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\textbf{Objective:} Alzheimer's disease (AD) is the most prevalent form of dementia worldwide, encompassing a prodromal stage known as Mild Cognitive Impairment (MCI), where patients may either progress to AD or remain stable. The objective…

Mild cognitive impairment(MCI) is a precursor of Alzheimer's disease(AD), and the detection of MCI is of great clinical significance. Analyzing the structural brain networks of patients is vital for the recognition of MCI. However, the…

Neurons and Cognition · Quantitative Biology 2022-08-19 Heng Kong , Shuqiang Wang

Representation learning methods that transform encoded data (e.g., diagnosis and drug codes) into continuous vector spaces (i.e., vector embeddings) are critical for the application of deep learning in healthcare. Initial work in this area…

Machine Learning · Computer Science 2019-07-23 Khushbu Agarwal , Tome Eftimov , Raghavendra Addanki , Sutanay Choudhury , Suzanne Tamang , Robert Rallo

Early detection of neurodegenerative disorders is an important open problem, since early diagnosis and treatment may yield a better prognosis. Researchers have recently sought to leverage advances in machine learning algorithms to detect…

Machine Learning · Computer Science 2024-09-23 Abhishek Jaiswal , Nisheeth Srivastava

Omics data analysis is crucial for studying complex diseases, but its high dimensionality and heterogeneity challenge classical statistical and machine learning methods. Graph neural networks have emerged as promising alternatives, yet the…

Graph deep learning has recently emerged as a powerful ML concept allowing to generalize successful deep neural architectures to non-Euclidean structured data. Such methods have shown promising results on a broad spectrum of applications…

Machine Learning · Computer Science 2022-05-16 Anees Kazi , Luca Cosmo , Seyed-Ahmad Ahmadi , Nassir Navab , Michael Bronstein

ASD is a complicated neurodevelopmental disorder marked by variation in symptom presentation and neurological underpinnings, making early and objective diagnosis extremely problematic. This paper presents a Graph Convolutional Network (GCN)…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Adnan Ferdous Ashrafi , Hasanul Kabir

Functional MRI is a neuroimaging technique that analyzes the functional activity of the brain by measuring blood-oxygen-level-dependent signals throughout the brain. The derived functional features can be used for investigating brain…

Neurons and Cognition · Quantitative Biology 2026-02-16 Giorgio Dolci , Silvia Saglia , Lorenza Brusini , Vince D. Calhoun , Ilaria Boscolo Galazzo , Gloria Menegaz

Functional connectivity analysis is an important tool for characterizing interactions among brain regions, particularly in studies of neurodegenerative disorders such as Alzheimer's disease (AD). Gaussian graphical models (GGMs) provide a…

Methodology · Statistics 2026-04-14 Panpan Zhang , Shiying Xiao , W. Hudson Robb , Dandan Liu , Angela L. Jefferson , Jun Yan

Subjective cognitive decline (SCD) is a preclinical stage of Alzheimer's disease (AD) which occurs even before mild cognitive impairment (MCI). Progressive SCD will convert to MCI with the potential of further evolving to AD. Therefore,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Hao Guan , Ling Yue , Pew-Thian Yap , Shifu Xiao , Andrea Bozoki , Mingxia Liu

Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Hongming Li , Yong Fan

There is a recent trend to leverage the power of graph neural networks (GNNs) for brain-network based psychiatric diagnosis, which,in turn, also motivates an urgent need for psychiatrists to fully understand the decision behavior of the…

Machine Learning · Statistics 2024-01-30 Kaizhong Zheng , Shujian Yu , Badong Chen

Alzheimer's disease (AD) is a neurodegenerative disease known to affect brain functional connectivity (FC). Linear FC measures have been applied to study the differences in AD by splitting neurophysiological signals such as…

Neurons and Cognition · Quantitative Biology 2022-06-14 Dominik Klepl , Fei He , Min Wu , Daniel J. Blackburn , Ptolemaios G. Sarrigiannis

Accurate quantification of cerebral blood flow (CBF) is essential for the diagnosis and assessment of cerebrovascular diseases such as Moyamoya, carotid stenosis, aneurysms, and stroke. Positron emission tomography (PET) is currently…

Image and Video Processing · Electrical Eng. & Systems 2022-02-15 Ramy Hussein , Moss Zhao , David Shin , Jia Guo , Kevin T. Chen , Rui D. Armindo , Guido Davidzon , Michael Moseley , Greg Zaharchuk

Alzheimer's disease is a progressive neurodegenerative disorder that remains challenging to predict due to its multifactorial etiology and the complexity of multimodal clinical data. Accurate forecasting of clinically relevant biomarkers,…

Machine Learning · Computer Science 2026-02-03 Yilang Ding , Jiawen Ren , Jiaying Lu , Gloria Hyunjung Kwak , Armin Iraji , Shengpu Tang , Alex Fedorov

Brain tumors result from abnormal cell growth in brain tissue. If undiagnosed, they cause neurological deficits, including cognitive impairment, motor dysfunction, and sensory loss. As tumors grow, intracranial pressure increases,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-19 Shravan Venkatraman , Pandiyaraju V , Abeshek A , Aravintakshan S A , Pavan Kumar S , Kannan A , Madhan S

Generative models based on deep learning have shown significant potential in medical imaging, particularly for modality transformation and multimodal fusion in MRI-based brain imaging. This study introduces GM-LDM, a novel framework that…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Hu Xu , Yang Jingling , Jia Sihan , Bi Yuda , Calhoun Vince

Insomnia affects a vast population of the world and can have a wide range of causes. Existing treatments for insomnia have been linked with many side effects like headaches, dizziness, etc. As such, there is a clear need for improved…

Signal Processing · Electrical Eng. & Systems 2025-07-22 Kevin Monteiro , Sam Nallaperuma-Herzberg , Martina Mason , Steve Niederer

This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive…

Brain-Computer Interfaces (BCIs) rely on accurately decoding electroencephalography (EEG) motor imagery (MI) signals for effective device control. Graph Neural Networks (GNNs) outperform Convolutional Neural Networks (CNNs) in this regard,…

Signal Processing · Electrical Eng. & Systems 2024-05-03 Htoo Wai Aung , Jiao Jiao Li , Yang An , Steven W. Su
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