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Biomolecular machines consume free energy to break symmetry and make directed progress. Nonequilibrium ATP concentrations are the typical free energy source, with one cycle of a molecular machine consuming a certain number of ATP, providing…

Statistical Mechanics · Physics 2017-10-23 Aidan I Brown , David A Sivak

Quantum information processing relies on precise control of non-classical states in the presence of many uncontrolled environmental degrees of freedom -- requiring careful orchestration of how the relevant degrees of freedom interact with…

Quantum Physics · Physics 2024-02-06 Patrick M. Harrington , Erich Mueller , Kater Murch

Physical systems are often simulated using a stochastic computation where different final states result from identical initial states. Here, we derive the minimum energy cost of simulating a complex data set of a general physical system…

Data Analysis, Statistics and Probability · Physics 2015-05-30 Karoline Wiesner , Mile Gu , Elisabeth Rieper , Vlatko Vedral

High Throughput Computing (HTC) provides a convenient mechanism for running thousands of tasks. Many HTC systems exploit computers which are provisioned for other purposes by utilising their idle time - volunteer computing. This has great…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-23 A. Stephen McGough , Matthew Forshaw , John Brennan , Noura Al Moubayed , Stephen Bonner

Concept bottleneck models (CBMs) are interpretable models that first predict a set of semantically meaningful features, i.e., concepts, from observations that are subsequently used to condition a downstream task. However, the model's…

Machine Learning · Computer Science 2023-12-04 Renos Zabounidis , Ini Oguntola , Konghao Zhao , Joseph Campbell , Simon Stepputtis , Katia Sycara

In the recent years, scientific workflows gained more and more popularity. In scientific workflows, tasks are typically treated as black boxes. Dealing with their complex interrelations to identify optimization potentials and bottlenecks is…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-13 Ansgar Lößer , Joel Witzke , Florian Schintke , Björn Scheuermann

We investigate the computational efficiency and thermodynamic cost of the D-Wave quantum annealer under reverse-annealing with and without pausing. Our experimental results demonstrate that the combination of reverse-annealing and pausing…

Quantum Physics · Physics 2024-02-27 Tomasz Śmierzchalski , Zakaria Mzaouali , Sebastian Deffner , Bartłomiej Gardas

The principal obstacle to quantum information processing with many qubits is decoherence. One source of decoherence is spontaneous emission which causes loss of energy and information. Inability to control system parameters with high…

Quantum Physics · Physics 2009-11-10 Almut Beige , Hugo Cable , Peter L. Knight

quest for processing speed potential. In fact, we always get a fraction of the technically available computing power (so-called {\em theoretical peak}), and the gap is likely to go hand-to-hand with the hardware complexity of the target…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-23 Claude Tadonki

There does not exist a general positive correlation between important life-supporting properties and the entropy production rate. The simple reason is that nondissipative and time-symmetric kinetic aspects are also relevant for establishing…

Statistical Mechanics · Physics 2018-04-12 Marco Baiesi , Christian Maes

Chemical processes in closed systems are poorly controllable since they always relax to equilibrium. Living systems avoid this fate and give rise to a much richer diversity of phenomena by operating under nonequilibrium conditions. Recent…

Chemical Physics · Physics 2019-09-11 Emanuele Penocchio , Riccardo Rao , Massimiliano Esposito

Developing a thermodynamic theory of computation is a challenging task at the interface of non-equilibrium thermodynamics and computer science. In particular, this task requires dealing with difficulties such as stochastic halting times,…

Statistical Mechanics · Physics 2024-05-14 Gonzalo Manzano , Gülce Kardeş , Édgar Roldán , David Wolpert

Mobile-edge computing (MEC) has recently emerged as a promising paradigm to liberate mobile devices from increasingly intensive computation workloads, as well as to improve the quality of computation experience. In this paper, we…

Information Theory · Computer Science 2016-09-21 Yuyi Mao , Jun Zhang , S. H. Song , Khaled B. Letaief

We analyze how the amount of work dissipated by a fixed nonequilibrium process depends on the initial distribution over states. Specifically, we compare the amount of dissipation when the process is used with some specified initial…

Statistical Mechanics · Physics 2022-11-22 Artemy Kolchinsky , David H. Wolpert

Dissipation induced by interactions with an external environment typically hinders the performance of quantum computation, but in some cases can be turned out as a useful resource. We show the potential enhancement induced by dissipation in…

Many biological functions require the dynamics to be necessarily driven out-of-equilibrium. In contrast, in various contexts, a nonequilibrium dynamics at fast timescales can be described by an effective equilibrium dynamics at a slower…

Statistical Mechanics · Physics 2020-11-18 Amit Singh Vishen

One of the primary motivations of the research in the field of computation is to optimize the cost of computation. The major ingredient that a computer needs is the energy to run a process, i.e., the thermodynamic cost. The analysis of the…

Quantum Physics · Physics 2024-08-28 Pritam Chattopadhyay , Goutam Paul

Calculating free energy differences is a topic of substantial interest and has many applications including molecular docking and hydration, solvation, and binding free energies which is used in computational drug discovery. However, in…

Chemical Physics · Physics 2013-10-16 Asaf Farhi

Pipelining is a design technique for logical circuits that allows for higher throughput than circuits in which multiple computations are fed through the system one after the other. It allows for much faster computation than architectures in…

Computational Physics · Physics 2024-10-28 Ian Seet , Thomas E. Ouldridge , Jonathan P. K. Doye

In this paper, we revisit the communication vs. distributed computing trade-off, studied within the framework of MapReduce in [1]. An implicit assumption in the aforementioned work is that each server performs all possible computations on…

Information Theory · Computer Science 2017-05-26 Yahya H. Ezzeldin , Mohammed Karmoose , Christina Fragouli