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In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Magdalini Paschali , Muhammad Ferjad Naeem , Walter Simson , Katja Steiger , Martin Mollenhauer , Nassir Navab

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Baizhi Wang , Rui Yan , Wenxin Ma , Xu Zhang , Yuhao Wang , Xiaolong Li , Yunjie Gu , Zihang Jiang , S. Kevin Zhou

The realm of Weakly Supervised Instance Segmentation (WSIS) under box supervision has garnered substantial attention, showcasing remarkable advancements in recent years. However, the limitations of box supervision become apparent in its…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Xinyi Yu , Ling Yan , Pengtao Jiang , Hao Chen , Bo Li , Lin Yuanbo Wu , Linlin Ou

Histology analysis of the tumor micro-environment integrated with genomic assays is the gold standard for most cancers in modern medicine. This paper proposes a Gene-induced Multimodal Pre-training (GiMP) framework, which jointly…

Computer Vision and Pattern Recognition · Computer Science 2023-09-07 Ting Jin , Xingran Xie , Renjie Wan , Qingli Li , Yan Wang

This paper presents a supervised mixing augmentation method termed SuperMix, which exploits the salient regions within input images to construct mixed training samples. SuperMix is designed to obtain mixed images rich in visual features and…

Computer Vision and Pattern Recognition · Computer Science 2021-12-13 Ali Dabouei , Sobhan Soleymani , Fariborz Taherkhani , Nasser M. Nasrabadi

Lifelong learning on Whole Slide Images (WSIs) aims to train or fine-tune a unified model sequentially on cancer-related tasks, reducing the resources and effort required for data transfer and processing, especially given the gigabyte-scale…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Doanh C. Bui , Ba Hung Ngo , Hoai Luan Pham , Khang Nguyen , Maï K. Nguyen , Yasuhiko Nakashima

A major drawback of supervised speech separation (SSep) systems is their reliance on synthetic data, leading to poor real-world generalization. Mixture invariant training (MixIT) was proposed as an unsupervised alternative that uses real…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-22 Joonas Kalda , Clément Pagés , Ricard Marxer , Tanel Alumäe , Hervé Bredin

Learning from label proportions (LLP) is a promising weakly supervised learning problem. In LLP, a set of instances (bag) has label proportions, but no instance-level labels are given. LLP aims to train an instance-level classifier by using…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Takanori Asanomi , Shinnosuke Matsuo , Daiki Suehiro , Ryoma Bise

The state of the art in semantic segmentation is steadily increasing in performance, resulting in more precise and reliable segmentations in many different applications. However, progress is limited by the cost of generating labels for…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Viktor Olsson , Wilhelm Tranheden , Juliano Pinto , Lennart Svensson

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with…

Image and Video Processing · Electrical Eng. & Systems 2026-03-23 Lubin Gan , Jing Zhang , Heng Zhang , Xin Di , Zhifeng Wang , Wenke Huang , Xiaoyan Sun

This work studies Hyperspectral image (HSI) super-resolution (SR). HSI SR is characterized by high-dimensional data and a limited amount of training examples. This exacerbates the undesirable behaviors of neural networks such as…

Computer Vision and Pattern Recognition · Computer Science 2021-04-06 Ke Li , Dengxin Dai , Ender Konukoglu , Luc Van Gool

Semi-Supervised Instance Segmentation (SSIS) involves classifying and grouping image pixels into distinct object instances using limited labeled data. This learning paradigm usually faces a significant challenge of unstable performance…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Jianghang Lin , Yilin Lu , Yunhang Shen , Chaoyang Zhu , Shengchuan Zhang , Liujuan Cao , Rongrong Ji

Data augmentation techniques play an important role in enhancing the performance of deep learning models. Despite their proven benefits in computer vision tasks, their application in the other domains remains limited. This paper proposes a…

Machine Learning · Computer Science 2024-01-23 Yousef El-Laham , Elizabeth Fons , Dillon Daudert , Svitlana Vyetrenko

Modern machine learning pipelines are increasingly combining and mixing data from diverse and disparate sources, e.g., pre-training large language models. Yet, finding the optimal data mixture is a challenging and open problem. We formalize…

Machine Learning · Computer Science 2026-01-16 Anvith Thudi , Evianne Rovers , Yangjun Ruan , Tristan Thrush , Chris J. Maddison

Mixup is a popular data augmentation technique for training deep neural networks where additional samples are generated by linearly interpolating pairs of inputs and their labels. This technique is known to improve the generalization…

Machine Learning · Computer Science 2023-10-17 Yingtian Zou , Vikas Verma , Sarthak Mittal , Wai Hoh Tang , Hieu Pham , Juho Kannala , Yoshua Bengio , Arno Solin , Kenji Kawaguchi

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

The rise in internet usage has led to the generation of massive amounts of data, resulting in the adoption of various supervised and semi-supervised machine learning algorithms, which can effectively utilize the colossal amount of data to…

Multi-instance learning (MIL) is a form of weakly supervised learning where a single class label is assigned to a bag of instances while the instance-level labels are not available. Training classifiers to accurately determine the bag label…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Bin Li , Kevin W. Eliceiri

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He