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Clinical trials are indispensable for medical research and the development of new treatments. However, clinical trials often involve thousands of participants and can span several years to complete, with a high probability of failure during…

Machine Learning · Computer Science 2024-07-02 Yue Wang , Tianfan Fu , Yinlong Xu , Zihan Ma , Hongxia Xu , Yingzhou Lu , Bang Du , Honghao Gao , Jian Wu

The vision of personalized medicine is to identify interventions that maintain or restore a person's health based on their individual biology. Medical digital twins, computational models that integrate a wide range of health-related data…

Quantitative Methods · Quantitative Biology 2025-10-21 Luis L. Fonseca , Lucas Böttcher , Borna Mehrad , Reinhard C. Laubenbacher

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

Digital twins, as precise digital representations of physical systems, have evolved from passive simulation tools into intelligent and autonomous entities through the integration of artificial intelligence technologies. This paper presents…

Smart Cities already surround us, and yet they are still incomprehensibly far from directly impacting everyday life. While current Smart Cities are often inaccessible, the experience of everyday citizens may be enhanced with a combination…

Future wireless services must be focused on improving the quality of life by enabling various applications, such as extended reality, brain-computer interaction, and healthcare. These applications have diverse performance requirements…

Networking and Internet Architecture · Computer Science 2022-02-08 Latif U. Khan , Zhu Han , Walid Saad , Ekram Hossain , Mohsen Guizani , Choong Seon Hong

We introduce Civic Digital Twin (CDT), an evolution of Urban Digital Twins designed to support a citizen-centric transformative approach to urban planning and governance. CDT is being developed in the scope of the Bologna Digital Twin…

Computers and Society · Computer Science 2024-12-10 Massimiliano Luca , Bruno Lepri , Riccardo Gallotti , Stefania Paolazzi , Mauro Bigi , Marco Pistore

The Sixth Generation (6G) network is a platform for the fusion of the physical and virtual worlds. It will integrate processing, communication, intelligence, sensing, and storage of things. All devices and their virtual counterparts will…

Computers and Society · Computer Science 2023-02-08 Ismaeel Al Ridhawi , Safa Otoum , Moayad Aloqaily

Digital twin (DT) is the recurrent and common feature in discussions about future technologies, bringing together advanced communication, computation, and artificial intelligence, to name a few. In the context of Industry 4.0, industries…

Cryptography and Security · Computer Science 2023-12-29 Kunlun Wang , Yongyi Tang , Trung Q. Duong , Saeed R. Khosravirad , Octavia A. Dobre , George K. Karagiannidis

The expansive globalization of the semiconductor supply chain has introduced numerous untrusted entities into different stages of a device's lifecycle. To make matters worse, the increase complexity in the design as well as aggressive time…

Cryptography and Security · Computer Science 2022-05-26 Hasan Al Shaikh , Mohammad Bin Monjil , Shigang Chen , Navid Asadizanjani , Farimah Farahmandi , Mark Tehranipoor , Fahim Rahman

Digital Twin technology is being envisioned to be an integral part of the industrial evolution in modern generation. With the rapid advancement in the Internet-of-Things (IoT) technology and increasing trend of automation, integration…

Robotics · Computer Science 2022-09-27 Sabur Baidya , Sumit K. Das , Mohammad Helal Uddin , Chase Kosek , Chris Summers

Network Digital Twins represent a key technology in future networks, expected to provide the capability to perform accurate analysis and predictions about the behaviour of 6G mobile networks. However, despite the availability of several…

Networking and Internet Architecture · Computer Science 2025-10-15 Cristina Emilia Costa , Tatenda Horiro Zhou , Fabrizio Granelli

Despite best efforts, various challenges remain in the creation and maintenance processes of digital twins (DTs). One of those primary challenges is the constant, continuous and omnipresent evolution of systems, their user's needs and their…

Software Engineering · Computer Science 2024-11-01 Joost Mertens , Stefan Klikovits , Francis Bordeleau , Joachim Denil , Øystein Haugen

The increasing capabilities of Digital Twins (DTs) in the context of the Internet of Things (IoT) and Industrial IoT (IIoT) call for seamless integration with simulation platforms to support system design, validation, and real-time…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-02 Marco Picone , Samuele Burattini , Marco Melloni , Prasad Talasila , Davide Ziglioli , Matteo Martinelli , Nicola Bicocchi , Alessandro Ricci , Peter Gorm Larsen

Digital Twins (DTs) are becoming popular in Additive Manufacturing (AM) due to their ability to create virtual replicas of physical components of AM machines, which helps in real-time production monitoring. Advanced techniques such as…

Computer Vision and Pattern Recognition · Computer Science 2024-11-04 Md Manjurul Ahsan , Yingtao Liu , Shivakumar Raman , Zahed Siddique

This paper presents a Digital Twin (DT) of a 6G communications system testbed that integrates two robotic manipulators with a high-precision optical infrared tracking system in Unreal Engine 5. Practical details of the setup and…

Digital twinning of vehicles is an iconic application of digital twins, as the concept of twinning dates back to the twinning of NASA space vehicles. Although digital twins (DTs) in the automotive industry have been recognized for their…

Emerging Technologies · Computer Science 2024-09-23 Robert Klar , Niklas Arvidsson , Vangelis Angelakis

The next revolution of industry will turn the industries as well as the entire society into a human-centric shape. The human presence in industrial environment and the human participation in industrial processes will be magnified more than…

Human-Computer Interaction · Computer Science 2022-11-07 Bin Han , Hans D. Schotten

Digital twin (DT) technology enables real-time simulation, prediction, and optimization of physical systems, but practical deployment faces challenges from high data requirements, proprietary data constraints, and limited adaptability to…

Datacenters are the backbone of our digital society, but raise numerous operational challenges. We envision digital twins becoming primary instruments in datacenter operations, continuously and autonomously helping with major operational…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-14 Radu Nicolae , Jules van der Toorn , Stavriana Kraniti , Houcen Liu , Alexandru Iosup