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Biomedical knowledge graphs (KGs) encode vast, heterogeneous information spanning literature, genes, pathways, drugs, diseases, and clinical trials, but leveraging them collectively for scientific discovery remains difficult. Their…

Information Retrieval · Computer Science 2026-01-21 Zifeng Wang , Zheng Chen , Ziwei Yang , Xuan Wang , Qiao Jin , Yifan Peng , Zhiyong Lu , Jimeng Sun

Knowledge Graphs (KGs) represent real-world noisy raw information in a structured form, capturing relationships between entities. However, for dynamic real-world applications such as social networks, recommender systems, computational…

Artificial Intelligence · Computer Science 2020-03-26 Amit Sheth , Swati Padhee , Amelie Gyrard

Knowledge-based biomedical data science (KBDS) involves the design and implementation of computer systems that act as if they knew about biomedicine. Such systems depend on formally represented knowledge in computer systems, often in the…

Artificial Intelligence · Computer Science 2022-09-13 Tiffany J. Callahan , Harrison Pielke-Lombardo , Ignacio J. Tripodi , Lawrence E. Hunter

Knowledge Graph Completion (KGC) aims at automatically predicting missing links for large-scale knowledge graphs. A vast number of state-of-the-art KGC techniques have got published at top conferences in several research fields, including…

Computation and Language · Computer Science 2020-07-10 Zhiqing Sun , Shikhar Vashishth , Soumya Sanyal , Partha Talukdar , Yiming Yang

Knowledge Graphs (KGs) and their machine learning counterpart, Knowledge Graph Embedding Models (KGEMs), have seen ever-increasing use in a wide variety of academic and applied settings. In particular, KGEMs are typically applied to KGs to…

Machine Learning · Computer Science 2024-12-16 Jeffrey Sardina , John D. Kelleher , Declan O'Sullivan

Biomedical networks (or graphs) are universal descriptors for systems of interacting elements, from molecular interactions and disease co-morbidity to healthcare systems and scientific knowledge. Advances in artificial intelligence,…

Machine Learning · Computer Science 2025-02-07 Michelle M. Li , Kexin Huang , Marinka Zitnik

Intelligent systems designed using machine learning algorithms require a large number of labeled data. Background knowledge provides complementary, real world factual information that can augment the limited labeled data to train a machine…

Artificial Intelligence · Computer Science 2020-05-12 Shreyansh Bhatt , Amit Sheth , Valerie Shalin , Jinjin Zhao

Knowledge graphs (KGs) have become the preferred technology for representing, sharing and adding knowledge to modern AI applications. While KGs have become a mainstream technology, the RDF/SPARQL-centric toolset for operating with them at…

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

Knowledge graph (KG) inference aims to address the natural incompleteness of KGs, including rule learning-based and KG embedding (KGE) models. However, the rule learning-based models suffer from low efficiency and generalization while KGE…

Artificial Intelligence · Computer Science 2022-08-23 Guanglin Niu , Bo Li , Yongfei Zhang , Shiliang Pu

Knowledge graphs (KG) have served as the key component of various natural language processing applications. Commonsense knowledge graphs (CKG) are a special type of KG, where entities and relations are composed of free-form text. However,…

Computation and Language · Computer Science 2023-01-04 Haodi Ma , Daisy Zhe Wang

Knowledge graphs (KGs), as structured representations of real world facts, are intelligent databases incorporating human knowledge that can help machine imitate the way of human problem solving. However, KGs are usually huge and there are…

Machine Learning · Computer Science 2023-06-27 Haotian Li , Hongri Liu , Yao Wang , Guodong Xin , Yuliang Wei

In this work, we provide a new formulation for Graph Convolutional Neural Networks (GCNNs) for link prediction on graph data that addresses common challenges for biomedical knowledge graphs (KGs). We introduce a regularized attention…

Machine Learning · Computer Science 2018-12-04 Daniel Neil , Joss Briody , Alix Lacoste , Aaron Sim , Paidi Creed , Amir Saffari

Knowledge Graph (KG) is a graph based data structure to represent facts of the world where nodes represent real world entities or abstract concept and edges represent relation between the entities. Graph as representation for knowledge has…

Social and Information Networks · Computer Science 2024-04-16 Manita Pote

We present MedSim, a novel semantic SIMilarity method based on public well-established bio-MEDical knowledge graphs (KGs) and large-scale corpus, to study the therapeutic substitution of antibiotics. Besides hierarchy and corpus of KGs,…

Computation and Language · Computer Science 2018-12-06 Kai Lei , Kaiqi Yuan , Qiang Zhang , Ying Shen

Integrating structured knowledge from Knowledge Graphs (KGs) into Large Language Models (LLMs) remains a key challenge for symbolic reasoning. Existing methods mainly rely on prompt engineering or fine-tuning, which lose structural fidelity…

Machine Learning · Computer Science 2025-05-13 Erica Coppolillo

Knowledge graph completion (KGC), the task of predicting missing information based on the existing relational data inside a knowledge graph (KG), has drawn significant attention in recent years. However, the predictive power of KGC methods…

Computation and Language · Computer Science 2023-05-26 Weihang Zhang , Ovidiu Serban , Jiahao Sun , Yi-ke Guo

In the era of Generative AI, Neurosymbolic AI is emerging as a powerful approach for tasks spanning from perception to cognition. The use of Neurosymbolic AI has been shown to achieve enhanced capabilities, including improved grounding,…

Artificial Intelligence · Computer Science 2024-11-08 Ruwan Wickramarachchi , Cory Henson , Amit Sheth

The intrinsic complexity of human biology presents ongoing challenges to scientific understanding. Researchers collaborate across disciplines to expand our knowledge of the biological interactions that define human life. AI methodologies…

Recent interest in Knowledge Base Completion (KBC) has led to a plethora of approaches based on reinforcement learning, inductive logic programming and graph embeddings. In particular, rule-based KBC has led to interpretable rules while…

Artificial Intelligence · Computer Science 2021-09-21 Prithviraj Sen , Breno W. S. R. Carvalho , Ibrahim Abdelaziz , Pavan Kapanipathi , Francois Luus , Salim Roukos , Alexander Gray