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Vision-language foundation models have shown great promise in computational pathology but remain primarily data-driven, lacking explicit integration of medical knowledge. We introduce KEEP (KnowledgE-Enhanced Pathology), a foundation model…

Image and Video Processing · Electrical Eng. & Systems 2026-01-28 Xiao Zhou , Luoyi Sun , Dexuan He , Wenbin Guan , Ge Wang , Ruifen Wang , Lifeng Wang , Xiaojun Yuan , Xin Sun , Ya Zhang , Kun Sun , Yanfeng Wang , Weidi Xie

Multi-modal data abounds in biomedicine, such as radiology images and reports. Interpreting this data at scale is essential for improving clinical care and accelerating clinical research. Biomedical text with its complex semantics poses…

Developing computational pathology models is essential for reducing manual tissue typing from whole slide images, transferring knowledge from the source domain to an unlabeled, shifted target domain, and identifying unseen categories. We…

Computer Vision and Pattern Recognition · Computer Science 2024-01-26 Guillaume Vray , Devavrat Tomar , Jean-Philippe Thiran , Behzad Bozorgtabar

In this paper, we design and train a Generative Image-to-text Transformer, GIT, to unify vision-language tasks such as image/video captioning and question answering. While generative models provide a consistent network architecture between…

Computer Vision and Pattern Recognition · Computer Science 2022-12-19 Jianfeng Wang , Zhengyuan Yang , Xiaowei Hu , Linjie Li , Kevin Lin , Zhe Gan , Zicheng Liu , Ce Liu , Lijuan Wang

Recent advancements in foundation models, typically trained with self-supervised learning on large-scale and diverse datasets, have shown great potential in medical image analysis. However, due to the significant spatial heterogeneity of…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Lingxiao Luo , Xuanzhong Chen , Bingda Tang , Xinsheng Chen , Rong Han , Chengpeng Hu , Yujiang Li , Ting Chen

Foundation models have revolutionized the paradigm of digital pathology, as they leverage general-purpose features to emulate real-world pathological practices, enabling the quantitative analysis of critical histological patterns and the…

Medical report generation demands automatic creation of coherent and precise descriptions for medical images. However, the scarcity of labelled medical image-report pairs poses formidable challenges in developing large-scale neural networks…

Computer Vision and Pattern Recognition · Computer Science 2023-12-08 Shibin Wu , Bang Yang , Zhiyu Ye , Haoqian Wang , Hairong Zheng , Tong Zhang

Learning to represent free text is a core task in many clinical machine learning (ML) applications, as clinical text contains observations and plans not otherwise available for inference. State-of-the-art methods use large language models…

Computation and Language · Computer Science 2023-01-30 Lecheng Kong , Christopher King , Bradley Fritz , Yixin Chen

The electrocardiogram (ECG) is the gold standard for non-invasive diagnosis of cardiac pathologies and is a fundamental pillar of cardiovascular medicine. Recent progress in deep learning has led to the development of robust automated…

Controllable pathology image synthesis requires reliable regulation of spatial layout, tissue morphology, and semantic detail. However, existing text-guided diffusion models offer only coarse global control and lack the ability to enforce…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Yuntao Shou , Xiangyong Cao , Qian Zhao , Deyu Meng

Concept-based models naturally lend themselves to the development of inherently interpretable skin lesion diagnosis, as medical experts make decisions based on a set of visual patterns of the lesion. Nevertheless, the development of these…

Computer Vision and Pattern Recognition · Computer Science 2024-03-07 Cristiano Patrício , Luís F. Teixeira , João C. Neves

End-to-end text image translation (TIT), which aims at translating the source language embedded in images to the target language, has attracted intensive attention in recent research. However, data sparsity limits the performance of…

Computation and Language · Computer Science 2022-10-11 Cong Ma , Yaping Zhang , Mei Tu , Xu Han , Linghui Wu , Yang Zhao , Yu Zhou

Text image translation (TIT) aims to translate the source texts embedded in the image to target translations, which has a wide range of applications and thus has important research value. However, current studies on TIT are confronted with…

Computation and Language · Computer Science 2023-06-05 Zhibin Lan , Jiawei Yu , Xiang Li , Wen Zhang , Jian Luan , Bin Wang , Degen Huang , Jinsong Su

Foundation models have recently emerged as powerful feature extractors in computational pathology, yet they typically omit mechanisms for leveraging the global spatial structure of tissues and the local contextual relationships among…

Deep learning relies heavily on data augmentation to mitigate limited data, especially in medical imaging. Recent multimodal learning integrates text and images for segmentation, known as referring or text-guided image segmentation.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Shurong Chai , Rahul Kumar JAIN , Rui Xu , Shaocong Mo , Ruibo Hou , Shiyu Teng , Jiaqing Liu , Lanfen Lin , Yen-Wei Chen

The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods. In this paper, we propose MDNet to establish a direct multimodal…

Computer Vision and Pattern Recognition · Computer Science 2017-07-11 Zizhao Zhang , Yuanpu Xie , Fuyong Xing , Mason McGough , Lin Yang

In Recent Years, Digital Technologies Have Made Significant Strides In Augmenting-Human-Health, Cognition, And Perception, Particularly Within The Field Of Computational-Pathology. This Paper Presents A Novel Approach To Enhancing The…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Xiaoqian Hu

The development of clinical-grade artificial intelligence in pathology is limited by the scarcity of diverse, high-quality annotated datasets. Generative models offer a potential solution but suffer from semantic instability and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Xianchao Guan , Zhiyuan Fan , Yifeng Wang , Fuqiang Chen , Yanjiang Zhou , Zengyang Che , Hongxue Meng , Xin Li , Yaowei Wang , Hongpeng Wang , Min Zhang , Heng Tao Shen , Zheng Zhang , Yongbing Zhang

Clinical text classification is an important problem in medical natural language processing. Existing studies have conventionally focused on rules or knowledge sources-based feature engineering, but only a few have exploited effective…

Computation and Language · Computer Science 2018-07-23 Liang Yao , Chengsheng Mao , Yuan Luo

Large amounts of digitized histopathological data display a promising future for developing pathological foundation models via self-supervised learning methods. Foundation models pretrained with these methods serve as a good basis for…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Shengyi Hua , Fang Yan , Tianle Shen , Lei Ma , Xiaofan Zhang