to…

Audio and Speech Processing · Electrical Eng. & Systems 2025-01-28 Jinwei Dong , Xinsheng Wang , Qirong Mao

Denoising diffusion probabilistic models (DDPMs) have pioneered new state-of-the-art results in disciplines such as computer vision and computational biology for diverse tasks ranging from text-guided image generation to structure-guided…

Machine Learning · Computer Science 2024-05-28 Alex Morehead , Jianlin Cheng

The growing adoption of generative AI in real-world applications has exposed a critical bottleneck in the computational demands of diffusion-based text-to-image models. In this work, we propose KDC-Diff, a novel and scalable generative…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Md. Naimur Asif Borno , Md Sakib Hossain Shovon , Asmaa Soliman Al-Moisheer , Mohammad Ali Moni

Error correction codes (ECC) are crucial for ensuring reliable information transmission in communication systems. Choukroun & Wolf (2022b) recently introduced the Error Correction Code Transformer (ECCT), which has demonstrated promising…

Machine Learning · Computer Science 2024-10-10 Matan Levy , Yoni Choukroun , Lior Wolf

Diffusion models are a powerful generative framework, but come with expensive inference. Existing acceleration methods often compromise image quality or fail under complex conditioning when operating in an extremely low-step regime. In this…

Computer Vision and Pattern Recognition · Computer Science 2024-05-09 Jonas Kohler , Albert Pumarola , Edgar Schönfeld , Artsiom Sanakoyeu , Roshan Sumbaly , Peter Vajda , Ali Thabet

Existing diffusion codecs typically build on text-to-image diffusion foundation models like Stable Diffusion. However, text conditioning is suboptimal from a compression perspective, hindering the potential of downstream diffusion codecs,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Zhaoyang Jia , Zihan Zheng , Naifu Xue , Jiahao Li , Bin Li , Zongyu Guo , Xiaoyi Zhang , Houqiang Li , Yan Lu

Diffusion models have become a successful approach for solving various image inverse problems by providing a powerful diffusion prior. Many studies tried to combine the measurement into diffusion by score function replacement, matrix…

Computer Vision and Pattern Recognition · Computer Science 2024-05-20 Hanyu Chen , Zhixiu Hao , Liying Xiao

Text-to-image generation has important implications for generation of diverse and controllable images. Several attempts have been made to adapt Stable Diffusion (SD) to the medical domain. However, the large distribution difference between…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Peng Huang , Xue Gao , Lihong Huang , Jing Jiao , Xiaokang Li , Yuanyuan Wang , Yi Guo

The iterative sampling procedure employed by diffusion models (DMs) often leads to significant inference latency. To address this, we propose Stochastic Consistency Distillation (SCott) to enable accelerated text-to-image generation, where…

Computer Vision and Pattern Recognition · Computer Science 2025-03-06 Hongjian Liu , Qingsong Xie , TianXiang Ye , Zhijie Deng , Chen Chen , Shixiang Tang , Xueyang Fu , Haonan Lu , Zheng-jun Zha

In diffusion and flow-matching generative models, guidance techniques are widely used to improve sample quality and consistency. Classifier-free guidance (CFG) is the de facto choice in modern systems and achieves this by contrasting…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Ankit Yadav , Ta Duc Huy , Lingqiao Liu

In this work, the development and implementation of the effective stochastic potential (ESP) method is presented to perform efficient conformational sampling of molecules. The overarching goal of this work is to alleviate the computational…

Chemical Physics · Physics 2018-08-01 Jeremy A. Scher , Michael G. Bayne , Amogh Srihari , Shikha Nangia , Arindam Chakraborty

Diffusion models are relatively easy to train but require many steps to generate samples. Consistency models are far more difficult to train, but generate samples in a single step. In this paper we propose Multistep Consistency Models: A…

Machine Learning · Computer Science 2024-11-20 Jonathan Heek , Emiel Hoogeboom , Tim Salimans

The recently rising markup-to-image generation poses greater challenges as compared to natural image generation, due to its low tolerance for errors as well as the complex sequence and context correlations between markup and rendered image.…

Computer Vision and Pattern Recognition · Computer Science 2023-08-03 Guojin Zhong , Jin Yuan , Pan Wang , Kailun Yang , Weili Guan , Zhiyong Li

Text-to-image generation via Stable Diffusion models (SDM) have demonstrated remarkable capabilities. However, their computational intensity, particularly in the iterative denoising process, hinders real-time deployment in latency-sensitive…

Computer Vision and Pattern Recognition · Computer Science 2025-05-08 Shuaiting Li , Juncan Deng , Zeyu Wang , Kedong Xu , Rongtao Deng , Hong Gu , Haibin Shen , Kejie Huang

We propose E-MD3C ($\underline{E}$fficient $\underline{M}$asked $\underline{D}$iffusion Transformer with Disentangled $\underline{C}$onditions and $\underline{C}$ompact $\underline{C}$ollector), a highly efficient framework for zero-shot…

Computer Vision and Pattern Recognition · Computer Science 2025-02-14 Trung X. Pham , Zhang Kang , Ji Woo Hong , Xuran Zheng , Chang D. Yoo
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