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There are several tools available to infer phylogenetic trees, which depict the evolutionary relationships among biological entities such as viral and bacterial strains in infectious outbreaks, or cancerous cells in tumor progression trees.…

Data Structures and Algorithms · Computer Science 2023-12-22 António Pedro Branco , Cátia Vaz , Alexandre P. Francisco

Here we show that deciding whether two rooted binary phylogenetic trees on the same set of taxa permit a cherry-picking sequence, a special type of elimination order on the taxa, is NP-complete. This improves on an earlier result which…

Populations and Evolution · Quantitative Biology 2021-04-13 Janosch Döcker , Leo van Iersel , Steven Kelk , Simone Linz

Phylogenetic trees play a key role in the reconstruction of evolutionary relationships. Typically, they are derived from aligned sequence data (like DNA, RNA, or proteins) by using optimization criteria like, e.g., maximum parsimony (MP).…

Populations and Evolution · Quantitative Biology 2025-06-11 Mirko Wilde , Mareike Fischer

A phylogenetic tree is a graphical representation of an evolutionary history of taxa in which the leaves correspond to the taxa and the non-leaves correspond to speciations. One of important problems in phylogenetic analysis is to assemble…

Combinatorics · Mathematics 2022-02-25 Hiroshi Hirai , Yuni Iwamasa

A Supertree synthesizes the topologies of a set of phylogenetic trees carrying overlapping taxa set. In process, conflicts in the tree topologies are aimed to be resolved with the consensus clades. Such a problem is proved to be NP-hard.…

Populations and Evolution · Quantitative Biology 2016-11-01 Sourya Bhattacharyya , Jayanta Mukhopadhyay

Consider a set of labels $L$ and a set of trees ${\mathcal T} = \{{\mathcal T}^{(1), {\mathcal T}^{(2), ..., {\mathcal T}^{(k) \$ where each tree ${\mathcal T}^{(i)$ is distinctly leaf-labeled by some subset of $L$. One fundamental problem…

Data Structures and Algorithms · Computer Science 2008-02-21 Viet Tung Hoang , Wing-Kin Sung

Phylogenetic trees are frequently used to model evolution. Such trees are typically reconstructed from data like DNA, RNA, or protein alignments using methods based on criteria like maximum parsimony (amongst others). Maximum parsimony has…

Populations and Evolution · Quantitative Biology 2023-07-31 Mirko Wilde , Mareike Fischer

In comparison to phylogenetic trees, phylogenetic networks are more suitable to represent complex evolutionary histories of species whose past includes reticulation such as hybridisation or lateral gene transfer. However, the reconstruction…

Populations and Evolution · Quantitative Biology 2024-05-31 Janosch Döcker , Simone Linz , Kristina Wicke

We present an algorithm for computing a maximum agreement subtree of two unrooted evolutionary trees. It takes O(n^{1.5} log n) time for trees with unbounded degrees, matching the best known time complexity for the rooted case. Our…

Computational Engineering, Finance, and Science · Computer Science 2007-05-23 Ming-Yang Kao , Tak-Wah Lam , Wing-Kin Sung , Hing-Fung Ting

The relationship between two important problems in tree pattern matching, the largest common subtree and the smallest common supertree problems, is established by means of simple constructions, which allow one to obtain a largest common…

Data Structures and Algorithms · Computer Science 2007-05-23 Francesc Rossello , Gabriel Valiente

Compatibility of phylogenetic trees is the most important concept underlying widely-used methods for assessing the agreement of different phylogenetic trees with overlapping taxa and combining them into common supertrees to reveal the tree…

Discrete Mathematics · Computer Science 2011-11-09 Merce Llabres , Jairo Rocha , Francesc Rossello , Gabriel Valiente

Phylogenetic networks are often constructed by merging multiple conflicting phylogenetic signals into a directed acyclic graph. It is interesting to explore whether a network constructed in this way induces biologically-relevant…

Populations and Evolution · Quantitative Biology 2017-07-13 Steven Kelk , Fabio Pardi , Celine Scornavacca , Leo van Iersel

Many popular algorithms for searching the space of leaf-labelled trees are based on tree rearrangement operations. Under any such operation, the problem is reduced to searching a graph where vertices are trees and (undirected) edges are…

Data Structures and Algorithms · Computer Science 2020-07-27 Lena Collienne , Alex Gavryushkin

Phylogenetic trees canonically arise as embeddings of phylogenetic networks. We recently showed that the problem of deciding if two phylogenetic networks embed the same sets of phylogenetic trees is computationally hard, \blue{in…

Combinatorics · Mathematics 2021-04-13 Janosch Doecker , Simone Linz , Charles Semple

We find an orientation of a tree with 20 vertices such that the corresponding fixed-template constraint satisfaction problem (CSP) is NP-complete, and prove that for every orientation of a tree with fewer vertices the corresponding CSP can…

Rings and Algebras · Mathematics 2023-03-28 Manuel Bodirsky , Jakub Bulín , Florian Starke , Michael Wernthaler

Phylogenetic networks are leaf-labelled directed acyclic graphs that are used to describe non-treelike evolutionary histories and are thus a generalization of phylogenetic trees. The hybridization number of a phylogenetic network is the sum…

Data Structures and Algorithms · Computer Science 2016-06-01 Leo van Iersel , Steven Kelk , Nela Lekić , Chris Whidden , Norbert Zeh

It has recently been shown that the NP-hard problem of calculating the minimum number of hybridization events that is needed to explain a set of rooted binary phylogenetic trees by means of a hybridization network is fixed-parameter…

Populations and Evolution · Quantitative Biology 2012-03-20 Leo van Iersel , Simone Linz

The reconstruction of phylogenetic networks is an important but challenging problem in phylogenetics and genome evolution, as the space of phylogenetic networks is vast and cannot be sampled well. One approach to the problem is to solve the…

Populations and Evolution · Quantitative Biology 2023-04-14 Louxin Zhang , Niloufar Abhari , Caroline Colijn , Yufeng Wu

In the longest plane spanning tree problem, we are given a finite planar point set $\mathcal{P}$, and our task is to find a plane (i.e., noncrossing) spanning tree for $\mathcal{P}$ with maximum total Euclidean edge length. Despite more…

Computational Geometry · Computer Science 2024-05-02 Sergio Cabello , Michael Hoffmann , Katharina Klost , Wolfgang Mulzer , Josef Tkadlec

Phylogenetic networks are increasingly being considered as better suited to represent the complexity of the evolutionary relationships between species. One class of phylogenetic networks that has received a lot of attention recently is the…

Data Structures and Algorithms · Computer Science 2023-05-02 Kaari Landry , Olivier Tremblay-Savard , Manuel Lafond