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We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. Self-assembly of protein domains by electrostatic lipid-protein interactions is contrasted with self-organization due to…

Cell Behavior · Quantitative Biology 2007-05-23 Karin John , Markus Baer

The cell cortex is a thin layer beneath the plasma membrane that gives animal cells mechanical resistance and drives most of their shape changes, from migration, division to multicellular morphogenesis. It is mainly composed of actin…

Biological Physics · Physics 2022-05-04 Hudson Borja da Rocha , Jérémy Bleyer , Hervé Turlier

Induced by proteins within the cell membrane or by differential growth, heating, or swelling, spontaneous curvatures can drastically affect the morphology of thin bodies and induce mechanical instabilities. Yet, the interaction of…

Soft Condensed Matter · Physics 2018-01-31 Matteo Pezzulla , Norbert Stoop , Mark P. Steranka , Abdikhalaq J. Bade , Douglas P. Holmes

We use virial series to study the equilibrium properties of confined soft-spheres fluids interacting through the inverse-power potentials. The confinement is induced by hard walls with planar, spherical and cylindrical shapes. We evaluate…

Soft Condensed Matter · Physics 2016-09-28 Ignacio Urrutia

Conforming materials to rigid substrates with Gaussian curvature --- positive for spheres and negative for saddles --- has proven a versatile tool to guide the self-assembly of defects such as scars, pleats, folds, blisters, and liquid…

Soft Condensed Matter · Physics 2017-10-03 Noah P. Mitchell , Vinzenz Koning , Vincenzo Vitelli , William T. M. Irvine

Granular materials show inhomogeneous flows characterized by strain localization. When strain is localized in a sheared granular material, rigid regions of a nearly undeformed state are separated by shear bands, where the material yields…

Soft Condensed Matter · Physics 2023-11-07 Aditya Pratap Singh , Vasileios Angelidakis , Thorsten Pöschel , Sudeshna Roy

Frustration arises for a broad class of physical systems where confinement (geometric) or the presence of a perturbation (kinematic) prevents equilibration to a minimum energy state. By varying the diameter ratio and packing fraction in…

Soft Condensed Matter · Physics 2019-11-28 David J. Schunter, , Matthew Boucher , Douglas P. Holmes

The shape of biological shells, such as cell nuclei, membranes, and vesicles, often deviates from a perfect sphere due to an interplay of complex interactions with a myriad of molecular structures. In particular, semiflexible biopolymers…

Soft Condensed Matter · Physics 2025-09-05 Hadiya Abdul Hameed , Jaroslaw Paturej , Aykut Erbas

Spatial organization of proteins in cells is important for many biological functions. In general, the nonlinear, spatially coupled models for protein-pattern formation are only accessible to numerical simulations, which has limited insight…

Pattern Formation and Solitons · Physics 2021-04-16 Fridtjof Brauns , Jacob Halatek , Erwin Frey

The elastic property of membranes self-assembled from AB diblock and ABA triblock copolymers, as coarse-grained model of lipids and the bolalipids, are studied using the self-consistent field theory (SCFT). Specifically, solutions of the…

Soft Condensed Matter · Physics 2019-05-17 Rui Xu , Ashkan Dehghan , An-Chang Shi , Jiajia Zhou

Fracture networks are ubiquitous in nature, spanning scales from millimeter-sized cracks in botanical peels to hundred-kilometer-long lineae on planetary satellites. The propagation of a crack is a complex, nonlinear phenomenon governed by…

Soft Condensed Matter · Physics 2026-03-25 Naoki Sekiya , Yuri Akiba , Kai Kageyama , Hokuto Nagatakiya , Ryuichi Tarumi , Tomohiko G. Sano

Phase-separated biomolecular condensates containing proteins and RNAs can assemble into higher-order structures by forming thermodynamically stable interfaces between immiscible phases. Using a minimal model of a protein/RNA interaction…

Soft Condensed Matter · Physics 2024-07-31 Tianhao Li , William M. Jacobs

Spatially confined rigid membranes reorganize their morphology in response to the imposed constraints. A crumpled elastic sheet presents a complex pattern of random folds focusing the deformation energy while compressing a membrane resting…

Cooperativity is a hallmark of proteins, many of which show a modular architecture comprising discrete structural domains. Detecting and describing dynamic couplings between structural regions is difficult in view of the many-body nature of…

Biological Physics · Physics 2015-02-03 Olga Kononova , Lee Jones , Valeri Barsegov

Spontaneous material shape changes, such as swelling, growth or thermal expansion, can be used to trigger dramatic elastic instabilities in thin shells. These instabilities originate in geometric incompatibility between the preferred…

Soft Condensed Matter · Physics 2022-04-18 Andrea Giudici , John S. Biggins

The macroscopic properties of polymeric fluids are inherited from the material properties of the fibers embedded in the solvent. The behavior of such passive fibers in flow has been of interest in a wide range of systems, including cellular…

Soft Condensed Matter · Physics 2019-06-20 John LaGrone , Ricardo Cortez , Wen Yan , Lisa Fauci

The rheological properties of biological tissues are core to processes such as cancer metastasis, wound healing and embryo development. The emergence of tissue and organ structures during morphogenesis requires the precise formation of…

Soft Condensed Matter · Physics 2026-03-10 Aidan J. Nicholas , Suzanne M. Fielding

Micropatterning techniques have become an important tool for the study of cell behavior in controlled microenvironments. As a consequence, several approaches for the creation of micropatterns have been developed in recent years. However,…

Biological Physics · Physics 2016-02-05 F. J. Segerer , P. J. F. Röttgermann , S. Schuster , A. Piera Alberola , S. Zahler , J. O. Rädler

Triangular lattice models for pattern formation by hard-core soft-shell particles at interfaces are introduced and studied in order to determine the effect of the shell thickness and structure. In model I, we consider particles with…

Soft Condensed Matter · Physics 2020-08-26 V. S. Grishina , V. S. Vikhrenko , A. Ciach

We study the interaction of small hydrophobic particles on the surface of an ultra-soft elastic gel, in which a small amount of elasticity of the medium balances the weights of the particles. The excess energy of the surface of the deformed…

Soft Condensed Matter · Physics 2014-06-09 Aditi Chakrabarti , Manoj K. Chaudhury