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Correct measurement of the shell properties of coated microbubbles (MBs) is essential to understanding and optimizing their response to ultrasound (US) exposure parameters in diagnostic and therapeutic ultrasound. MBs are surrounded by…

A lipid coated bubble (LCB) oscillator is a very interesting non-smooth oscillator with many important applications ranging from industry and chemistry to medicine. However, due to the complex behavior of the coating intermixed with the…

Fluid Dynamics · Physics 2021-07-28 AJ Sojahrood , H. Haghi , T. M. Porter , R. Karshafian , M. C. Kolios

Monodisperse lipid-coated microbubbles are a promising route to unlock the full potential of ultrasound contrast agents for medical diagnosis and therapy. Here, we present a stand-alone lab-on-a-chip instrument that allows microbubbles to…

Understanding the shell rheology of ultrasound contrast agent microbubbles is vital for anticipating their bioeffects in clinical practice. Past studies using sophisticated acoustic and optical techniques have made enormous progress in this…

Fluid Dynamics · Physics 2023-08-14 Marco Cattaneo , Outi Supponen

Understanding the pressure dependence of the nonlinear behavior of ultrasonically excited phospholipid (PL)-stabilized NBs is important for optimizing US exposure parameters for implementations of contrast enhanced ultrasound, critical to…

The problem of attenuation and sound speed of bubbly media has remained partially unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation and sound speed of a bubbly medium are not available. Our theoretical…

Fluid Dynamics · Physics 2022-09-20 AJ. Sojahrood , Q. Li , H. Haghi , R. Karshafian , T. M. Porter , M. C. Kolios

A way forward for high throughput fabrication of microcapsules with uniform size and mechanical properties was reported irrespective of the kinetic process of shell assembly. Microcapsules were produced using lab-scale emulsification…

Soft Condensed Matter · Physics 2021-02-12 Mehdi Maleki , Clément de Loubens , Kaili Xie , Emeline Talansier , Hugues Bodiguel , Marc Leonetti

Ultrasound is increasingly being used to modulate the properties of biological membranes for applications in drug delivery and neuromodulation. While various studies have investigated the mechanical aspect of the interaction such as…

Soft Condensed Matter · Physics 2018-11-19 Shamit Shrivastava , Robin O. Cleveland , Matthias F. Schneider

We demonstrate that the permeability of the cell wall of microalga $\textit{C. reinhardtii}$ can be enhanced in controlled microstreaming flow conditions using single bubbles adherent to a wall and driven by ultrasound near their resonance…

Quantitative Methods · Quantitative Biology 2021-12-20 Angelo Pommella , Irina Harun , Klaus Hellgardt , Valeria Garbin

Sensors based on whispering gallery resonators have minute footprints and can push achievable sensitivities and resolutions to their limits. Here, we use a microbubble resonator, with a wall thickness of 500 nm and an intrinsic Q-factor of…

Optics · Physics 2016-01-08 Yong Yang , Sunny Saurabh , Jonathan M Ward , Síle Nic Chormaic

Colloidal gels possess a memory of previous shear events, both steady and oscillatory. This memory, embedded in the microstructure, affects the mechanical response of the gel, and therefore enables precise tuning of the material properties…

Soft Condensed Matter · Physics 2022-03-10 Brice Saint-Michel , George Petekidis , Valeria Garbin

We present a computational study of the behaviour of a lipid-coated SonoVue microbubble with initial radius $1 \, \mu \text{m} \leq R_0 \leq 2 \, \mu \text{m}$, excited at frequencies (200-1500 kHz) significantly below the linear resonance…

Fluid Dynamics · Physics 2022-01-17 Jonas Gümmer , Sören Schenke , Fabian Denner

The mechanical properties of cells play key roles in their physiology, function, physiological and pathological transformations. Micro-elastography has recently emerged as a promising tool to estimate cellular viscoelastic properties within…

A variety of numerical methods exist for the study of deformable particles in dense suspensions. None of the standard tools, however, currently include volume-changing objects such as oscillating microbubbles in three-dimensional periodic…

Biological Physics · Physics 2017-08-14 Achim Guckenberger , Stephan Gekle

This review describes the analytical calculation of lateral pressure profile in lipid membrane with finite curvature. The derivation is based on the previously developed microscopic model of flexible strings [1,2]. According to this theory…

Soft Condensed Matter · Physics 2016-07-08 Anna A. Drozdova

Exploiting the full potential of MBs for applications requires a good understanding of their complex dynamics. Improved understanding of MB oscillations can lead to further enhancement in optimizing their efficacy in many applications and…

Applied Physics · Physics 2019-02-06 H. Haghi , AJ Sojahrood , M. C. Kolios

Locally (re)structuring colloidal gels $\unicode{x2013}$ micron-sized particles forming a connected network with arrested dynamics $\unicode{x2013}$ enables precise tuning of the micromechanical and -rheological properties of the system. A…

Soft Condensed Matter · Physics 2022-11-07 Kim William Torre , Joost de Graaf

The tunability of an optical cavity is an essential requirement for many areas of research. Here, we use the Pound-Drever-Hall technique to lock a laser to a whispering gallery mode (WGM) of a microbubble resonator, to show that linear…

Results of the measurements of sound speed and attenuation in a bubbly medium are reported. Monodisperse bubble solutions are sonicated with broadband ultrasound pulses with pressure amplitudes ranging between 12.5-100 kPa. Fundamental…

Fluid Dynamics · Physics 2018-11-20 A. J. Sojahrood , Q. Li , H. Haghi , R. Karshafian , T. M. Porter , M. C. Kolios

Contrast-enhanced ultrasound (CEUS) presents distinct advantages in diagnostic echography. Utilizing microbubbles (MBs) as conventional contrast agents enhances vascular visualization and organ perfusion, facilitating real-time,…

Medical Physics · Physics 2024-12-04 Agisilaos Matalliotakis , Martin D. Verweij
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