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We propose a novel type of minor-embedding (ME) in simulated-annealing-based Ising machines. The Ising machines can solve combinatorial optimization problems. Many combinatorial optimization problems are mapped to find the ground…

Statistical Mechanics · Physics 2020-12-07 Tatsuhiko Shirai , Shu Tanaka , Nozomu Togawa

Quantum annealing is a heuristic algorithm for searching the ground state of an Ising model. Heuristic algorithms aim to obtain near-optimal solutions with a reasonable computation time. Accordingly, many algorithms have so far been…

Quantum Physics · Physics 2022-11-09 Shuntaro Okada , Masayuki Ohzeki

We introduce a physics-inspired continuous relaxation framework that yields substantially improved solutions for NP-hard combinatorial optimization problems, including Quadratic Unconstrained Binary Optimization (QUBO), binary sparse…

Statistical Mechanics · Physics 2026-05-26 Khen Cohen , Mark Glass , Meir Feder , Yaron Oz

In VLSI physical design, many algorithms require the solution of difficult combinatorial optimization problems such as max/min-cut, max-flow problems etc. Due to the vast number of elements typically found in this problem domain, these…

Computational Physics · Physics 2019-03-18 Chase Cook , Hengyang Zhao , Takashi Sato , Masayuki Hiromoto , Sheldon X. -D. Tan

In the field of quantum computing, combinatorial optimization problems are typically addressed using QUBO (Quadratic Unconstrained Binary Optimization) solvers. However, these solvers are often insufficient for tackling higher-order…

Quantum Physics · Physics 2024-07-24 Yuichiro Minato

Diagnosing the minimal set of faults capable of explaining a set of given observations, e.g., from sensor readouts, is a hard combinatorial optimization problem usually tackled with artificial intelligence techniques. We present the mapping…

Quadratic Unconstrained Binary Optimization (QUBO) is a generic technique to model various NP-hard Combinatorial Optimization problems (CO) in the form of binary variables. Ising Hamiltonian is used to model the energy function of a system.…

Machine Learning · Computer Science 2023-12-13 Redwan Ahmed Rizvee , Raheeb Hassan , Md. Mosaddek Khan

As we approach the physical limits predicted by Moore's law, a variety of specialized hardware is emerging to tackle specialized tasks in different domains. Within combinatorial optimization, adiabatic quantum computers, CMOS annealers, and…

Data Structures and Algorithms · Computer Science 2020-12-01 Xiaoyuan Liu , Hayato Ushijima-Mwesigwa , Avradip Mandal , Sarvagya Upadhyay , Ilya Safro , Arnab Roy

Motivated by near term quantum computing hardware limitations, combinatorial optimization problems that can be addressed by current quantum algorithms and noisy hardware with little or no overhead are used to probe capabilities of quantum…

Optimization and Control · Mathematics 2026-05-15 Elijah Pelofske , Andreas Bärtschi , Stephan Eidenbenz

The Operational Fixed Interval Scheduling Problem aims to find an assignment of jobs to machines that maximizes the total weight of the completed jobs. We introduce a new variant of the problem where we consider the additional goal of…

Emerging Technologies · Computer Science 2023-10-24 Ludmila Botelho , Özlem Salehi

The peptide-protein docking problem is an important problem in structural biology that facilitates rational and efficient drug design. In this work, we explore modeling and solving this problem with the quantum-amenable quadratic…

Recent advances in quantum computing and the increasing availability of quantum hardware have substantially enhanced the practical relevance of quantum approaches to discrete optimization. Among these, the Quadratic Unconstrained Binary…

Quantum Physics · Physics 2026-02-12 Felix P. Broesamle , Stefan Nickel

In recent years, there is a growing interest in using quantum computers for solving combinatorial optimization problems. In this work, we developed a generic, machine learning-based framework for mapping continuous-space inverse design…

Quadratic Unconstrained Binary Optimization (QUBO) is a broad class of optimization problems with many practical applications. To solve its hard instances in an exact way, known classical algorithms require exponential time and several…

Quantum Physics · Physics 2021-01-21 Gian Giacomo Guerreschi

Quadratic Unconstrained Binary Optimization (QUBO) provides a versatile framework for representing NP-hard combinatorial problems, yet existing solvers often face trade-offs among speed, accuracy, and scalability. In this work, we introduce…

Quantum Physics · Physics 2025-06-06 Jiecheng Yang , Ding Wang , Xiang Zhao , Hairui Zhang , Ming Gao , Lin Yang

Ising Machine is a promising computing approach for solving combinatorial optimization problems. It is naturally suited for energy-saving and compact in-memory computing implementations with emerging memories. A na\"ive in-memory computing…

Hardware Architecture · Computer Science 2024-01-30 George Higgins Hutchinson , Ethan Sifferman , Tinish Bhattacharya , Dmitri B. Strukov

Quantum Annealing (QA) can efficiently solve combinatorial optimization problems whose objective functions are represented by Quadratic Unconstrained Binary Optimization (QUBO) formulations. For broader applicability of QA, quadratization…

Quantum Physics · Physics 2025-07-29 Hyakka Nakada , Shu Tanaka

The Travelling Salesman Problem (TSP) is an important combinatorial optimisation problem, and is usually solved on a quantum computer using a Quadratic Unconstrained Binary Optimisation (QUBO) formulation or a Higher Order Binary…

Quantum Physics · Physics 2024-06-21 Daniel Goldsmith , Joe Day-Evans

Verification of binary neural network (BNN) robustness is NP-hard, as it can be formulated as a combinatorial search for an adversarial perturbation that induces misclassification. Exact verification methods therefore scale poorly with…

Emerging Technologies · Computer Science 2026-03-09 Madhav Vadlamani , Rahul Singh , Yuyao Kong , Zheng Zhang , Shimeng Yu

The increasing complexity of industrial scheduling and transport routing problems motivates the study of alternative optimization formulations and computational paradigms. In this work, we study how higher-order unconstrained binary…