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There are several tools available to infer phylogenetic trees, which depict the evolutionary relationships among biological entities such as viral and bacterial strains in infectious outbreaks, or cancerous cells in tumor progression trees.…

Data Structures and Algorithms · Computer Science 2023-12-22 António Pedro Branco , Cátia Vaz , Alexandre P. Francisco

Phylogenetic trees are a central tool in understanding evolution. They are typically inferred from sequence data, and capture evolutionary relationships through time. It is essential to be able to compare trees from different data sources…

Populations and Evolution · Quantitative Biology 2017-10-31 Michelle Kendall , Caroline Colijn

Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…

Populations and Evolution · Quantitative Biology 2026-04-28 Aleksandr Koshkarov , Nadia Tahiri

A metric phylogenetic tree relating a collection of taxa induces weighted rooted triples and weighted quartets for all subsets of three and four taxa, respectively. New intertaxon distances are defined that can be calculated from these…

Populations and Evolution · Quantitative Biology 2020-02-12 Samaneh Yourdkhani , John A. Rhodes

Phylogenetic trees are the fundamental mathematical representation of evolutionary processes in biology. They are also objects of interest in pure mathematics, such as algebraic geometry and combinatorics, due to their discrete geometry.…

Metric Geometry · Mathematics 2022-07-01 Anthea Monod , Bo Lin , Ruriko Yoshida , Qiwen Kang

Tropical geometry with the max-plus algebra has been applied to statistical learning models over tree spaces because geometry with the tropical metric over tree spaces has some nice properties such as convexity in terms of the tropical…

Combinatorics · Mathematics 2021-11-02 Ruriko Yoshida , Shelby Cox

Classification of gene trees is an important task both in the analysis of multi-locus phylogenetic data, and assessment of the convergence of Markov Chain Monte Carlo (MCMC) analyses used in Bayesian phylogenetic tree reconstruction. The…

Combinatorics · Mathematics 2024-06-10 Georgios Aliatimis , Ruriko Yoshida , Burak Boyaci , James A. Grant

We present a new method for inferring species trees from multi-copy gene trees. Our method is based on a generalization of the Robinson-Foulds (RF) distance to multi-labeled trees (mul-trees), i.e., gene trees in which multiple leaves can…

Data Structures and Algorithms · Computer Science 2012-10-10 Ruchi Chaudhary , J. Gordon Burleigh , David Fernández-Baca

Much evidence from biological theory and empirical data indicates that, gene tree, phylogenetic trees reconstructed from different genes (loci), do not have to have exactly the same tree topologies. Such incongruence between gene trees…

Populations and Evolution · Quantitative Biology 2023-07-13 Ruriko Yoshida , David Barnhill , Keiji Miura , Daniel Howe

We propose a statistical method to test whether two phylogenetic trees with given alignments are significantly incongruent. Our method compares the two distributions of phylogenetic trees given by the input alignments, instead of comparing…

Populations and Evolution · Quantitative Biology 2010-04-14 Elissaveta Arnaoudova , David Haws , Peter Huggins , Jerzy W. Jaromczyk , Neil Moore , Chris Schardl , Ruriko Yoshida

Phylogenomics is a new field which applies to tools in phylogenetics to genome data. Due to a new technology and increasing amount of data, we face new challenges to analyze them over a space of phylogenetic trees. Because a space of…

Combinatorics · Mathematics 2020-05-15 Ruriko Yoshida

Phylogenetic trees provide a fundamental representation of evolutionary relationships, yet the combinatorial explosion of possible tree topologies renders inference computationally challenging. Classical approaches to characterizing tree…

Populations and Evolution · Quantitative Biology 2025-12-29 Samir Bhatt , John Sabol , Papri Dey , Matthew J. Penn , David Duchene , Ruriko Yoshida

The Robinson-Foulds (RF) metric is arguably the most widely used measure of phylogenetic tree similarity, despite its well-known shortcomings: For example, moving a single taxon in a tree can result in a tree that has maximum distance to…

Data Structures and Algorithms · Computer Science 2013-08-02 Sebastian Böcker , Stefan Canzar , Gunnar W. Klau

Phylogenetics is now fundamental in life sciences, providing insights into the earliest branches of life and the origins and spread of epidemics. However, finding suitable phylogenies from the vast space of possible trees remains…

Populations and Evolution · Quantitative Biology 2024-01-24 Matthew J Penn , Neil Scheidwasser , Joseph Penn , Christl A Donnelly , David A Duchêne , Samir Bhatt

We introduce new methods for phylogenetic tree quartet construction by using machine learning to optimize the power of phylogenetic invariants. Phylogenetic invariants are polynomials in the joint probabilities which vanish under a model of…

Populations and Evolution · Quantitative Biology 2007-05-23 Nicholas Eriksson , Yuan Yao

The search for similarity and dissimilarity measures on phylogenetic trees has been motivated by the computation of consensus trees, the search by similarity in phylogenetic databases, and the assessment of clustering results in…

Populations and Evolution · Quantitative Biology 2011-11-09 Francesc Rossello , Gabriel Valiente

A phylogenetic tree is an important way in Bioinformatics to find the evolutionary relationship among biological species. In this research, a proposed model is described for the estimation of a phylogenetic tree for a given set of data. To…

Populations and Evolution · Quantitative Biology 2025-09-03 S M Rafiuddin

We study the behavior of phylogenetic tree shapes in the tropical geometric interpretation of tree space. Tree shapes are formally referred to as tree topologies; a tree topology can also be thought of as a tree combinatorial type, which is…

Combinatorics · Mathematics 2023-01-25 Bo Lin , Anthea Monod , Ruriko Yoshida

Given a tree $T$, its path polytope is the convex hull of the edge indicator vectors for the paths between any two distinct leaves in $T$. These polytopes arise naturally in polyhedral geometry and applications, such as phylogenetics,…

Combinatorics · Mathematics 2025-03-03 Amer Goel , Aida Maraj , Alvaro Ribot

In this work, we introduce a Tropical Axial Attention neural reasoning architecture that replaces vanilla softmax dot-product attention with max-plus operators, inducing a piecewise-linear structure aligned with dynamic programming…

Populations and Evolution · Quantitative Biology 2026-05-15 Chris Teska , Kurt Pasque , Ruriko Yoshida , Baran Hashemi
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