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Molecular property prediction (MPP) is a fundamental and crucial task in drug discovery. However, prior methods are limited by the requirement for a large number of labeled molecules and their restricted ability to generalize for unseen and…

Quantitative Methods · Quantitative Biology 2024-10-21 Yuyan Liu , Sirui Ding , Sheng Zhou , Wenqi Fan , Qiaoyu Tan

Few-shot molecular property prediction (FSMPP) is essential in drug discovery and materials design, where high-quality labeled data are often scarce and expensive to obtain. Despite the promising performance of existing methods, especially…

Computational Engineering, Finance, and Science · Computer Science 2026-05-14 Zeyu Wang , Xin Zheng , Yao Lu , Shanqing Yu , Qi Xuan , Shirui Pan

We consider feature representation learning problem of molecular graphs. Graph Neural Networks have been widely used in feature representation learning of molecular graphs. However, most existing methods deal with molecular graphs…

Machine Learning · Computer Science 2022-06-08 Zhaoning Yu , Hongyang Gao

While graph neural networks have shown remarkable success in molecular property prediction, current approaches like the Equivariant Subgraph Aggregation Networks (ESAN) treat molecules as bags of independent substructures, overlooking…

Machine Learning · Computer Science 2025-12-16 Shuhui Qu , Cheolwoo Park

AI-assisted molecular property prediction has become a promising technique in early-stage drug discovery and materials design in recent years. However, due to high-cost and complex wet-lab experiments, real-world molecules usually…

Computational Engineering, Finance, and Science · Computer Science 2025-10-13 Zeyu Wang , Tianyi Jiang , Huanchang Ma , Yao Lu , Xiaoze Bao , Shanqing Yu , Qi Xuan , Shirui Pan , Xin Zheng

Machine learning-driven methods for property prediction have been of deep interest. However, much work remains to be done to improve the generalization ability, accuracy, and inference time for critical applications. The traditional machine…

Quantitative Methods · Quantitative Biology 2024-10-08 Kanad Sen , Saksham Gupta , Abhishek Raj , Alankar Alankar

Molecular property prediction is essential in a variety of contemporary scientific fields, such as drug development and designing energy storage materials. Although there are many machine learning models available for this purpose, those…

Machine Learning · Computer Science 2025-06-03 Gihan Panapitiya , Peiyuan Gao , C Mark Maupin , Emily G Saldanha

In the field of chemistry, the objective is to create novel molecules with desired properties, facilitating accurate property predictions for applications such as material design and drug screening. However, existing graph deep learning…

Machine Learning · Computer Science 2024-08-28 Sakhinana Sagar Srinivas , Venkataramana Runkana

Graph classification is a highly impactful task that plays a crucial role in a myriad of real-world applications such as molecular property prediction and protein function prediction.Aiming to handle the new classes with limited labeled…

Machine Learning · Computer Science 2021-12-30 Shunyu Jiang , Fuli Feng , Weijian Chen , Xiang Li , Xiangnan He

Node classification is an essential problem in graph learning. However, many models typically obtain unsatisfactory performance when applied to few-shot scenarios. Some studies have attempted to combine meta-learning with graph neural…

Machine Learning · Computer Science 2024-07-23 Yonghao Liu , Mengyu Li , Ximing Li , Lan Huang , Fausto Giunchiglia , Yanchun Liang , Xiaoyue Feng , Renchu Guan

Designing accurate deep learning models for molecular property prediction plays an increasingly essential role in drug and material discovery. Recently, due to the scarcity of labeled molecules, self-supervised learning methods for learning…

Biomolecules · Quantitative Biology 2022-06-08 Han Li , Dan Zhao , Jianyang Zeng

Graph neural networks are currently leading the performance charts in learning-based molecule property prediction and classification. Computational chemistry has, therefore, become the a prominent testbed for generic graph neural networks,…

Machine Learning · Computer Science 2020-02-04 Eliya Nachmani , Lior Wolf

Molecular representation learning is a crucial task in predicting molecular properties. Molecules are often modeled as graphs where atoms and chemical bonds are represented as nodes and edges, respectively, and Graph Neural Networks (GNNs)…

Machine Learning · Computer Science 2023-05-23 Jiahao Chen , Yurou Liu , Jiangmeng Li , Bing Su , Jirong Wen

Deep graph generative modeling has gained enormous attraction in recent years due to its impressive ability to directly learn the underlying hidden graph distribution. Despite their initial success, these techniques, like much of the…

Machine Learning · Computer Science 2023-12-15 Sahil Manchanda , Shubham Gupta , Sayan Ranu , Srikanta Bedathur

Molecular property prediction is of crucial importance in many disciplines such as drug discovery, molecular biology, or material and process design. The frequently employed quantitative structure-property/activity relationships…

Biomolecules · Quantitative Biology 2024-01-17 Jan G. Rittig , Qinghe Gao , Manuel Dahmen , Alexander Mitsos , Artur M. Schweidtmann

Molecular property prediction plays a fundamental role in drug discovery to identify candidate molecules with target properties. However, molecular property prediction is essentially a few-shot problem which makes it hard to use regular…

Machine Learning · Computer Science 2021-11-12 Yaqing Wang , Abulikemu Abuduweili , Quanming Yao , Dejing Dou

The crux of molecular property prediction is to generate meaningful representations of the molecules. One promising route is to exploit the molecular graph structure through Graph Neural Networks (GNNs). It is well known that both atoms and…

Quantitative Methods · Quantitative Biology 2020-06-15 Hehuan Ma , Yatao Bian , Yu Rong , Wenbing Huang , Tingyang Xu , Weiyang Xie , Geyan Ye , Junzhou Huang

Predicting molecular properties (e.g., atomization energy) is an essential issue in quantum chemistry, which could speed up much research progress, such as drug designing and substance discovery. Traditional studies based on density…

Computational Physics · Physics 2019-08-20 Chengqiang Lu , Qi Liu , Chao Wang , Zhenya Huang , Peize Lin , Lixin He

The ability to reason over learned knowledge is an innate ability for humans and humans can easily master new reasoning rules with only a few demonstrations. While most existing studies on knowledge graph (KG) reasoning assume enough…

Computation and Language · Computer Science 2019-08-15 Hong Wang , Wenhan Xiong , Mo Yu , Xiaoxiao Guo , Shiyu Chang , William Yang Wang

Attributed networks nowadays are ubiquitous in a myriad of high-impact applications, such as social network analysis, financial fraud detection, and drug discovery. As a central analytical task on attributed networks, node classification…

Machine Learning · Computer Science 2020-11-30 Kaize Ding , Jianling Wang , Jundong Li , Kai Shu , Chenghao Liu , Huan Liu