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We study the problem of deconvolution for light-sheet microscopy, where the data is corrupted by spatially varying blur and a combination of Poisson and Gaussian noise. The spatial variation of the point spread function (PSF) of a…

Building generalized models that can solve many computer vision tasks simultaneously is an intriguing direction. Recent works have shown image itself can be used as a natural interface for general-purpose visual perception and demonstrated…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Yue Fan , Yongqin Xian , Xiaohua Zhai , Alexander Kolesnikov , Muhammad Ferjad Naeem , Bernt Schiele , Federico Tombari

The ability to generate physically plausible ensembles of variable sources is critical to the optimization of time-domain survey cadences and the training of classification models on datasets with few to no labels. Traditional data…

Instrumentation and Methods for Astrophysics · Physics 2020-05-19 Jorge Martínez-Palomera , Joshua S. Bloom , Ellianna S. Abrahams

Recent image generation models show remarkable generation performance. However, they mirror strong location preference in datasets, which we call spatial bias. Therefore, generators render poor samples at unseen locations and scales. We…

Machine Learning · Computer Science 2021-08-04 Jooyoung Choi , Jungbeom Lee , Yonghyun Jeong , Sungroh Yoon

We describe a rapid and direct method for regularizing, post-facto, the point-spread function (PSF) of a telescope or other imaging instrument, across its entire field of view. Imaging instruments in general blur point sources of light by…

Instrumentation and Methods for Astrophysics · Physics 2023-03-20 J. M. Hughes , C. E. DeForest , D. B. Seaton

A new method for improving the resolution of astronomical images is presented. It is based on the principle that sampled data cannot be fully deconvolved without violating the sampling theorem. Thus, the sampled image should not be…

Astrophysics · Physics 2009-10-30 P. Magain , F. Courbin , S. Sohy

Diffusion-based generative models learn to iteratively transfer unstructured noise to a complex target distribution as opposed to Generative Adversarial Networks (GANs) or the decoder of Variational Autoencoders (VAEs) which produce samples…

Machine Learning · Computer Science 2022-10-26 Sarthak Mittal , Guillaume Lajoie , Stefan Bauer , Arash Mehrjou

We introduce a framework for joint grounded scene graph - image generation, a challenging task involving high-dimensional, multi-modal structured data. To effectively model this complex joint distribution, we adopt a factorized approach:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Bicheng Xu , Qi Yan , Renjie Liao , Lele Wang , Leonid Sigal

Diffusion models excel at capturing the natural design spaces of images, molecules, DNA, RNA, and protein sequences. However, rather than merely generating designs that are natural, we often aim to optimize downstream reward functions while…

In astronomy, upcoming space telescopes with wide-field optical instruments have a spatially varying point spread function (PSF). Specific scientific goals require a high-fidelity estimation of the PSF at target positions where no direct…

Instrumentation and Methods for Astrophysics · Physics 2023-02-22 Tobias Liaudat , Jean-Luc Starck , Martin Kilbinger , Pierre-Antoine Frugier

This Point spread function (PSF) plays a crucial role in many computational imaging applications, such as shape from focus/defocus, depth estimation, and fluorescence microscopy. However, the mathematical model of the defocus process is…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Renzhi He , Yan Zhuang , Boya Fu , Fei Liu

In recent years, diffusion models (DMs) have become a popular method for generating synthetic data. By achieving samples of higher quality, they quickly became superior to generative adversarial networks (GANs) and the current…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Denisa Qosja , Simon Wagner , Daniel O'Hagan

Classifier guidance is a recently introduced method to trade off mode coverage and sample fidelity in conditional diffusion models post training, in the same spirit as low temperature sampling or truncation in other types of generative…

Machine Learning · Computer Science 2022-07-27 Jonathan Ho , Tim Salimans

We present a new technique for monitoring microlensing activity even in highly crowded fields, and use this technique to place limits on low-mass MACHOs in the haloes of M31 and the Galaxy. Unlike present Galactic microlensing surveys, we…

Astrophysics · Physics 2009-09-28 Austin B. Tomaney , Arlin P. S. Crotts

Diffusion models have emerged as powerful tools for high-quality image generation and editing, but guiding these models to produce specific outputs remains a challenge. Conventional approaches rely on conditioning mechanisms, such as text…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Nithesh Chandher Karthikeyan , Jonas Unger , Gabriel Eilertsen

Diffusion probabilistic models have been successful in generating high-quality and diverse images. However, traditional models, whose input and output are high-resolution images, suffer from excessive memory requirements, making them less…

Computer Vision and Pattern Recognition · Computer Science 2023-04-17 Shinei Arakawa , Hideki Tsunashima , Daichi Horita , Keitaro Tanaka , Shigeo Morishima

High-throughput phenotypic screens generate vast microscopy image datasets that push the limits of generative models due to their large dimensionality. Despite the growing popularity of general-purpose models trained on natural images for…

Quantitative Methods · Quantitative Biology 2025-10-24 Télio Cropsal , Rocío Mercado

Diffusion probabilistic models excel at sampling new images from learned distributions. Originally motivated by drift-diffusion concepts from physics, they apply image perturbations such as noise and blur in a forward process that results…

Image and Video Processing · Electrical Eng. & Systems 2024-06-07 Pascal Peter

This paper proposes DiffPF, a differentiable particle filter that leverages diffusion models for state estimation in dynamic systems. Unlike conventional differentiable particle filters, which require importance weighting and typically rely…

Robotics · Computer Science 2026-01-13 Ziyu Wan , Lin Zhao

Standard diffusion models involve an image transform -- adding Gaussian noise -- and an image restoration operator that inverts this degradation. We observe that the generative behavior of diffusion models is not strongly dependent on the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-22 Arpit Bansal , Eitan Borgnia , Hong-Min Chu , Jie S. Li , Hamid Kazemi , Furong Huang , Micah Goldblum , Jonas Geiping , Tom Goldstein