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The current manuscript introduce a single-strain dengue model developed from stochastic processes incorporating fractional order transmission and recovery. The fractional derivative has been introduced within the context of transmission and…

Dynamical Systems · Mathematics 2024-10-28 Tahajuddin Sk , Kaushik Bal , Santosh Biswas , Tridip Sardar

This paper introduces a new optimal control model to describe and control the dynamics of infectious diseases. In the present model, the average time of isolation (i.e. hospitalization) of infectious population is the main time-dependent…

Optimization and Control · Mathematics 2015-05-06 Robin J. Evans , Musa Mammadov

This paper revisits a longstanding problem of interest concerning the distributed control of an epidemic process on human contact networks. Due to the stochastic nature and combinatorial complexity of the problem, finding optimal policies…

Optimization and Control · Mathematics 2022-12-12 Mohammad Mubarak , Cameron Nowzari

We study first order necessary conditions for an optimal control problem of a Susceptible-Infected-Recovered (SIR) model with limitations on the duration of the quarantine. The control is done by means of the reproduction number, i.e., the…

This paper presents a discrete time probabilistic dynamic for simulating a contact-based epidemic spreading based on discrete time Markov chain process, in particular the attention is addressed to the susceptible-infectious-removed (SIR)…

Physics and Society · Physics 2017-12-22 Fabrizio Angaroni

In 2009, for the first time in Cape Verde, an outbreak of dengue was reported and over twenty thousand people were infected. Only a few prophylactic measures were taken. The effects of vector control on disease spreading, such as…

Optimization and Control · Mathematics 2013-10-03 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres

This work introduces a novel epidemiological model that simultaneously considers multiple viral strains, reinfections due to waning immunity response over time and an optimal control formulation. This enables us to derive optimal mitigation…

Systems and Control · Electrical Eng. & Systems 2021-09-10 Edilson F. Arruda , Dayse H. Pastore , Clauda M. Dias , Shyam S. Das

In recent years the spread of the ectoparasitic mite Varroa destructor has become the most serious threat to worldwide apiculture. In the model presented here we extend the bee population dynamics with mite viral epidemiology examined in an…

Populations and Evolution · Quantitative Biology 2016-09-15 Sara Bernardi , Ezio Venturino

This paper investigates a behavioral-feedback SIR model in which the infection rate adapts dynamically based on the fractions of susceptible and infected individuals. We introduce an invariant of motion and we characterize the peak of…

Populations and Evolution · Quantitative Biology 2025-09-17 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani , Francesca Parise

Managing infectious diseases is a world public health issue, plagued by uncertainties. In this paper, we analyze the problem of viable control of a dengue outbreak under uncertainty. For this purpose, we develop a controlled Ross-Macdonald…

Optimization and Control · Mathematics 2018-02-23 Lilian Sofia Salcedo Sepulveda , Michel De Lara

Malaria is a serious global health problem which is especially devastating to the developing world. Mosquitoes are the carriers of the parasite responsible for the disease, and hence malaria control programs focus on controlling mosquito…

Dynamical Systems · Mathematics 2016-06-17 Bhushan Kotnis , Joy Kuri

Dengue is a vector-borne disease and 40% of world population is at risk. Dengue transcends international borders and can be found in tropical and subtropical regions around the world, predominantly in urban and semi-urban areas. A model for…

Populations and Evolution · Quantitative Biology 2016-08-10 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres , Ana Clara Silva , Carla Sousa , Cláudia Conceição

We provide easy and readable GNU Octave/MATLAB code for the simulation of mathematical models described by ordinary differential equations and for the solution of optimal control problems through Pontryagin's maximum principle. For that, we…

Optimization and Control · Mathematics 2019-12-23 Carlos Campos , Cristiana J. Silva , Delfim F. M. Torres

Ebola virus is one of the most virulent pathogens for humans. We present a mathematical description of different Susceptible-Exposed-Infectious-Recovered (SEIR) models. By using mathematical modeling and analysis, the latest major outbreak…

Populations and Evolution · Quantitative Biology 2017-08-01 Amira Rachah , Delfim F. M. Torres

We propose and analyze a new class of controlled multi-type branching processes with a per-step linear resource constraint, motivated by potential applications in viral marketing and cancer treatment. We show that the optimal exponential…

Optimization and Control · Mathematics 2013-01-09 Shie Mannor , Kuang Xu

Wolbachia, a maternally transmitted endosymbiont, offers a powerful biological control strategy for mosquito-borne diseases such as dengue, Zika, and malaria. We develop an integro-difference equation (IDE) model that integrates Wolbachia's…

Populations and Evolution · Quantitative Biology 2026-01-27 Zhuolin Qu , Tong Wu , Eddy Kwessi

This paper studies an optimal control problem for a class of SIR epidemic models, in scenarios in which the infected population is constrained to be lower than a critical threshold imposed by the ICU (intensive care unit) capacity. The…

Optimization and Control · Mathematics 2024-12-31 Matteo Della Rossa , Lorenzo Freddi , Dan Goreac

We propose an SEIR model for the populations and an SEI model for the vector to describe the transmission dynamics of a four-strain model with both primary and secondary dengue infections. In order to accomplish this, we propose and obtain…

Populations and Evolution · Quantitative Biology 2014-06-18 Raul Isea

Vaccination has been proven to be the most effective method to prevent infectious diseases. However, in many low and middle-income countries with geographically dispersed and nomadic populations, last-mile vaccine delivery can be extremely…

Applications · Statistics 2021-04-30 Yuwen Yang , Jayant Rajgopal

We study an optimal control problem for a non-autonomous SEIRS model with incidence given by a general function of the infective, the susceptible and the total population, and with vaccination and treatment as control variables. We prove…

Optimization and Control · Mathematics 2018-06-13 Joaquim P. Mateus , Paulo Rebelo , Silvério Rosa , César M. Silva , Delfim F. M. Torres