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Protein sequence alignment is a cornerstone of bioinformatics, traditionally approached using dynamic programming (DP) algorithms that find an optimal sequential path. This paper introduces UniOTalign, a novel framework that recasts…

Quantitative Methods · Quantitative Biology 2025-10-09 Yue Hu , Zanxia Cao , Yingchao Liu

We generalize Grover's unstructured quantum search algorithm to enable it to use an arbitrary starting superposition and an arbitrary unitary matrix simultaneously. We derive an exact formula for the probability of the generalized Grover's…

Quantum Physics · Physics 2008-12-18 Robert Gingrich , Colin P. Williams , Nicolas Cerf

Graph matching is a commonly used technique in computer vision and pattern recognition. Recent data-driven approaches have improved the graph matching accuracy remarkably, whereas some traditional algorithm-based methods are more robust to…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Haoru Tan , Chuang Wang , Sitong Wu , Xu-Yao Zhang , Fei Yin , Cheng-Lin Liu

We consider a novel approach of measuring the homology of DNA sequences based of the variety of optimal alignments in the longest common subsequence sense. The proposed approach is compared with BLAST in measuring the homology of four…

Applications · Statistics 2012-10-16 Erik Hirmo , Jüri Lember , Heinrich Matzinger

Mutual correlation between segments of DNA or protein sequences can be detected by Smith-Waterman local alignments. We present a statistical analysis of alignment of such sequences, based on a recent scaling theory. A new fidelity measure…

Condensed Matter · Physics 2007-05-23 Rolf Olsen , Terence Hwa , Michael Lassig

This paper describes a method to efficiently retrieve protein database sequences similar to a query sequence, while allowing for significant numbers of mutations. We call this method SEQR for SEQuence Retrieval. This approach increases the…

Genomics · Quantitative Biology 2018-11-05 David I. Hurwitz , Lianyi Han , Lewis Y. Geer

A critical step of genome sequence analysis is the mapping of sequenced DNA fragments (i.e., reads) collected from an individual to a known linear reference genome sequence (i.e., sequence-to-sequence mapping). Recent works replace the…

In a fundamental paper [Phys. Rev. Lett. 78, 325 (1997)] Grover showed how a quantum computer can find a single marked object in a database of size N by using only O(N^{1/2}) queries of the oracle that identifies the object. His result was…

Quantum Physics · Physics 2009-11-11 Shahar Dolev , Itamar Pitowsky , Boaz Tamir

Cardinality-constrained binary optimization is a fundamental computational primitive with broad applications in machine learning, finance, and scientific computing. In this work, we introduce a Grover-based quantum algorithm that exploits…

Quantum Physics · Physics 2026-03-17 Haomu Yuan , Hanqing Wu , Kuan-Cheng Chen , Bin Cheng , Crispin H. W. Barnes

We propose a quantum string comparison method whose main building blocks are a specially designed oracle construction followed by Grover's search algorithm. The purpose of the oracle is to compare all alphabets of the string in parallel.…

Quantum Physics · Physics 2020-05-20 Vikram Menon , Ayan Chattopadhyay

We study the problem of learning an unknown graph provided via an oracle using a quantum algorithm. We consider three query models. In the first model ("OR queries"), the oracle returns whether a given subset of the vertices contains any…

Quantum Physics · Physics 2021-01-26 Ashley Montanaro , Changpeng Shao

One specific subset of quantum algorithms is Grovers Ordered Search Problem (OSP), the quantum counterpart of the classical binary search algorithm, which utilizes oracle functions to produce a specified value within an ordered database.…

Quantum Physics · Physics 2017-01-24 Jupinder Parmar , Saarim Rahman , Jesse Thiara

As a fundamental problem in pattern recognition, graph matching has applications in a variety of fields, from computer vision to computational biology. In graph matching, patterns are modeled as graphs and pattern recognition amounts to…

Computer Vision and Pattern Recognition · Computer Science 2008-06-19 Tiberio S. Caetano , Julian J. McAuley , Li Cheng , Quoc V. Le , Alex J. Smola

Chaining algorithms aim to form a semi-global alignment of two sequences based on a set of anchoring local alignments as input. Depending on the optimization criteria and the exact definition of a chain, there are several $O(n \log n)$ time…

Data Structures and Algorithms · Computer Science 2020-04-27 Veli Mäkinen , Kristoffer Sahlin

We provide a new quantum algorithm that efficiently determines the quality of a least-squares fit over an exponentially large data set by building upon an algorithm for solving systems of linear equations efficiently (Harrow et al., Phys.…

Quantum Physics · Physics 2013-01-10 Nathan Wiebe , Daniel Braun , Seth Lloyd

We solve the unstructured search problem in constant time by computing with a physically motivated nonlinearity of the Gross-Pitaevskii type. This speedup comes, however, at the novel expense of increasing the time-measurement precision.…

Quantum Physics · Physics 2013-06-14 David A. Meyer , Thomas G. Wong

This work proposes a computational procedure that uses a quantum walk in a complete graph to train classical artificial neural networks. The idea is to apply the quantum walk to search the weight set values. However, it is necessary to…

Quantum Physics · Physics 2021-09-09 Luciano S. de Souza , Jonathan H. A. de Carvalho , Tiago A. E. Ferreira

Quantum computers and quantum algorithms have made great strides in the last few years and promise improvements over classical computing for specific tasks. Although the current hardware is not yet ready to make real impacts at the time of…

Quantum Physics · Physics 2024-08-28 Nils Quetschlich , Tobias Forster , Adrian Osterwind , Domenik Helms , Robert Wille

Multiple sequence alignment (MSA) is a core operation for comparing genome sequences and is widely used in bio-informatics. MAFFT, a practical MSA tool, repeatedly shifts a pair of sequences and computes a distance. Because the number of…

Quantum Physics · Physics 2026-03-02 Yusuke Kimura , Yutaka Takita

We give an algorithm for prediction on a quantum computer which is based on a linear regression model with least squares optimisation. Opposed to related previous contributions suffering from the problem of reading out the optimal…

Quantum Physics · Physics 2016-09-07 Maria Schuld , Ilya Sinayskiy , Francesco Petruccione
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