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Digital Twins hold great potential to personalize clinical patient care, provided the concept is translated to meet specific requirements emerging from established clinical workflows. We present a general and unspecialized Digital Twin…

Chronic diseases constitute the principal burden of morbidity, mortality, and healthcare costs worldwide, yet current health systems remain fragmented and predominantly reactive. Patient Medical Digital Twins (PMDTs) offer a paradigm shift:…

Software Engineering · Computer Science 2026-02-13 Micheal P. Papazoglou , Bernd J. Krämer , Mira Raheem , Amal Elgammal

Emerging from NASA's spacecraft simulations in the 1960s, digital twin technology has advanced through industrial adoption to spark a healthcare transformation. A digital twin is a dynamic, data-driven virtual counterpart of a physical…

Artificial Intelligence · Computer Science 2025-11-27 Yunqi Zhang , Kuangyu Shi , Biao Li

A patient's digital twin is a computational model that describes the evolution of their health over time. Digital twins have the potential to revolutionize medicine by enabling individual-level computer simulations of human health, which…

Artificial Intelligence (AI) and Large Language Models (LLMs) hold significant promise in revolutionizing healthcare, especially in clinical applications. Simultaneously, Digital Twin technology, which models and simulates complex systems,…

Artificial Intelligence · Computer Science 2024-09-27 Himanshu Pandey , Akhil Amod , Shivang , Kshitij Jaggi , Ruchi Garg , Abheet Jain , Vinayak Tantia

A digital health twin can be defined as a virtual model of a physical person, in this specific case, a patient. This virtual model is constituted by multidimensional data that can host from clinical, molecular and therapeutic parameters to…

Computers and Society · Computer Science 2022-12-02 Manuel Cossio

We propose a digital twin approach to improve healthcare decision support systems with a combination of domain knowledge and data. Domain knowledge helps build decision thresholds that doctors can use to determine a risk or recommend a…

Artificial Intelligence · Computer Science 2019-10-31 Dattaraj Jagdish Rao , Shraddha Mane

Digital twins (DT) are increasingly used in healthcare to model patients, processes, and physiological systems. While recent solutions leverage visualization, visual analytics, and user interaction, these systems rarely incorporate…

Human-Computer Interaction · Computer Science 2025-09-09 Mariia Ershova , Graziano Blasilli

Digital twins (DTs) are redefining healthcare by paving the way for more personalized, proactive, and intelligent medical interventions. As the shift toward personalized care intensifies, there is a growing need for an individual's virtual…

Human-Computer Interaction · Computer Science 2025-03-18 Melvin Mokhtari

Digital twins are emerging as a valuable tool for short-term decision-making as well as for long-term strategic planning across numerous domains, including process industry, energy, space, transport, and healthcare. This paper reports on…

Artificial Intelligence · Computer Science 2025-05-13 Riccardo Sieve , Paul Kobialka , Laura Slaughter , Rudolf Schlatte , Einar Broch Johnsen , Silvia Lizeth Tapia Tarifa

Digital Twin (DT) technology has emerged as a transformative approach in healthcare, but its application in personalized patient care remains limited. This paper aims to present a practical implementation of DT in the management of chronic…

Quantitative Methods · Quantitative Biology 2025-07-17 Javad M Alizadeh , Mukesh K Patel , Huanmei Wu

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

The growing complexity of healthcare systems requires advanced computational models for real-time monitoring, secure data exchange, and intelligent decision-making. Digital Twins (DTs) provide virtual representations of physical healthcare…

Emerging Technologies · Computer Science 2026-02-18 Asma Taheri Monfared , Andrea Bombarda , Angelo Gargantini , Majid Haghparast

With rapid digitization and digitalization, drawing a fine line between the digital and the physical world has become nearly impossible. It has become essential more than ever to integrate all spheres of life into a single Digital Thread to…

Personalized chronic care requires the integration of multimodal health data to enable precise, adaptive, and preventive decision-making. Yet most current digital twin (DT) applications remain organ-specific or tied to isolated data types,…

Software Engineering · Computer Science 2025-10-13 Amal Elgammal , Bernd J. Krämer , Michael P. Papazoglou , Mira Raheem

As the population grows, the need for a quality level of medical services grows correspondingly, so does the demand for information technology in medicine. The concept of "Smart Healthcare" offers many approaches aimed at solving the acute…

Computers and Society · Computer Science 2021-06-23 Ivan Volkov , Gleb Radchenko , Andrey Tchernykh

Human digital twins (HDTs) are dynamic, data-driven virtual representations of individuals, continuously updated with multimodal data to simulate, monitor, and predict health trajectories. By integrating clinical, physiological, behavioral,…

Human-Computer Interaction · Computer Science 2025-08-19 Rong Pan , Hongyue Sun , Xiaoyu Chen , Giulia Pedrielli , Jiapeng Huang

Medical imaging has played a pivotal role in advancing and refining digital twin technology, allowing for the development of highly personalized virtual models that represent human anatomy and physiological functions. A key component in…

Medical Physics · Physics 2024-11-14 Feng Zhao , Yizhou Wu , Mingzhe Hu , Chih-Wei Chang , Ruirui Liu , Richard Qiu , Xiaofeng Yang

The adoption of digital twins (DTs) in precision medicine is increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. However, the reliance…

Virtual patients and digital patients/twins are two similar concepts gaining increasing attention in health care with goals to accelerate drug development and improve patients' survival, but with their own limitations. Although methods have…

Other Quantitative Biology · Quantitative Biology 2024-06-25 Hanwen Wang , Theinmozhi Arulraj , Alberto Ippolito , Aleksander S. Popel
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