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Current density distributions in active integrated circuits (ICs) result in patterns of magnetic fields that contain structural and functional information about the IC. Magnetic fields pass through standard materials used by the…

Quantum diamond magnetometers using lock-in detection have successfully detected weak bio-magnetic fields from neurons, a live mammalian muscle, and a live mouse heart. This opens up the possibility of quantum diamond magnetometers…

Quantum Physics · Physics 2023-07-04 Sangwon Oh , Seong-Joo Lee , Jeong Hyun Shim , Nam Woong Song , Truong Thi Hien

The increasing complexity of advanced semiconductor packages, driven by chiplet architectures and 2.5D/3D integration, challenges conventional failure localization methods such as lock-in thermography (LIT) and complicates current Failure…

Quantum Physics · Physics 2025-12-09 Bartu Bisgin , Marwa Garsi , Andreas Welscher , Michael Hanke , Fleming Bruckmaier

Transmission electron microscopy (TEM) can be used to successfully determine the structures of proteins. However, such studies are typically done ex situ after extraction of the protein from the cellular environment. Here we describe an…

Biological Physics · Physics 2017-11-07 Michael P. Lake , Louis-S. Bouchard

DNA flexibility is a key determinant of biological function, from nucleosome positioning to transcriptional regulation, motivating a direct measurement of the bend-torque response of individual DNA molecules. In this work, DNA bending is…

We report an acoustic approach to measure the elastic properties of an extracellular matrix (ECM). This approach uses a short range evanescent waves to inject sound into the test material over a short distance using an electroded quartz…

Biological Physics · Physics 2018-01-03 Jenny Overton , Arthur Kissin , William Bains , Adrian Stevenson

The quartz crystal microbalance (QCM) is widely used to study surface adsorbed molecules, often of biological significance. However, the relation between raw acoustic response (frequency shift $\Delta f$ and dissipation factor $\Delta D$)…

We report the details of construction and testing of a Quantum Twisting Microscope, a recently developed scanning probe instrument that enables twist angle dependent electronic measurements on layered materials. Our implementation is based…

Mesoscale and Nanoscale Physics · Physics 2026-04-07 Sayanwita Biswas , Ranjani Ramachandran , Patrick Irvin , Jeremy Levy

Widefield quantum diamond microscopy (WQDM) based on Kohler-illumination has been widely adopted in the field of quantum sensing, however, practical applications are still limited by issues such as unavoidable photodamage and unsatisfied…

Optics · Physics 2023-07-28 Feng Xu , Jialong Chen , Yong Hou , Juan Cheng , Tony KC Hui , Shih-Chi Chen , Zhiqin Chu

Molecular adhesion plays a central role in many biological systems, yet existing methods to quantify adhesive strength often struggle to bridge the gap between single-molecule resolution and biologically relevant environments. Here, we…

The precise measurement of mechanical stress at the nanoscale is of fundamental and technological importance. In principle, all six independent variables of the stress tensor, which describe the direction and magnitude of…

The projected rapid growth of battery cell production over the next decade demands advanced diagnostic tools for quality control, ageing prediction, and recycling. Most existing techniques lack the spatial and temporal resolution required…

In vivo, eukaryotic cells are embedded in a matrix environment, where they grow and develop. Generally, this extracellular matrix (ECM) is an anisotropic fibrous structure, through which macromolecules and biochemical signaling molecules at…

Biological Physics · Physics 2020-01-06 David Gomez , Sari Natan , Yair Shokef , Ayelet Lesman

A quantitative and predictive theory of quantum light-matter interactions in ultra thin materials involves several fundamental challenges. Any realistic model must simultaneously account for the ultra-confined plasmonic modes and their…

Atomic Force Microscopy (AFM) has a great potential as a tool to characterize mechanical and morphological properties of living cells; these properties have been shown to correlate with cells' fate and patho-physiological state in view of…

Soft Condensed Matter · Physics 2017-06-21 Luca Puricelli , Massimiliano Galluzzi , Carsten Schulte , Alessandro Podestà , Paolo Milani

The adoption of 3D packaging technology necessitates the development of new approaches to failure electronic device analysis. To that end, our team is developing a tool called the quantum diamond microscope (QDM) that leverages an ensemble…

As integrated circuit (IC) geometry and packaging become more sophisticated with ongoing fabrication and design innovations, the electrical engineering community needs increasingly-powerful failure analysis (FA) methods to meet the growing…

Instrumentation and Detectors · Physics 2023-07-20 P. Kehayias , J. Walraven , A. L. Rodarte , A. M. Mounce

We present a novel technique for determining the microscale AC susceptibility of magnetic materials. We use magnetic field sensing properties of nitrogen-vacancy (\ce{NV-}) centers in diamond to gather quantitative data about the magnetic…

Applied Physics · Physics 2023-05-17 Shishir Dasika , Madhur Parashar , Kasturi Saha

Cell cell and cell matrix adhesions are fundamental in all multicellular organisms. They play a key role in cellular growth, differentiation, pattern formation and migration. Cell-cell adhesion is substantial in the immune response,…

Biological Physics · Physics 2019-05-30 Rita Ungai-Salanki , Beatrix Peter , Tamas Gerecsei , Norbert Orgovan , Robert Horvath , Balint Szabo

Interactions between atomic and molecular objects are to a large extent defined by the nanoscale electrostatic potentials which these objects produce. We introduce a scanning probe technique that enables three-dimensional imaging of local…