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Retrosynthesis is essential for designing synthetic pathways for complex molecules and can be revolutionized by AI to automate and accelerate chemical synthesis planning for drug discovery and materials science. Here, we propose a…

Chemical Physics · Physics 2024-12-02 Seongeun Yun , Won Bo Lee

Predicting the chemical properties of compounds is crucial in discovering novel materials and drugs with specific desired characteristics. Recent significant advances in machine learning technologies have enabled automatic predictive…

Quantitative Methods · Quantitative Biology 2021-12-10 Yang Liu , Hisashi Kashima

Computational techniques are required for narrowing down the vast space of possibilities to plausible prebiotic scenarios, since precise information on the molecular composition, the dominant reaction chemistry, and the conditions for that…

Molecular Networks · Quantitative Biology 2018-02-07 Jakob L. Andersen , Christoph Flamm , Daniel Merkle , Peter F. Stadler

Automatic extraction of medical information from clinical documents poses several challenges: high costs of required clinical expertise, limited interpretability of model predictions, restricted computational resources and privacy…

Identification and verification of molecular properties such as side effects is one of the most important and time-consuming steps in the process of molecule synthesis. For example, failure to identify side effects before submission to…

Quantitative Methods · Quantitative Biology 2024-04-12 Collin Beaudoin , Koustubh Phalak , Swaroop Ghosh

Recent studies on Question Answering (QA) and Conversational QA (ConvQA) emphasize the role of retrieval: a system first retrieves evidence from a large collection and then extracts answers. This open-retrieval ConvQA setting typically…

Information Retrieval · Computer Science 2021-03-04 Chen Qu , Liu Yang , Cen Chen , W. Bruce Croft , Kalpesh Krishna , Mohit Iyyer

Platforms that support online commentary, from social networks to news sites, are increasingly leveraging machine learning to assist their moderation efforts. But this process does not typically provide feedback to the author that would…

Computation and Language · Computer Science 2021-02-12 Leo Laugier , John Pavlopoulos , Jeffrey Sorensen , Lucas Dixon

With the abundant amount of available online and offline text data, there arises a crucial need to extract the relation between phrases and summarize the main content of each document in a few words. For this purpose, there have been many…

Information Retrieval · Computer Science 2023-10-19 Serafina Kamp , Morteza Fayazi , Zineb Benameur-El , Shuyan Yu , Ronald Dreslinski

Drug-drug interaction event (DDIE) prediction is crucial for preventing adverse reactions and ensuring optimal therapeutic outcomes. However, existing methods often face challenges with imbalanced datasets, complex interaction mechanisms,…

Machine Learning · Computer Science 2026-03-16 Pengfei Liu , Jun Tao , Zhixiang Ren

Rapid discovery of new reactions and molecules in recent years has been facilitated by the advancements in high throughput screening, accessibility to a much more complex chemical design space, and the development of accurate molecular…

Molecular Networks · Quantitative Biology 2023-03-28 Vipul Mann , Venkat Venkatasubramanian

Systematic comparison of methods for relation extraction (RE) is difficult because many experiments in the field are not described precisely enough to be completely reproducible and many papers fail to report ablation studies that would…

Computation and Language · Computer Science 2021-07-14 Geeticka Chauhan , Matthew B. A. McDermott , Peter Szolovits

A chemical reaction mechanism (CRM) is a sequence of molecular-level events involving bond-breaking/forming processes, generating transient intermediates along the reaction pathway as reactants transform into products. Understanding such…

Chemical Physics · Physics 2024-07-16 Ajnabiul Hoque , Manajit Das , Mayank Baranwal , Raghavan B. Sunoj

The development of AI-assisted chemical synthesis tools requires comprehensive datasets covering diverse reaction types, yet current high-throughput experimental (HTE) approaches are expensive and limited in scope. Chemical literature…

Information Retrieval · Computer Science 2025-07-01 Kexin Chen , Yuyang Du , Junyou Li , Hanqun Cao , Menghao Guo , Xilin Dang , Lanqing Li , Jiezhong Qiu , Pheng Ann Heng , Guangyong Chen

Large language model editing methods frequently suffer from overfitting, wherein factual updates can propagate beyond their intended scope, overemphasizing the edited target even when it's contextually inappropriate. To address this…

Artificial Intelligence · Computer Science 2025-05-27 Haitian Zhong , Yuhuan Liu , Ziyang Xu , Guofan Liu , Qiang Liu , Shu Wu , Zhe Zhao , Liang Wang , Tieniu Tan

Most successful information extraction systems operate with access to a large collection of documents. In this work, we explore the task of acquiring and incorporating external evidence to improve extraction accuracy in domains where the…

Computation and Language · Computer Science 2016-09-29 Karthik Narasimhan , Adam Yala , Regina Barzilay

Term extraction is an information extraction task at the root of knowledge discovery platforms. Developing term extractors that are able to generalize across very diverse and potentially highly technical domains is challenging, as…

Computation and Language · Computer Science 2022-10-25 Francesco Fusco , Peter Staar , Diego Antognini

Parsing chemical reaction diagrams from scientific literature is challenging due to heterogeneous layouts, intertwined visual elements, and the difficulty of integrating recognition and reasoning. Existing vision-language models advance…

Artificial Intelligence · Computer Science 2026-05-28 Chuang Tang , Chenhao Lin , Yin Xu , Hao Wang , Jinrui Zhou , Xin Li , Mingjun Xiao , Enhong Chen

Chemical structure extraction from documents remains a hard problem due to both false positive identification of structures during segmentation and errors in the predicted structures. Current approaches rely on handcrafted rules and…

Machine Learning · Computer Science 2018-02-15 Joshua Staker , Kyle Marshall , Robert Abel , Carolyn McQuaw

Conversations on social media (SM) are increasingly being used to investigate social issues on the web, such as online harassment and rumor spread. For such issues, a common thread of research uses adversarial reactions, e.g., replies…

Computation and Language · Computer Science 2021-03-15 Sumeet Kumar , Ramon Villa Cox , Matthew Babcock , Kathleen M. Carley

Overall, the two main contributions of this work include the application of sentence simplification to association extraction as described above, and the use of distributional semantics for concept extraction. The proposed work on concept…

Computation and Language · Computer Science 2011-09-13 Siddhartha Jonnalagadda
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