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Recent advances in automated skin cancer diagnosis have yielded performance on par with board-certified dermatologists. However, these approaches formulated skin cancer diagnosis as a simple classification task, dismissing the potential…

Image and Video Processing · Electrical Eng. & Systems 2021-12-06 Jingye Chen , Jieneng Chen , Zongwei Zhou , Bin Li , Alan Yuille , Yongyi Lu

Nuclei segmentation is the cornerstone task in histology image reading, shedding light on the underlying molecular patterns and leading to disease or cancer diagnosis. Yet, it is a laborious task that requires expertise from trained…

Image and Video Processing · Electrical Eng. & Systems 2025-11-10 Vasileios Magoulianitis , Catherine A. Alexander , Jiaxin Yang , C. -C. Jay Kuo

Accurate segmentation of tubular structures in medical images, such as vessels and airway trees, is crucial for computer-aided diagnosis, radiotherapy, and surgical planning. However, significant challenges exist in algorithm design when…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Yi Huang , Ke Zhang , Wei Liu , Yuanyuan Wang , Vishal M. Patel , Le Lu , Xu Han , Dakai Jin , Ke Yan

The emergence of deep learning techniques has advanced the image segmentation task, especially for medical images. Many neural network models have been introduced in the last decade bringing the automated segmentation accuracy close to…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Ngoc-Du Tran , Thi-Thao Tran , Quang-Huy Nguyen , Manh-Hung Vu , Van-Truong Pham

Medical image segmentation is an important step in medical image analysis, especially as a crucial prerequisite for efficient disease diagnosis and treatment. The use of deep learning for image segmentation has become a prevalent trend. The…

Image and Video Processing · Electrical Eng. & Systems 2023-08-11 Wenjian Yao , Jiajun Bai , Wei Liao , Yuheng Chen , Mengjuan Liu , Yao Xie

Separating overlapped nuclei is a major challenge in histopathology image analysis. Recently published approaches have achieved promising overall performance on nuclei segmentation; however, their performance on separating overlapped nuclei…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Haotian Wang , Aleksandar Vakanski , Changfa Shi , Min Xian

Precise and scalable instance segmentation of cell nuclei is essential for computational pathology, yet gigapixel Whole-Slide Images pose major computational challenges. Existing approaches rely on patch-based processing and costly…

Computer Vision and Pattern Recognition · Computer Science 2026-01-07 Matěj Pekár , Vít Musil , Rudolf Nenutil , Petr Holub , Tomáš Brázdil

Identify the cells' nuclei is the important point for most medical analyses. To assist doctors finding the accurate cell' nuclei location automatically is highly demanded in the clinical practice. Recently, fully convolutional neural…

Computer Vision and Pattern Recognition · Computer Science 2019-11-25 Tianyang Zhang , Rui Ma

Medical image segmentation plays a vital role in various clinical applications, enabling accurate delineation and analysis of anatomical structures or pathological regions. Traditional CNNs have achieved remarkable success in this field.…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Seyed M. R. Modaresi , Aomar Osmani , Mohammadreza Razzazi , Abdelghani Chibani

Nuclei detection and segmentation in hematoxylin and eosin-stained (H&E) tissue images are important clinical tasks and crucial for a wide range of applications. However, it is a challenging task due to nuclei variances in staining and…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Fabian Hörst , Moritz Rempe , Lukas Heine , Constantin Seibold , Julius Keyl , Giulia Baldini , Selma Ugurel , Jens Siveke , Barbara Grünwald , Jan Egger , Jens Kleesiek

Quantitative analysis of cell nuclei in microscopic images is an essential yet challenging source of biological and pathological information. The major challenge is accurate detection and segmentation of densely packed nuclei in images…

Quantitative Methods · Quantitative Biology 2019-11-14 Linqing Feng , Jun Ho Song , Jiwon Kim , Soomin Jeong , Jin Sung Park , Jinhyun Kim

Domain-generalized nuclei segmentation refers to the generalizability of models to unseen domains based on knowledge learned from source domains and is challenged by various image conditions, cell types, and stain strategies. Recently, the…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Zhenye Lou , Qing Xu , Zekun Jiang , Xiangjian He , Zhen Chen , Yi Wang , Chenxin Li , Maggie M. He , Wenting Duan

Automated medical image segmentation is becoming increasingly crucial to modern clinical practice, driven by the growing demand for precise diagnosis, the push towards personalized treatment plans, and the advancements in machine learning…

Image and Video Processing · Electrical Eng. & Systems 2023-11-13 Tan-Hanh Pham , Xianqi Li , Kim-Doang Nguyen

The field of computational pathology has witnessed great advancements since deep neural networks have been widely applied. These networks usually require large numbers of annotated data to train vast parameters. However, it takes…

Computer Vision and Pattern Recognition · Computer Science 2022-08-11 Yixiao Zhang , Adam Kortylewski , Qing Liu , Seyoun Park , Benjamin Green , Elizabeth Engle , Guillermo Almodovar , Ryan Walk , Sigfredo Soto-Diaz , Janis Taube , Alex Szalay , Alan Yuille

Separating overlapped nuclei is a major challenge in histopathology image analysis. Recently published approaches have achieved promising overall performance on public datasets; however, their performance in segmenting overlapped nuclei are…

Image and Video Processing · Electrical Eng. & Systems 2020-02-05 Haotian Wang , Min Xian , Aleksandar Vakanski

In the past few years, convolutional neural networks (CNNs), particularly U-Net, have been the prevailing technique in the medical image processing era. Specifically, the seminal U-Net, as well as its alternatives, have successfully managed…

Computer Vision and Pattern Recognition · Computer Science 2022-07-28 Reza Azad , Mohammad T. AL-Antary , Moein Heidari , Dorit Merhof

Since their emergence, Convolutional Neural Networks (CNNs) have made significant strides in medical image analysis. However, the local nature of the convolution operator may pose a limitation for capturing global and long-range…

Image and Video Processing · Electrical Eng. & Systems 2024-04-01 Abdul Rehman Khan , Asifullah Khan

While CNN-based methods have been the cornerstone of medical image segmentation due to their promising performance and robustness, they suffer from limitations in capturing long-range dependencies. Transformer-based approaches are currently…

Computer Vision and Pattern Recognition · Computer Science 2023-01-27 Reza Azad , Yiwei Jia , Ehsan Khodapanah Aghdam , Julien Cohen-Adad , Dorit Merhof

Biomedical image segmentation is crucial for accurately diagnosing and analyzing various diseases. However, Convolutional Neural Networks (CNNs) and Transformers, the most commonly used architectures for this task, struggle to effectively…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Rong Zhou , Zhengqing Yuan , Zhiling Yan , Weixiang Sun , Kai Zhang , Yiwei Li , Yanfang Ye , Xiang Li , Lifang He , Lichao Sun

Purpose: Automatic and accurate segmentation of fundus vessel images has become an essential prerequisite for computer-aided diagnosis of ophthalmic diseases such as diabetes mellitus. The task of high-precision retinal vessel segmentation…

Image and Video Processing · Electrical Eng. & Systems 2024-11-06 Xiang Li , Mingsi Liu , Lixin Duan