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Predicting individualized potential outcomes in sequential decision-making is central for optimizing therapeutic decisions in personalized medicine (e.g., which dosing sequence to give to a cancer patient). However, predicting potential…

Reliable uncertainty quantification (UQ) is essential when employing large language models (LLMs) in high-risk domains such as clinical question answering (QA). In this work, we evaluate uncertainty estimation methods for clinical QA…

Computation and Language · Computer Science 2026-01-27 Alberto Testoni , Iacer Calixto

Tailoring treatment for individual patients is crucial yet challenging in order to achieve optimal healthcare outcomes. Recent advances in reinforcement learning offer promising personalized treatment recommendations; however, they rely…

Machine Learning · Computer Science 2023-07-06 Simin Ma , Junghwan Lee , Nicoleta Serban , Shihao Yang

This paper introduces a novel stochastic control framework to enhance the capabilities of automated investment managers, or robo-advisors, by accurately inferring clients' investment preferences from past activities. Our approach leverages…

Optimization and Control · Mathematics 2024-06-05 Haoyang Cao , Zhengqi Wu , Renyuan Xu

Large Language Models (LLMs) have demonstrated remarkable capability in a variety of NLP tasks. However, LLMs are also prone to generate nonfactual content. Uncertainty Quantification (UQ) is pivotal in enhancing our understanding of a…

Computation and Language · Computer Science 2024-10-07 Caiqi Zhang , Fangyu Liu , Marco Basaldella , Nigel Collier

We develop methodology for a multistage decision problem with flexible number of stages in which the rewards are survival times that are subject to censoring. We present a novel Q-learning algorithm that is adjusted for censored data and…

Statistics Theory · Mathematics 2012-05-31 Yair Goldberg , Michael R. Kosorok

Q-learning facilitates the development of an optimal adaptive treatment strategy through stagewise regression on a pre-specified set of tailoring variables and confounders. Semiparametric robust Q-learning eliminates the residual…

Dynamic treatment regimens (DTRs) are sequential decision rules tailored at each stage by potentially time-varying patient features and intermediate outcomes observed in previous stages. The complexity, patient heterogeneity and chronicity…

Methodology · Statistics 2016-11-09 Ying Liu , Yuanjia Wang , Michael R. Kosorok , Yingqi Zhao , Donglin Zeng

This paper addresses the challenge of jointly modeling user intent diversity and behavioral uncertainty in recommender systems. A unified representation learning framework is proposed. The framework builds a multi-intent representation…

Information Retrieval · Computer Science 2025-09-08 Wei Xu , Jiasen Zheng , Junjiang Lin , Mingxuan Han , Junliang Du

Ubiquitous information access becomes more and more important nowadays and research is aimed at making it adapted to users. Our work consists in applying machine learning techniques in order to bring a solution to some of the problems…

Machine Learning · Computer Science 2014-04-01 Djallel Bouneffouf

Reinforcement learning (RL) has seen significant research and application results but often requires large amounts of training data. This paper proposes two data-efficient off-policy RL methods that use parametrized Q-learning. In these…

Systems and Control · Electrical Eng. & Systems 2025-04-09 J. S. van Hulst , W. P. M. H. Heemels , D. J. Antunes

Large language models (LLMs) exhibit impressive fluency, but often produce critical errors known as "hallucinations". Uncertainty quantification (UQ) methods are a promising tool for coping with this fundamental shortcoming. Yet, existing…

High-dimensional multivariate longitudinal data, which arise when many outcome variables are measured repeatedly over time, are becoming increasingly common in social, behavioral and health sciences. We propose a latent variable model for…

Methodology · Statistics 2025-12-09 Sze Ming Lee , Yunxiao Chen , Tony Sit

Reinforcement learning (RL) is increasingly being used in the healthcare domain, particularly for the development of personalized health adaptive interventions. Inspired by the success of Large Language Models (LLMs), we are interested in…

Machine Learning · Computer Science 2025-01-14 Karine Karine , Benjamin M. Marlin

Health policy decisions regarding patient treatment strategies require consideration of both treatment effectiveness and cost. Optimizing treatment rules with respect to effectiveness may result in prohibitively expensive strategies; on the…

Methodology · Statistics 2021-10-20 Nicholas Illenberger , Andrew J. Spieker , Nandita Mitra

Quantum neural networks combine quantum computing with advanced data-driven methods, offering promising applications in quantum machine learning. However, the optimal paradigm for balancing trainability and expressivity in QNNs remains an…

Quantum Physics · Physics 2025-08-05 Hongshun Yao , Xia Liu , Mingrui Jing , Guangxi Li , Xin Wang

Predicting whether a treatment leads to meaningful improvement is a central challenge in personalized medicine, particularly when disease progression manifests as subtle visual changes over time. While data-driven deep learning (DL) offers…

Image and Video Processing · Electrical Eng. & Systems 2025-11-21 Jana Armouti , Nikhil Madaan , Rohan Panda , Tom Fox , Laura Hutchins , Amita Krishnan , Ricardo Rodriguez , Bennett DeBoisblanc , Deva Ramanan , John Galeotti , Gautam Gare

Humans often juggle multiple, sometimes conflicting objectives and shift their priorities as circumstances change, rather than following a fixed objective function. In contrast, most computational decision-making and multi-objective RL…

Artificial Intelligence · Computer Science 2026-03-25 Xianwei Cao , Dou Quan , Zhenliang Zhang , Shuang Wang

In recent years, significant progress has been made in multi-objective reinforcement learning (RL) research, which aims to balance multiple objectives by incorporating preferences for each objective. In most existing studies, specific…

Machine Learning · Computer Science 2024-09-17 Qian Lin , Zongkai Liu , Danying Mo , Chao Yu

Client heterogeneity poses significant challenges to the performance of Quantum Federated Learning (QFL). To overcome these limitations, we propose a new approach leveraging deep unfolding, which enables clients to autonomously optimize…

Machine Learning · Computer Science 2025-06-26 Shanika Iroshi Nanayakkara , Shiva Raj Pokhrel