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Magnetic Resonance Imaging (MRI) plays a pivotal role in the early diagnosis and monitoring of Alzheimer's disease (AD). However, the subtle structural variations in brain MRI scans often pose challenges for conventional deep learning…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Faisal Ahmed

Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain…

Image and Video Processing · Electrical Eng. & Systems 2020-04-07 Sheng Liu , Chhavi Yadav , Carlos Fernandez-Granda , Narges Razavian

Deep learning has become an important tool for Alzheimer's disease (AD) classification from structural MRI. Many existing studies analyze individual 2D slices extracted from MRI volumes, while clinical neuroimaging practice typically relies…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Md Sifat , Sania Akter , Akif Islam , Md. Ekramul Hamid , Abu Saleh Musa Miah , Najmul Hassan , Md Abdur Rahim , Jungpil Shin

Alzheimer's disease (AD) is a progressive neurological disorder, meaning that the symptoms develop gradually throughout the years. It is also the main cause of dementia, which affects memory, thinking skills, and mental abilities. Nowadays,…

Computation and Language · Computer Science 2022-11-09 Loukas Ilias , Dimitris Askounis , John Psarras

Edge-based multimodal medical monitoring requires models that balance diagnostic accuracy with severe energy constraints. Continuous acquisition of ECG, PPG, EMG, and IMU streams rapidly drains wearable batteries, often limiting operation…

Emerging Technologies · Computer Science 2026-04-14 Chengwei Zhou , Zhaoyan Jia , Haotian Yu , Xuming Chen , Brandon Lee , Christopher Pulliam , Steve Majerus , Massoud Pedram , Gourav Datta

Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot…

Machine Learning · Computer Science 2019-03-25 Jack Albright

Multimodal MRI is essential for brain tumor segmentation, yet missing modalities in clinical practice cause existing methods to exhibit >40% performance variance across modality combinations, rendering them clinically unreliable. We propose…

Image and Video Processing · Electrical Eng. & Systems 2026-01-28 Chengxiang Guo , Jian Wang , Junhua Fei , Xiao Li , Chunling Chen , Yun Jin

Multimodal neuroimaging provides complementary insights for Alzheimer's disease diagnosis, yet clinical datasets frequently suffer from missing modalities. We propose ACADiff, a framework that synthesizes missing brain imaging modalities…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Rong Zhou , Houliang Zhou , Yao Su , Brian Y. Chen , Yu Zhang , Lifang He , Alzheimer's Disease Neuroimaging Initiative

Classifying 3D MRI images for early detection of Alzheimer's disease is a critical task in medical imaging. Traditional approaches using Convolutional Neural Networks (CNNs) and Transformers face significant challenges in this domain. CNNs,…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Muthukumar K A , Amit Gurung , Priya Ranjan

Dementia is a progressive cognitive syndrome with Alzheimer's disease (AD) as the leading cause. Conversation-based AD detection offers a cost-effective alternative to clinical methods, as language dysfunction is an early biomarker of AD.…

Computation and Language · Computer Science 2025-02-27 Arezo Shakeri , Mina Farmanbar , Krisztian Balog

Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that…

Machine Learning · Statistics 2017-08-16 Lev E. Givon , Laura J. Mariano , David O'Dowd , John M. Irvine , Abraham R. Schneider

Alzheimer's Disease (AD) is the most common type of dementia. In all leading countries, it is one of the primary reasons of death in senior citizens. Currently, it is diagnosed by calculating the MSME score and by the manual study of MRI…

Machine Learning · Computer Science 2019-12-11 Rishu Garg , Rekh Ram Janghel , Yogesh Rathore

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely impairs cognitive function and quality of life. Timely intervention in AD relies heavily on early and precise diagnosis, which remains challenging due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xiaoxiao Yang , Meiliang Liu , Yunfang Xu , Zijin Li , Zhengye Si , Xinyue Yang , Zhiwen Zhao

We propose an interpretable 3D Grid-Attention deep neural network that can accurately predict a person's age and whether they have Alzheimer's disease (AD) from a structural brain MRI scan. Building on a 3D convolutional neural network, we…

Tissues and Organs · Quantitative Biology 2020-11-19 Pradeep Lam , Alyssa H. Zhu , Iyad Ba Gari , Neda Jahanshad , Paul M. Thompson

Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

Machine Learning · Computer Science 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

Deep learning approaches, together with neuroimaging techniques, play an important role in psychiatric disorders classification. Previous studies on psychiatric disorders diagnosis mainly focus on using functional connectivity matrices of…

Image and Video Processing · Electrical Eng. & Systems 2023-10-05 Guoxin Wang , Xuyang Cao , Shan An , Fengmei Fan , Chao Zhang , Jinsong Wang , Feng Yu , Zhiren Wang

Mild cognitive impairment(MCI) is a precursor of Alzheimer's disease(AD), and the detection of MCI is of great clinical significance. Analyzing the structural brain networks of patients is vital for the recognition of MCI. However, the…

Neurons and Cognition · Quantitative Biology 2022-08-19 Heng Kong , Shuqiang Wang

Neuroimaging of large populations is valuable to identify factors that promote or resist brain disease, and to assist diagnosis, subtyping, and prognosis. Data-driven models such as convolutional neural networks (CNNs) have increasingly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-16 Nikhil J. Dhinagar , Sophia I. Thomopoulos , Emily Laltoo , Paul M. Thompson

This proof-of-concept study introduces a novel multimodal framework combining synchronized EEG-fNIRS modalities with neuronal avalanche analysis to identify early network dysfunction in Alzheimer's disease. The approach leverages…

Neurons and Cognition · Quantitative Biology 2026-03-25 Eva Guttmann-Flury , Yun-Hsuan Chen , Qiaoyuan Xiang , Hao Zhang , Mohamad Sawan

Deep learning methods based on Convolutional Neural Networks (CNNs) have shown great potential to improve early and accurate diagnosis of Alzheimer's disease (AD) dementia based on imaging data. However, these methods have yet to be widely…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Wenjie Kang , Lize Jiskoot , Peter De Deyn , Geert Biessels , Huiberdina Koek , Jurgen Claassen , Huub Middelkoop , Wiesje Flier , Willemijn J. Jansen , Stefan Klein , Esther Bron