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An introduction to the emerging fusion of machine learning and causal inference. The book presents ideas from classical structural equation models (SEMs) and their modern AI equivalent, directed acyclical graphs (DAGs) and structural causal…

Deep generative models have emerged as a popular machine learning-based approach for inverse design problems in the life sciences. However, these problems often require sampling new designs that satisfy multiple properties of interest in…

The graph structure of a Bayesian network (BN) can be learned from data using the well-known score-and-search approach. Previous work has shown that incorporating structured representations of the conditional probability distributions…

Machine Learning · Computer Science 2022-06-22 Charupriya Sharma , Peter van Beek

Promising results have driven a recent surge of interest in continuous optimization methods for Bayesian network structure learning from observational data. However, there are theoretical limitations on the identifiability of underlying…

We study constraint-based structure learning of Markov networks and Bayesian networks in the presence of an unreliable conditional independence oracle that makes at most a bounded number of errors. For Markov networks, we observe that a low…

Machine Learning · Computer Science 2026-03-11 Juha Harviainen , Pekka Parviainen , Vidya Sagar Sharma

Causal discovery from observational and interventional data is challenging due to limited data and non-identifiability: factors that introduce uncertainty in estimating the underlying structural causal model (SCM). Selecting experiments…

Machine Learning · Computer Science 2022-10-24 Panagiotis Tigas , Yashas Annadani , Andrew Jesson , Bernhard Schölkopf , Yarin Gal , Stefan Bauer

Studying the neurological, genetic and evolutionary basis of human vocal communication mechanisms using animal vocalization models is an important field of neuroscience. The data sets typically comprise structured sequences of syllables or…

Unveil, model, and comprehend the causal mechanisms underpinning natural phenomena stand as fundamental endeavors across myriad scientific disciplines. Meanwhile, new knowledge emerges when discovering causal relationships from data.…

Machine Learning · Computer Science 2023-12-13 Jiaxuan Liang , Jun Wang , Guoxian Yu , Shuyin Xia , Guoyin Wang

Traditional approaches to Bayes net structure learning typically assume little regularity in graph structure other than sparseness. However, in many cases, we expect more systematicity: variables in real-world systems often group into…

Machine Learning · Computer Science 2012-07-02 Vikash Mansinghka , Charles Kemp , Thomas Griffiths , Joshua Tenenbaum

Structural Causal Models (SCMs) offer a principled framework to reason about interventions and support out-of-distribution generalization, which are key goals in scientific discovery. However, the task of learning SCMs from observed data…

Machine Learning · Computer Science 2026-04-06 Divyat Mahajan , Jannes Gladrow , Agrin Hilmkil , Cheng Zhang , Meyer Scetbon

High dimensional and heterogeneous count data are collected in various applied fields. In this paper, we look closely at high-resolution sequencing data on the microbiome, which have enabled researchers to study the genomes of entire…

Methodology · Statistics 2024-01-12 Veronica Vinciotti , Pariya Behrouzi , Reza Mohammadi

Causal structure learning is a key problem in many domains. Causal structures can be learnt by performing experiments on the system of interest. We address the largely unexplored problem of designing a batch of experiments that each…

Machine Learning · Computer Science 2021-11-25 Scott Sussex , Andreas Krause , Caroline Uhler

Inferring causal relationships from observational data is rarely straightforward, but the problem is especially difficult in high dimensions. For these applications, causal discovery algorithms typically require parametric restrictions or…

Methodology · Statistics 2022-06-29 David S. Watson , Ricardo Silva

Markov networks are popular models for discrete multivariate systems where the dependence structure of the variables is specified by an undirected graph. To allow for more expressive dependence structures, several generalizations of Markov…

Methodology · Statistics 2021-03-30 Johan Pensar , Henrik Nyman , Jukka Corander

In this note we explore a fully unsupervised deep-learning framework for simulating non-linear structural equation models from observational training data. The main contribution of this note is an architecture for applying moment-matching…

Machine Learning · Statistics 2020-07-28 Michael Park

We propose an extension of the Contextual Graph Markov Model, a deep and probabilistic machine learning model for graphs, to model the distribution of edge features. Our approach is architectural, as we introduce an additional Bayesian…

Machine Learning · Computer Science 2023-08-21 Daniele Atzeni , Federico Errica , Davide Bacciu , Alessio Micheli

Developing feature selection algorithms that move beyond a pure correlational to a more causal analysis of observational data is an important problem in the sciences. Several algorithms attempt to do so by discovering the Markov blanket of…

Machine Learning · Statistics 2014-05-06 Eric V. Strobl , Shyam Visweswaran

In this paper, the relationship between probabilistic graphical models, in particular Bayesian networks, and causal diagrams, also called structural causal models, is studied. Structural causal models are deterministic models, based on…

Artificial Intelligence · Computer Science 2026-04-24 Peter J. F. Lucas , Eleonora Zullo , Fabio Stella

This paper studies the fundamental problem of learning multi-layer generator models. The multi-layer generator model builds multiple layers of latent variables as a prior model on top of the generator, which benefits learning complex data…

Computer Vision and Pattern Recognition · Computer Science 2023-10-13 Jiali Cui , Ying Nian Wu , Tian Han

It is well known in the literature that the problem of learning the structure of Bayesian networks is very hard to tackle: its computational complexity is super-exponential in the number of nodes in the worst case and polynomial in most…

Computation · Statistics 2017-04-14 Marco Scutari