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Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued and compulsive use of opioids despite harmful consequences. The development of medications with improved efficacy and safety profiles for OUD…

Biomolecules · Quantitative Biology 2023-03-02 Hongsong Feng , Jian Jiang , Guo-Wei Wei

The opioid overdose epidemic remains a critical public health crisis, particularly in the United States, leading to significant mortality and societal costs. Social media platforms like Reddit provide vast amounts of unstructured data that…

Computation and Language · Computer Science 2025-08-13 Muhammad Ahmad , Rita Orji , Fida Ullah , Ildar Batyrshin , Grigori Sidorov

The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical…

Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved…

Biomolecules · Quantitative Biology 2023-01-13 Hongsong Feng , Rana Elladki , Jian Jiang , Guo-Wei Wei

Labeled data is a fundamental component in training supervised deep learning models for computer vision tasks. However, the labeling process, especially for ordinal image classification where class boundaries are often ambiguous, is prone…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Alireza Sedighi Moghaddam , Mohammad Reza Mohammadi

In recent years the importance of Smart Healthcare cannot be overstated. The current work proposed to expand the state-of-art of smart healthcare in integrating solutions for Obsessive Compulsive Disorder (OCD). Identification of OCD from…

Background: Alzheimer's disease and related dementias (ADRD) are progressive neurodegenerative conditions where early detection is vital for timely intervention and care. Spontaneous speech contains rich acoustic and linguistic markers that…

Computation and Language · Computer Science 2025-06-16 Jingyu Li , Lingchao Mao , Hairong Wang , Zhendong Wang , Xi Mao , Xuelei Sherry Ni

Since the strong comorbid similarity in NDDs, such as attention-deficit hyperactivity disorder, can interfere with the accurate diagnosis of autism spectrum disorder (ASD), identifying unknown classes is extremely crucial and challenging…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Jiaming Yu , Zihao Guan , Xinyue Chang , Shujie Liu , Zhenshan Shi , Xiumei Liu , Changcai Yang , Riqing Chen , Lanyan Xue , Lifang Wei

AI-aided drug discovery (AIDD) is gaining increasing popularity due to its promise of making the search for new pharmaceuticals quicker, cheaper and more efficient. In spite of its extensive use in many fields, such as ADMET prediction,…

Reading comprehension is one of the crucial tasks for furthering research in natural language understanding. A lot of diverse reading comprehension datasets have recently been introduced to study various phenomena in natural language,…

Computation and Language · Computer Science 2020-01-01 Dheeru Dua , Ananth Gottumukkala , Alon Talmor , Sameer Singh , Matt Gardner

Stay at home order during the COVID-19 helps flatten the curve but ironically, instigate mental health problems among the people who have Substance Use Disorders. Measuring the electrical activity signals in brain using off-the-shelf…

Human-Computer Interaction · Computer Science 2022-04-15 Emon Dey , Nirmalya Roy

Long-context multiple-choice question answering tasks require robust reasoning over extensive text sources. Since most of the pre-trained transformer models are restricted to processing only a few hundred words at a time, successful…

Information Retrieval · Computer Science 2025-01-28 Manish Singh , Manish Shrivastava

The rising rate of drug-related deaths in the United States, largely driven by fentanyl, requires timely and accurate surveillance. However, critical overdose data are often buried in free-text coroner reports, leading to delays and…

Understanding the neurobiology of opioid use disorder (OUD) using resting-state functional magnetic resonance imaging (rs-fMRI) may help inform treatment strategies to improve patient outcomes. Recent literature suggests time-frequency…

Neurons and Cognition · Quantitative Biology 2025-03-12 Ahmed Temtam , Megan A. Witherow , Liangsuo Ma , M. Shibly Sadique , F. Gerard Moeller , Khan M. Iftekharuddin

Opioids are an effective analgesic for acute and chronic pain, but also carry a considerable risk of addiction leading to millions of opioid use disorder (OUD) cases and tens of thousands of premature deaths in the United States yearly.…

Quantitative Methods · Quantitative Biology 2024-03-27 Sybille Légitime , Kaustubh Prabhu , Devin McConnell , Bing Wang , Dipak K. Dey , Derek Aguiar

This paper introduces the OPIAID algorithm, a novel approach for predicting and recommending personalized opioid dosages for individual patients. The algorithm optimizes pain management while minimizing opioid related adverse events (ORADE)…

Background: Electronic health records (EHRs) are a data source for opioid research. Opioid use disorder is known to be under-coded as a diagnosis, yet problematic opioid use can be documented in clinical notes. Objectives: Our goals were 1)…

Documents are central to many business systems, and include forms, reports, contracts, invoices or purchase orders. The information in documents is typically in natural language, but can be organized in various layouts and formats. There…

Information Retrieval · Computer Science 2021-10-08 Sumit Shekhar , Bhanu Prakash Reddy Guda , Ashutosh Chaubey , Ishan Jindal , Avneet Jain

Out-of-Distribution (OOD) detection is crucial for the reliable deployment of machine learning models in-the-wild, enabling accurate identification of test samples that differ from the training data distribution. Existing methods rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-08-15 Ruisong Han , Zongbo Han , Jiahao Zhang , Mingyue Cheng , Changqing Zhang

Neural dialog models often lack robustness to anomalous user input and produce inappropriate responses which leads to frustrating user experience. Although there are a set of prior approaches to out-of-domain (OOD) utterance detection, they…

Computation and Language · Computer Science 2019-05-27 Sungjin Lee , Igor Shalyminov
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