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Biocompatible nanoscale probes for sensitive detection of paramagnetic species and molecules associated with their (bio)chemical transformations would provide a desirable tool for a better understanding of cellular redox processes. Here, we…

Nitrogen-vacancy (NV) centers in diamond provide a versatile quantum sensing platform for biological imaging through magnetic field detection, offering unlimited photostability and the ability to perform long-term observations without…

Biological Physics · Physics 2026-03-26 A. Pointner , D. Thalheim , S. Belasi , L. Heinen , L. R. Carnell , C. Janko , R. Tietze , C. Alexiou , R. Schneider-Stock , R. Nagy

High biocompatibility, variable size ranging from ~ 5 nm, stable luminescence from its color centers and simple carbon chemistry for biomolecule grafting make nanodiamond (ND) particles an attractive alternative to molecular dyes for…

We demonstrate fluorescence thermometry techniques with sensitivities approaching 10 mK Hz^(-1/2) based on the spin-dependent photoluminescence of nitrogen vacancy (NV) centers in diamond. These techniques use dynamical decoupling protocols…

Mesoscale and Nanoscale Physics · Physics 2013-05-24 David M. Toyli , Charles F. de las Casas , David J. Christle , Viatcheslav V. Dobrovitski , David D. Awschalom

Nitrogen-Vacancy (NV) spin in diamond is a versatile quantum sensor, being able to measure physical quantities such as magnetic field, electric field, temperature, and pressure. In the present work, we demonstrate a multiplexed sensing of…

In drug discovery research there is a clear and urgent need for non-invasive detection of cell membrane ion channel operation with wide-field capability. Existing techniques are generally invasive, require specialized nano structures, or…

An important feature of strong correlated electron systems is the tunability between interesting ground states such as unconventional superconductivity and exotic magnetism. Pressure is a clean, continuous and systematic tuning parameter.…

Mesoscale and Nanoscale Physics · Physics 2020-02-04 King Yau Yip , Kin On Ho , King Yiu Yu , Yang Chen , Wei Zhang , S. Kasahara , Y. Mizukami , T. Shibauchi , Y. Matsuda , Swee K. Goh , Sen Yang

The transition of materials and devices to nanometer, atomic, and quantum scales makes thermal characterization increasingly challenging, driving the need for advanced nanoscale thermometry. Fluorescence nanothermometry has emerged as a…

The negatively-charged nitrogen vacancy (NV$^-$) centre in diamond is a remarkable optical quantum sensor for a range of applications including, nanoscale thermometry, magnetometry, single photon generation, quantum computing, and…

We report progress toward a CMOS-integrated quantum diamond biosensing platform that combines nitrogen-vacancy (NV) centers in diamond with a custom 40 nm CMOS Single-Photon Avalanche Diode (SPAD) array. The system integrates on-chip active…

Nanodiamonds containing luminescent point defects are widely explored for applications in quantum bio-sensing such as nanoscale magnetometry, thermometry, and electrometry. A key challenge in the development of such applications is a large…

Optics · Physics 2023-02-08 Qiang Sun , Shuo Li , Taras Plakhotnik , Andrew D. Greentree

Fluorescent defects in non-cytotoxic diamond nanoparticles are candidates for qubits in quantum computing, optical labels in biomedical imaging and sensors in magnetometry. For each application these defects need to be optically and…

Materials Science · Physics 2009-08-26 Carlo Bradac , Torsten Gaebel , Nishen Naidoo , James R. Rabeau , Amanda S. Barnard

Luminescence thermometry and manometry are exponentially growing areas dealing with the optical detection of temperature and pressure, respectively, being appealing alternatives for conventional thermometers and manometers. The main benefit…

Materials Science · Physics 2025-05-22 Lukasz Marciniak , Maja Szymczak , Przemyslaw Wozny , Marcin Runowski

Motivated by the recent development of fast and ultra-sensitive thermometry in nanoscale systems, we investigate quantum calorimetric detection of individual heat pulses in the sub-meV energy range. We propose a hybrid superconducting…

Mesoscale and Nanoscale Physics · Physics 2018-11-28 F. Brange , P. Samuelsson , B. Karimi , J. P. Pekola

In nanomechanical photothermal absorption spectroscopy and microscopy, the measured substance becomes a part of the detection system itself, inducing a nanomechanical resonance frequency shift upon thermal relaxation. Suspended,…

Instrumentation and Detectors · Physics 2023-06-30 Robert G. West , Kostas Kanellopulos , Silvan Schmid

Heat generation and temperature reading at the nanoscale have attracted increasing attention due to their direct relevance in thermal therapeutic approaches. Consequently, huge progress has been made toward the design of dual-function…

Traditional cellular force-sensing techniques, such as traction force microscopy (TFM), are predominantly limited to measuring linear tractions, overlooking and technically unable to capture the nanoscale torsional forces that are critical…

The NV center in a diamond is a quantum sensor with exceptional quality for highly sensitive nanoscale analysis of NMR spectra and thermometry. In this study, we investigate nanoscale phase change detection of lipid bilayers utilizing…

Many essential cellular functions depend on the viscoelastic properties of the cytoplasm. While techniques such as optical tweezers and atomic force microscopy can measure these properties, their reliance on localized probes prevents…

Optical-based nanothermometry represents a transformative approach for precise temperature measurements at the nanoscale, which finds versatile applications across biology, medicine, and electronics. The assembly of ratiometric fluorescent…

Optics · Physics 2025-04-01 Mahshid Iraniparast , Nishant Kumar , Igor Sokolov