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Traditional image-based survival prediction models rely on discriminative patch labeling which make those methods not scalable to extend to large datasets. Recent studies have shown Multiple Instance Learning (MIL) framework is useful for…
We propose a new formulation of Multiple-Instance Learning (MIL). In typical MIL settings, a unit of data is given as a set of instances called a bag and the goal is to find a good classifier of bags based on similarity from a single or…
Weakly-supervised classification of histopathology slides is a computationally intensive task, with a typical whole slide image (WSI) containing billions of pixels to process. We propose Discriminative Region Active Sampling for Multiple…
Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS)…
Multiple instance learning (MIL) has enabled substantial progress in computational histopathology, where a large amount of patches from gigapixel whole slide images are aggregated into slide-level predictions. Heatmaps are widely used to…
Despite being resource-intensive to train, 3D convolutional neural networks (CNNs) have been the standard approach to classify CT and MRI scans. Recent work suggests that deep multiple instance learning (MIL) may be a more efficient…
Multiple Instance Learning (MIL) is a popular weakly-supervised method for various applications, with a particular interest in histological whole slide image (WSI) classification. Due to the gigapixel resolution of WSI, applications of MIL…
Computational pathology (CPath) has significantly advanced the clinical practice of pathology. Despite the progress made, Multiple Instance Learning (MIL), a promising paradigm within CPath, continues to face challenges, particularly…
Learning representations for individual instances when only bag-level labels are available is a fundamental challenge in multiple instance learning (MIL). Recent works have shown promising results using contrastive self-supervised learning…
Whole slide image (WSI) classification is a fundamental task for the diagnosis and treatment of diseases; but, curation of accurate labels is time-consuming and limits the application of fully-supervised methods. To address this, multiple…
Intracranial hemorrhage (ICH) is a life-threatening condition that requires rapid and accurate diagnosis to improve treatment outcomes and patient survival rates. Recent advancements in supervised deep learning have greatly improved the…
Graph-based Multiple Instance Learning (MIL) is widely used in survival analysis with Hematoxylin and Eosin (H\&E)-stained whole slide images (WSIs) due to its ability to capture topological information. However, variations in staining and…
With the increasing demand for histopathological specimen examination and diagnostic reporting, Multiple Instance Learning (MIL) has received heightened research focus as a viable solution for AI-centric diagnostic aid. Recently, to improve…
In recent years, the integration of pre-trained foundational models with multiple instance learning (MIL) has improved diagnostic accuracy in computational pathology. However, existing MIL methods focus on optimizing feature extractors and…
Sebocytes are lipid-secreting cells whose differentiation is marked by the accumulation of intracellular lipid droplets, making their quantification a key readout in sebocyte biology. Manual counting is labor-intensive and subjective,…
Detecting anomalies over real-world datasets remains a challenging task. Data annotation is an intensive human labor problem, particularly in sequential datasets, where the start and end time of anomalies are not known. As a result, data…
Multiple instance learning (MIL) is often used in medical imaging to classify high-resolution 2D images by processing patches or classify 3D volumes by processing slices. However, conventional MIL approaches treat instances separately,…
Modern machine learning pipelines, in particular those based on deep learning (DL) models, require large amounts of labeled data. For classification problems, the most common learning paradigm consists of presenting labeled examples during…
We consider machine-learning-based thyroid-malignancy prediction from cytopathology whole-slide images (WSI). Multiple instance learning (MIL) approaches, typically used for the analysis of WSIs, divide the image (bag) into patches…
Multiple-instance learning (MIL) has served as an important tool for a wide range of vision applications, for instance, image classification, object detection, and visual tracking. In this paper, we propose a novel method to solve the…