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The integration of Convolutional Neural Network (ConvNet) and Transformer has emerged as a strong candidate for image registration, leveraging the strengths of both models and a large parameter space. However, this hybrid model, treating…

Computer Vision and Pattern Recognition · Computer Science 2024-08-30 Yufeng Zhou , Wenming Cao

Deep learning-based methods have recently demonstrated promising results in deformable image registration for a wide range of medical image analysis tasks. However, existing deep learning-based methods are usually limited to small…

Image and Video Processing · Electrical Eng. & Systems 2020-07-01 Tony C. W. Mok , Albert C. S. Chung

Spatial transformations that capture population-level morphological statistics are critical for medical image analysis. Commonly used smoothness regularizers for image registration fail to integrate population statistics, leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Mokshagna Sai Teja Karanam , Krithika Iyer , Sarang Joshi , Shireen Elhabian

In recent years, learning-based image registration methods have gradually moved away from direct supervision with target warps to instead use self-supervision, with excellent results in several registration benchmarks. These approaches…

Computer Vision and Pattern Recognition · Computer Science 2022-05-17 Sean I. Young , Yaël Balbastre , Adrian V. Dalca , William M. Wells , Juan Eugenio Iglesias , Bruce Fischl

Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function that…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Malte Hoffmann , Andrew Hoopes , Douglas N. Greve , Bruce Fischl , Adrian V. Dalca

As in other areas of medical image analysis, e.g. semantic segmentation, deep learning is currently driving the development of new approaches for image registration. Multi-scale encoder-decoder network architectures achieve state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 Lasse Hansen , Mattias P. Heinrich

Point Cloud Registration (PCR) is a critical and challenging task in computer vision. One of the primary difficulties in PCR is identifying salient and meaningful points that exhibit consistent semantic and geometric properties across…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Qianliang Wu , Yaqing Ding , Lei Luo , Haobo Jiang , Shuo Gu , Chuanwei Zhou , Jin Xie , Jian Yang

Normalization Layers (NLs) are widely used in modern deep-learning architectures. Despite their apparent simplicity, their effect on optimization is not yet fully understood. This paper introduces a spherical framework to study the…

Machine Learning · Computer Science 2022-05-20 Simon Roburin , Yann de Mont-Marin , Andrei Bursuc , Renaud Marlet , Patrick Pérez , Mathieu Aubry

We present VoxelMorph, a fast learning-based framework for deformable, pairwise medical image registration. Traditional registration methods optimize an objective function for each pair of images, which can be time-consuming for large…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Guha Balakrishnan , Amy Zhao , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

Brain age prediction serves as a powerful framework for assessing brain status and detecting deviations associated with neurodevelopmental and neurodegenerative disorders. However, most existing approaches emphasize whole-brain age…

Neurons and Cognition · Quantitative Biology 2026-02-10 Rongzhao He , Dalin Zhu , Ying Wang , Songhong Yue , Leilei Zhao , Yu Fu , Dan Wu , Bin Hu , Weihao Zheng

Deep learning-based image registration methods have shown state-of-the-art performance and rapid inference speeds. Despite these advances, many existing approaches fall short in capturing spatially varying information in non-local regions…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Xinxing Cheng , Tianyang Zhang , Wenqi Lu , Qingjie Meng , Alejandro F. Frangi , Jinming Duan

Deformable image registration plays a fundamental role in medical image analysis by enabling spatial alignment of anatomical structures across subjects. While recent deep learning-based approaches have significantly improved computational…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jiaqi Shang , Haojin Wu , Yinyi Lai , Zongyu Li , Chenghao Zhang , Jia Guo

Deformable registration is crucial in medical imaging. Several existing applications include lesion tracking, probabilistic atlas generation, and treatment response evaluation. However, current methods often lack robustness and…

Image and Video Processing · Electrical Eng. & Systems 2026-03-04 Yunzheng Zhu , Aichi Chien , Kimaya kulkarni , Luoting Zhuang , Stephen Park , Ricky Savjani , Daniel Low , William Hsu

Registration of point clouds related by rigid transformations is one of the fundamental problems in computer vision. However, a solution to the practical scenario of aligning sparsely and differently sampled observations in the presence of…

Computer Vision and Pattern Recognition · Computer Science 2021-12-21 Natalie Lang , Joseph M. Francos

Accurate and robust tracking and reconstruction of the surgical scene is a critical enabling technology toward autonomous robotic surgery. Existing algorithms for 3D perception in surgery mainly rely on geometric information, while we…

Image and Video Processing · Electrical Eng. & Systems 2023-02-21 Shan Lin , Albert J. Miao , Jingpei Lu , Shunkai Yu , Zih-Yun Chiu , Florian Richter , Michael C. Yip

Deep learning-based medical image segmentation and surface mesh generation typically involve a sequential pipeline from image to segmentation to meshes, often requiring large training datasets while making limited use of prior geometric…

While there has been significant progress in evaluating and comparing different representations for learning on protein data, the role of surface-based learning approaches remains not well-understood. In particular, there is a lack of…

Machine Learning · Computer Science 2025-10-23 Vincent Mallet , Souhaib Attaiki , Yangyang Miao , Bruno Correia , Maks Ovsjanikov

With this work, we release CLAIRE, a distributed-memory implementation of an effective solver for constrained large deformation diffeomorphic image registration problems in three dimensions. We consider an optimal control formulation. We…

Optimization and Control · Mathematics 2020-09-01 Andreas Mang , Amir Gholami , Christos Davatzikos , George Biros

Deep learning based deformable registration methods have become popular in recent years. However, their ability to generalize beyond training data distribution can be poor, significantly hindering their usability. LUMIR brain registration…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Joel Honkamaa , Pekka Marttinen

Deep learning has revolutionized medical image registration by achieving unprecedented speeds, yet its clinical application is hindered by a limited ability to generalize beyond the training domain, a critical weakness given the typically…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Fengting Zhang , Yue He , Qinghao Liu , Yaonan Wang , Xiang Chen , Hang Zhang