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To discover new drugs is to seek and to prove causality. As an emerging approach leveraging human knowledge and creativity, data, and machine intelligence, causal inference holds the promise of reducing cognitive bias and improving decision…

Quantitative Methods · Quantitative Biology 2025-04-09 Tom Michoel , Jitao David Zhang

A typical problem in causal modeling is the instability of model structure learning, i.e., small changes in finite data can result in completely different optimal models. The present work introduces a novel causal modeling algorithm for…

Consider the problem of learning, from non-experimental data, the causal (Markov equivalence) structure of the true, unknown causal Bayesian network (CBN) on a given, fixed set of (categorical) variables. This learning problem is known to…

Machine Learning · Statistics 2025-02-26 Hanti Lin , Jiji Zhang

Causality is a fundamental part of the scientific endeavour to understand the world. Unfortunately, causality is still taboo in much of psychology and social science. Motivated by a growing number of recommendations for the importance of…

Methodology · Statistics 2022-06-27 Matthew J. Vowels

Learning causal relationships from time series data is an important but challenging problem. Existing synthetic datasets often contain hidden artifacts that can be exploited by causal discovery methods, reducing their usefulness for…

Machine Learning · Computer Science 2026-03-23 Xiaoyu He , Petr Ryšavý , Jakub Mareček

Causal effect estimation from observational data is a crucial but challenging task. Currently, only a limited number of data-driven causal effect estimation methods are available. These methods either provide only a bound estimation of the…

Methodology · Statistics 2020-11-10 Debo Cheng , Jiuyong Li , Lin Liu , Kui Yu , Thuc Duy Lee , Jixue Liu

Models that learn spurious correlations from training data often fail when deployed in new environments. While many methods aim to learn invariant representations to address this, they often underperform standard empirical risk minimization…

Machine Learning · Computer Science 2025-11-11 Ruqi Bai , Yao Ji , Zeyu Zhou , David I. Inouye

Synthetic data generation has been widely adopted in software testing, data privacy, imbalanced learning, and artificial intelligence explanation. In all such contexts, it is crucial to generate plausible data samples. A common assumption…

Artificial Intelligence · Computer Science 2024-10-16 Martina Cinquini , Fosca Giannotti , Riccardo Guidotti

Scaling laws have allowed Pre-trained Language Models (PLMs) into the field of causal reasoning. Causal reasoning of PLM relies solely on text-based descriptions, in contrast to causal discovery which aims to determine the causal…

This paper provides statistical sample complexity bounds for score-matching and its applications in causal discovery. We demonstrate that accurate estimation of the score function is achievable by training a standard deep ReLU neural…

Machine Learning · Computer Science 2023-10-30 Zhenyu Zhu , Francesco Locatello , Volkan Cevher

A recent trend of fair machine learning is to define fairness as causality-based notions which concern the causal connection between protected attributes and decisions. However, one common challenge of all causality-based fairness notions…

Machine Learning · Computer Science 2019-10-29 Yongkai Wu , Lu Zhang , Xintao Wu , Hanghang Tong

Given data sampled from a number of variables, one is often interested in the underlying causal relationships in the form of a directed acyclic graph. In the general case, without interventions on some of the variables it is only possible…

Machine Learning · Statistics 2017-12-05 Christopher Nowzohour , Peter Bühlmann

Much of scientific data is collected as randomized experiments intervening on some and observing other variables of interest. Quite often, a given phenomenon is investigated in several studies, and different sets of variables are involved…

Methodology · Statistics 2012-10-19 Antti Hyttinen , Frederick Eberhardt , Patrik O. Hoyer

Causal discovery, the problem of inferring the direction of causality, is generally ill-posed. We use the language of structural causal models (SCM) to show that assuming that the causal relations are acyclic and invariant across multiple…

Machine Learning · Statistics 2026-05-14 Francesco Montagna , Francesco Locatello

This paper discusses the problem of causal query in observational data with hidden variables, with the aim of seeking the change of an outcome when "manipulating" a variable while given a set of plausible confounding variables which affect…

Artificial Intelligence · Computer Science 2020-11-25 Debo Cheng , Jiuyong Li , Lin Liu , Jixue Liu , Kui Yu , Thuc Duy Le

Machine learning algorithms are designed to capture complex relationships between features. In this context, the high dimensionality of data often results in poor model performance, with the risk of overfitting. Feature selection, the…

Machine Learning · Computer Science 2023-10-18 Paolo Bonetti , Alberto Maria Metelli , Marcello Restelli

There are many different causal effect estimators in causal inference. However, it is unclear how to choose between these estimators because there is no ground-truth for causal effects. A commonly used option is to simulate synthetic data,…

Machine Learning · Computer Science 2021-03-30 Brady Neal , Chin-Wei Huang , Sunand Raghupathi

Constraint-based causal discovery from limited data is a notoriously difficult challenge due to the many borderline independence test decisions. Several approaches to improve the reliability of the predictions by exploiting redundancy in…

Machine Learning · Computer Science 2017-01-27 Sara Magliacane , Tom Claassen , Joris M. Mooij

When causal quantities cannot be point identified, researchers often pursue partial identification to quantify the range of possible values. However, the peculiarities of applied research conditions can make this analytically intractable.…

Methodology · Statistics 2021-09-29 Guilherme Duarte , Noam Finkelstein , Dean Knox , Jonathan Mummolo , Ilya Shpitser

Recommending the best course of action for an individual is a major application of individual-level causal effect estimation. This application is often needed in safety-critical domains such as healthcare, where estimating and communicating…

Machine Learning · Computer Science 2020-10-26 Andrew Jesson , Sören Mindermann , Uri Shalit , Yarin Gal