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We study the effect of correlations in generation times on the dynamics of population growth of microorganisms. We show that any non-zero correlation that is due to cell-size regulation, no matter how small, induces long-term oscillations…

Populations and Evolution · Quantitative Biology 2019-03-27 Farshid Jafarpour

We consider a model for the dynamics of growing cell populations with heterogeneous mobility and proliferation rate. The cell phenotypic state is described by a continuous structuring variable and the evolution of the local cell population…

Analysis of PDEs · Mathematics 2021-05-20 Tommaso Lorenzi , Benoît Perthame , Xinran Ruan

We present new algorithm for growth of non-clustered planar graphs by aggregation of cells with given distribution of size and constraint of connectivity k=3 per node. The emergent graph structures are controlled by two parameters--chemical…

Statistical Mechanics · Physics 2007-05-23 Milovan Suvakov , Bosiljka Tadic

Cell sorting, whereby a heterogeneous cell mixture segregates and forms distinct homogeneous tissues, is one of the main collective cell behaviors at work during development. Although differences in interfacial energies are recognized to be…

Soft Condensed Matter · Physics 2022-07-15 Marc Durand

During the last decades, medical observations and multiscale data concerning tumor growth are mounting. At the same time, contemporary imaging techniques well established in clinical practice, provide a variety of information on real-time,…

Tissues and Organs · Quantitative Biology 2017-12-11 Markos Antonopoulos , Georgios Stamatakos

A model of multicellular systems with several types of cells is developed from the phase field model. The model is presented as a set of partial differential equations of the field variables, each of which expresses the shape of one cell.…

Biological Physics · Physics 2015-05-30 Makiko Nonomura

We construct a matrix model equivalent (exactly, not asymptotically), to the random plane partition model, with almost arbitrary boundary conditions. Equivalently, it is also a random matrix model for a TASEP-like process with arbitrary…

Mathematical Physics · Physics 2009-11-13 Bertrand Eynard

A rigorous methodology is proposed to study cell division data consisting in several observed genealogical trees of possibly different shapes. The procedure takes into account missing observations, data from different trees, as well as the…

Applications · Statistics 2013-04-15 Benoîte de Saporta , Anne Gégout Petit , Laurence Marsalle

Many models of population dynamics are formulated as deterministic iterated maps although real populations are stochastic. This is justifiable in the limit of large population sizes, as the stochastic fluctuations are negligible then.…

Populations and Evolution · Quantitative Biology 2025-09-16 Snehal M. Shekatkar

The life of a cell is governed by highly dynamical microscopic processes. Two notable examples are the diffusion of membrane receptors and the kinetics of transcription factors governing the rates of gene expression. Different fluorescence…

Quantitative Methods · Quantitative Biology 2020-04-03 Maxime Woringer , Ignacio Izeddin , Cyril Favard , Hugues Berry

Recent studies at individual cell resolution have revealed phenotypic heterogeneity in nominally clonal tumor cell populations. The heterogeneity affects cell growth behaviors, which can result in departure from the idealized uniform…

Populations and Evolution · Quantitative Biology 2023-10-20 Yue Wang , Joseph X. Zhou , Edoardo Pedrini , Irit Rubin , May Khalil , Roberto Taramelli , Hong Qian , Sui Huang

We consider the long-time behavior of an explicit tamed Euler scheme applied to a class of stochastic differential equations driven by additive noise, under a one-sided Lipschitz continuity condition. The setting encompasses drift…

Numerical Analysis · Mathematics 2020-10-02 Charles-Edouard Bréhier

The totally asymmetric simple exclusion process (TASEP) is a paradigmatic stochastic model for non-equilibrium physics, and has been successfully applied to describe active transport of molecular motors along cytoskeletal filaments.…

Biological Physics · Physics 2018-07-25 Mareike Bojer , Isabella R. Graf , Erwin Frey

We study the dynamics of (synchronous) one-dimensional cellular automata with cyclical boundary conditions that evolve according to the majority rule with radius $ r $. We introduce a notion that we term cell stability with which we express…

Discrete Mathematics · Computer Science 2022-06-06 Yonatan Nakar , Dana Ron

We study a simple deterministic map that leads a fully connected network to Heider balance. The map is realized by an algorithm that updates all links synchronously in a way depending on the state of the entire network. We observe that the…

Cellular Automata and Lattice Gases · Physics 2021-08-18 Malgorzata J. Krawczyk , Krzysztof Kulakowski , Zdzislaw Burda

Using demographic data of high spatial resolution for a region in the south of Europe, we study the population over fixed-size spatial cells. We find that, counterintuitively, the distribution of the number of inhabitants per cell increases…

Physics and Society · Physics 2022-12-07 Alvaro Corral , Montserrat García del Muro

Microtubule asters - radial arrays of microtubules organized by centrosomes - play a fundamental role in the spatial coordination of animal cells. The standard model of aster growth assumes a fixed number of microtubules originating from…

Subcellular Processes · Quantitative Biology 2018-07-02 Keisuke Ishihara , Kirill S. Korolev , Timothy J. Mitchison

In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or…

Analysis of PDEs · Mathematics 2013-06-11 Martin Kohlmann

Graphs are ubiquitous data structures for representing interactions between entities. With an emphasis on the use of graphs to represent chemical molecules, we explore the task of learning to generate graphs that conform to a distribution…

Machine Learning · Computer Science 2019-03-08 Qi Liu , Miltiadis Allamanis , Marc Brockschmidt , Alexander L. Gaunt

We analytically compute asymptotic expansions of a 1-dimensional sub-manifold of stable and unstable manifolds in a 4-dimensional symplectic mapping by using the method called asymptotic expansions beyond all orders. This method enables us…

chao-dyn · Physics 2007-05-23 Yoshihiro Hirata , Tetsuro Konishi