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Transcription factors regulate gene expression, but how these proteins recognize and specifically bind to their DNA targets is still debated. Machine learning models are effective means to reveal interaction mechanisms. Here we studied the…

Quantum Physics · Physics 2018-03-02 Richard Y. Li , Rosa Di Felice , Remo Rohs , Daniel A. Lidar

Quantum annealing is a promising paradigm for building practical quantum computers. Compared to other approaches, quantum annealing technology has been scaled up to a larger number of qubits. On the other hand, deep learning has been…

Quantum Physics · Physics 2021-07-07 Michele Sasdelli , Tat-Jun Chin

Feature selection is a technique in statistical prediction modeling that identifies features in a record with a strong statistical connection to the target variable. Excluding features with a weak statistical connection to the target…

Quantum Physics · Physics 2025-11-07 Andrew Vlasic , Hunter Grant , Salvatore Certo

I describe how real quantum annealers may be used to perform local (in state space) searches around specified states, rather than the global searches traditionally implemented in the quantum annealing algorithm. Such protocols will have…

Quantum Physics · Physics 2017-06-26 Nicholas Chancellor

We demonstrate the feasibility of framing a classically learned deep neural network as an energy based model that can be processed on a one-step quantum annealer in order to exploit fast sampling times. We propose approaches to overcome two…

Quantum Physics · Physics 2021-07-20 Catherine F. Higham , Adrian Bedford

The recent emergence of novel computational devices, such as quantum computers, coherent Ising machines, and digital annealers presents new opportunities for hardware-accelerated hybrid optimization algorithms. Unfortunately, demonstrations…

Optimization and Control · Mathematics 2020-10-21 Yuchen Pang , Carleton Coffrin , Andrey Y. Lokhov , Marc Vuffray

Recent developments in quantum annealing techniques have been indicating potential advantage of quantum annealing for solving NP-hard optimization problems. In this article we briefly indicate and discuss the beneficial features of quantum…

Statistical Mechanics · Physics 2015-06-22 Sudip Mukherjee , Bikas K. Chakrabarti

I describe how real quantum annealers may be used to perform local (in state space) searches around specified states, rather than the global searches traditionally implemented in the quantum annealing algorithm. The quantum annealing…

Emerging Technologies · Computer Science 2016-06-23 Nicholas Chancellor

Drawing independent samples from high-dimensional probability distributions represents the major computational bottleneck for modern algorithms, including powerful machine learning frameworks such as deep learning. The quest for discovering…

Quantum Physics · Physics 2022-10-13 Marc Vuffray , Carleton Coffrin , Yaroslav A. Kharkov , Andrey Y. Lokhov

The Closest String Problem is an NP-complete problem which appears more commonly in bioinformatics and coding theory. Less surprisingly, classical approaches have been pursued with two prominent algorithms being the genetic algorithm and…

Quantum Physics · Physics 2023-10-20 Chandeepa Dissanayake

Feature selection is a common step in many ranking, classification, or prediction tasks and serves many purposes. By removing redundant or noisy features, the accuracy of ranking or classification can be improved and the computational cost…

Information Retrieval · Computer Science 2022-05-10 Maurizio Ferrari Dacrema , Fabio Moroni , Riccardo Nembrini , Nicola Ferro , Guglielmo Faggioli , Paolo Cremonesi

With the advent of novel quantum computing technologies, and the knowledge that such technology might be used to fundamentally change computing applications, a prime opportunity has presented itself to investigate the practical application…

Computational Engineering, Finance, and Science · Computer Science 2024-02-13 Kevin Wils , Boyang Chen

We introduce a novel approach to solving dynamic programming problems, such as those in many economic models, on a quantum annealer, a specialized device that performs combinatorial optimization. Quantum annealers attempt to solve an…

General Economics · Economics 2023-06-08 Jesús Fernández-Villaverde , Isaiah Hull

Quantum annealing (QA) has the potential to significantly improve solution quality and reduce time complexity in solving combinatorial optimization problems compared to classical optimization methods. However, due to the limited number of…

Quantum Physics · Physics 2025-04-09 Seongmin Kim , Sang-Woo Ahn , In-Saeng Suh , Alexander W. Dowling , Eungkyu Lee , Tengfei Luo

The observation of an unequivocal quantum speedup remains an elusive objective for quantum computing. The D-Wave quantum annealing processors have been at the forefront of experimental attempts to address this goal, given their relatively…

Quantum Physics · Physics 2018-08-08 Tameem Albash , Daniel A. Lidar

Training of machine learning models consumes large amounts of energy. Since the energy consumption becomes a major problem in the development and implementation of artificial intelligence systems there exists a need to investigate the ways…

Quantum Physics · Physics 2025-09-03 Dawid Mazur , Tomasz Rybotycki , Piotr Gawron

Many problems of industrial interest are NP-complete, and quickly exhaust resources of computational devices with increasing input sizes. Quantum annealers (QA) are physical devices that aim at this class of problems by exploiting quantum…

We propose a novel method for reducing the number of variables in quadratic unconstrained binary optimization problems, using a quantum annealer (or any sampler) to fix the value of a large portion of the variables to values that have a…

Quantum Physics · Physics 2017-09-26 Hamed Karimi , Gili Rosenberg

Quantum annealing allows for quantum fluctuations to be used used to assist in finding the solution to some of the worlds most challenging computational problems. Recently, this field has attracted much interest because of the construction…

Quantum Physics · Physics 2022-07-26 Nicholas Chancellor

Quantum annealing is a heuristic optimization algorithm that exploits quantum evolution to approximately find lowest energy states. Quantum annealers have scaled up in recent years to tackle increasingly larger and more highly connected…

Quantum Physics · Physics 2025-07-04 Humberto Munoz Bauza , Daniel A. Lidar
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