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Autism Spectrum Disorder (ASD) involves diverse neurodevelopmental syndromes with significant deficits in communication, motor behaviours, emotional and social comprehension. Often, individuals with ASD exhibit comorbid conditions, one of…

Neurons and Cognition · Quantitative Biology 2024-03-27 Dolcy Dhar , Manasi Chaturvedi , Saanvi Sehwag , Chehak Malhotra , Udit , Chetan Saraf , Mrinmoy Chakrabarty

Early detection of autism, a neurodevelopmental disorder marked by social communication challenges, is crucial for timely intervention. Recent advancements have utilized naturalistic home videos captured via the mobile application…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Marie Huynh , Aaron Kline , Saimourya Surabhi , Kaitlyn Dunlap , Onur Cezmi Mutlu , Mohammadmahdi Honarmand , Parnian Azizian , Peter Washington , Dennis P. Wall

Human brain development is rapid during infancy and early childhood. Many disease processes impair this development. Therefore, brain developmental age estimation (BDAE) is essential for all diseases affecting cognitive development. Brain…

Image and Video Processing · Electrical Eng. & Systems 2019-11-06 Mahdieh Shabanian , Eugene C. Eckstein , Hao Chen , John P. DeVincenzo

The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

Structural magnetic resonance imaging (sMRI) can identify subtle brain changes due to its high contrast for soft tissues and high spatial resolution. It has been widely used in diagnosing neurological brain diseases, such as Alzheimer…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Xin Zhang , Liangxiu Han , Lianghao Han , Haoming Chen , Darren Dancey , Daoqiang Zhang

Deep learning models for MRI classification face two recurring problems: they are typically limited by low sample size, and are abstracted by their own complexity (the "black box problem"). In this paper, we train a convolutional neural…

Quantitative Methods · Quantitative Biology 2020-05-28 Matthew Leming , Juan Manuel Górriz , John Suckling

Autism Spectrum Disorders are associated with atypical movements, of which stereotypical motor movements (SMMs) interfere with learning and social interaction. The automatic SMM detection using inertial measurement units (IMU) remains…

Computer Vision and Pattern Recognition · Computer Science 2017-09-19 Nastaran Mohammadian Rad , Seyed Mostafa Kia , Calogero Zarbo , Twan van Laarhoven , Giuseppe Jurman , Paola Venuti , Elena Marchiori , Cesare Furlanello

Conventionally, evaluation for the diagnosis of Autism spectrum disorder is done by a trained specialist through questionnaire-based formal assessments and by observation of behavioral cues under various settings to capture the early…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Vaibhavi Lokegaonkar , Vijay Jaisankar , Pon Deepika , Madhav Rao , T K Srikanth , Sarbani Mallick , Manjit Sodhi

Supervised deep learning techniques show promise in medical image analysis. However, they require comprehensive annotated data sets, which poses challenges, particularly for rare diseases. Consequently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Finn Behrendt , Debayan Bhattacharya , Lennart Maack , Julia Krüger , Roland Opfer , Robin Mieling , Alexander Schlaefer

Mobile digital therapeutics for autism spectrum disorder (ASD) often target emotion recognition and evocation, which is a challenge for children with ASD. While such mobile applications often use computer vision machine learning (ML) models…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Ali Kargarandehkordi , Matti Kaisti , Peter Washington

Normative modeling is an emerging and promising approach to effectively study disorder heterogeneity in individual participants. In this study, we propose a novel normative modeling method by combining conditional variational autoencoder…

Machine Learning · Computer Science 2022-11-17 Xuetong Wang , Kanhao Zhao , Rong Zhou , Alex Leow , Ricardo Osorio , Yu Zhang , Lifang He

The objective of this study is to derive functional networks for the autism spectrum disorder (ASD) population using the group ICA and dictionary learning model together and to classify ASD and typically developing (TD) participants using…

Neurons and Cognition · Quantitative Biology 2021-06-17 Xin Yang , Ning Zhang , Donglin Wang

Dementia, a prevalent neurodegenerative condition, is a major manifestation of Alzheimer's disease (AD). As the condition progresses from mild to severe, it significantly impairs the individual's ability to perform daily tasks…

Machine Learning · Computer Science 2023-11-06 Md Gulzar Hussain , Ye Shiren

Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Marcel Bengs , Finn Behrendt , Max-Heinrich Laves , Julia Krüger , Roland Opfer , Alexander Schlaefer

Caregivers of individuals with autism spectrum disorder (ASD) often find the 77-item Autism Treatment Evaluation Checklist (ATEC) burdensome, limiting its use for routine monitoring. This study introduces a generalizable machine learning…

Applications · Statistics 2025-11-03 Audrey Dong , Claire Xu , Samuel R. Guo , Kevin Yang , Xue-Jun Kong

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence…

Image and Video Processing · Electrical Eng. & Systems 2021-01-11 Ali Nawaz , Syed Muhammad Anwar , Rehan Liaqat , Javid Iqbal , Ulas Bagci , Muhammad Majid

Neuroimaging biomarkers that distinguish between typical brain aging and Alzheimer's disease (AD) are valuable for determining how much each contributes to cognitive decline. Machine learning models can derive multi-variate brain change…

This paper presents a comprehensive study focused on disentangling hippocampal shape variations from diffusion tensor imaging (DTI) datasets within the context of neurological disorders. Leveraging a Mesh Variational Autoencoder (VAE)…

Computer Vision and Pattern Recognition · Computer Science 2024-11-12 Jakaria Rabbi , Johannes Kiechle , Christian Beaulieu , Nilanjan Ray , Dana Cobzas

Increasing the volume of training data can enable the auxiliary diagnostic algorithms for Autism Spectrum Disorder (ASD) to learn more accurate and stable models. However, due to the significant heterogeneity and domain shift in rs-fMRI…

Neurons and Cognition · Quantitative Biology 2025-07-11 Yiqian Luo , Qiurong Chen , Fali Li , Peng Xu , Yangsong Zhang

Machine learning methods, such as deep learning, show promising results in the medical domain. However, the lack of interpretability of these algorithms may hinder their applicability to medical decision support systems. This paper studies…

Signal Processing · Electrical Eng. & Systems 2021-07-23 Juan Manuel Mayor-Torres , Mirco Ravanelli , Sara E. Medina-DeVilliers , Matthew D. Lerner , Giuseppe Riccardi