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Objectives: to propose a fully-automatic computer-aided diagnosis (CAD) solution for liver lesion characterization, with uncertainty estimation. Methods: we enrolled 400 patients who had either liver resection or a biopsy and was diagnosed…

Image and Video Processing · Electrical Eng. & Systems 2021-10-19 Peng Wang , Yuhsuan Wu , Bolin Lai , Xiao-Yun Zhou , Le Lu , Wendi Liu , Huabang Zhou , Lingyun Huang , Jing Xiao , Adam P. Harrison , Ningyang Jia , Heping Hu

Active learning is a unique abstraction of machine learning techniques where the model/algorithm could guide users for annotation of a set of data points that would be beneficial to the model, unlike passive machine learning. The primary…

Computer Vision and Pattern Recognition · Computer Science 2021-01-08 Vishwesh Nath , Dong Yang , Bennett A. Landman , Daguang Xu , Holger R. Roth

Organ segmentation in CT volumes is an important pre-processing step in many computer assisted intervention and diagnosis methods. In recent years, convolutional neural networks have dominated the state of the art in this task. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-08-25 Roger D. Soberanis-Mukul , Nassir Navab , Shadi Albarqouni

Neural Networks have high accuracy in solving problems where it is difficult to detect patterns or create a logical model. However, these algorithms sometimes return wrong solutions, which become problematic in high-risk domains like…

Machine Learning · Computer Science 2025-06-26 Miguel N. Font , José L. Jorro-Aragoneses , Carlos M. Alaíz

Semi-supervised learning has made significant strides in the medical domain since it alleviates the heavy burden of collecting abundant pixel-wise annotated data for semantic segmentation tasks. Existing semi-supervised approaches enhance…

Computer Vision and Pattern Recognition · Computer Science 2021-12-03 Xu Zheng , Chong Fu , Haoyu Xie , Jialei Chen , Xingwei Wang , Chiu-Wing Sham

Deep learning methods for unsupervised registration often rely on objectives that assume a uniform noise level across the spatial domain (e.g. mean-squared error loss), but noise distributions are often heteroscedastic and input-dependent…

Image and Video Processing · Electrical Eng. & Systems 2024-07-19 Xiaoran Zhang , Daniel H. Pak , Shawn S. Ahn , Xiaoxiao Li , Chenyu You , Lawrence H. Staib , Albert J. Sinusas , Alex Wong , James S. Duncan

This work studies lung tumor growth prediction from sparse and irregular longitudinal computed tomography (CT) observations with measurement variability. A Bayesian physics-informed neural network is developed by combining Gompertz growth…

Machine Learning · Computer Science 2026-05-14 Lingfei Kong , Haoran Ma

Uncertainty in medical image segmentation is inherently non-uniform, with boundary regions exhibiting substantially higher ambiguity than interior areas. Conventional training treats all pixels equally, leading to unstable optimization…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Jinming Zhang , Youpeng Yang , Xi Yang , Haosen Shi , Yuyao Yan , Qiufeng Wang , Guangliang Cheng , Kaizhu Huang

Recent evolution in deep learning has proven its value for CT-based lung nodule classification. Most current techniques are intrinsically black-box systems, suffering from two generalizability issues in clinical practice. First,…

Image and Video Processing · Electrical Eng. & Systems 2022-02-28 Hanxiao Zhang , Liang Chen , Xiao Gu , Minghui Zhang , Yulei Qin , Feng Yao , Zhexin Wang , Yun Gu , Guang-Zhong Yang

Deep neural networks are increasingly being used for the analysis of medical images. However, most works neglect the uncertainty in the model's prediction. We propose an uncertainty-aware deep kernel learning model which permits the…

Machine Learning · Computer Science 2021-06-11 Zhiliang Wu , Yinchong Yang , Jindong Gu , Volker Tresp

Liver cirrhosis is an insidious condition involving the substitution of normal liver tissue with fibrous scar tissue and causing major health complications. The conventional method of diagnosis using liver biopsy is invasive and, therefore,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Kapil Kashyap , Sean Fargose , Chrisil Dabre , Fatema Dolaria , Nilesh Patil , Aniket Kore

Training deep convolutional neural networks usually requires a large amount of labeled data. However, it is expensive and time-consuming to annotate data for medical image segmentation tasks. In this paper, we present a novel…

Computer Vision and Pattern Recognition · Computer Science 2019-07-17 Lequan Yu , Shujun Wang , Xiaomeng Li , Chi-Wing Fu , Pheng-Ann Heng

Purpose: To propose and evaluate an accelerated $T_{1\rho}$ quantification method that combines $T_{1\rho}$-weighted fast spin echo (FSE) images and proton density (PD)-weighted anatomical FSE images, leveraging deep learning models for…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Junru Zhong , Chaoxing Huang , Ziqiang Yu , Fan Xiao , Siyue Li , Tim-Yun Michael Ong , Ki-Wai Kevin Ho , Queenie Chan , James F. Griffith , Weitian Chen

Deep learning approaches often require huge datasets to achieve good generalization. This complicates its use in tasks like image-based medical diagnosis, where the small training datasets are usually insufficient to learn appropriate data…

Computer Vision and Pattern Recognition · Computer Science 2021-02-12 Roberto Vega , Pouneh Gorji , Zichen Zhang , Xuebin Qin , Abhilash Rakkunedeth Hareendranathan , Jeevesh Kapur , Jacob L. Jaremko , Russell Greiner

Image-to-image translation plays a vital role in tackling various medical imaging tasks such as attenuation correction, motion correction, undersampled reconstruction, and denoising. Generative adversarial networks have been shown to…

Computer Vision and Pattern Recognition · Computer Science 2021-07-05 Uddeshya Upadhyay , Yanbei Chen , Tobias Hepp , Sergios Gatidis , Zeynep Akata

Accurate classification of computed tomography (CT) images is essential for diagnosis and treatment planning, but existing methods often struggle with the subtle and spatially diverse nature of pathological features. Current approaches…

Image and Video Processing · Electrical Eng. & Systems 2025-07-21 Shravan Venkatraman , Pavan Kumar S , Rakesh Raj Madavan , Chandrakala S

Recent works have shown that deep neural networks can achieve super-human performance in a wide range of image classification tasks in the medical imaging domain. However, these works have primarily focused on classification accuracy,…

Computer Vision and Pattern Recognition · Computer Science 2020-09-10 Gongbo Liang , Yu Zhang , Xiaoqin Wang , Nathan Jacobs

Non-invasive radiological-based lesion characterization and identification, e.g., to differentiate cancer subtypes, has long been a major aim to enhance oncological diagnosis and treatment procedures. Here we study a specific population of…

Computer Vision and Pattern Recognition · Computer Science 2020-09-01 Yuankai Huo , Jinzheng Cai , Chi-Tung Cheng , Ashwin Raju , Ke Yan , Bennett A. Landman , Jing Xiao , Le Lu , Chien-Hung Liao , Adam P. Harrison

We present a framework for learning of modeling uncertainties in Linear Time Invariant (LTI) systems. We propose a methodology to extend the dynamics of an LTI (without uncertainty) with an uncertainty model, based on measured data, to…

Systems and Control · Electrical Eng. & Systems 2023-11-01 Farhad Ghanipoor , Carlos Murguia , Peyman Mohajerin Esfahani , Nathan van de Wouw

We introduce a method for fast estimation of data-adapted, spatio-temporally dependent regularization parameter-maps for variational image reconstruction, focusing on total variation (TV)-minimization. Our approach is inspired by recent…