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Recent years have seen rapid progress at the intersection between causality and machine learning. Motivated by scientific applications involving high-dimensional data, in particular in biomedicine, we propose a deep neural architecture for…

Machine Learning · Computer Science 2022-12-12 Kai Lagemann , Christian Lagemann , Bernd Taschler , Sach Mukherjee

Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in…

Machine Learning · Statistics 2017-10-31 Dustin Tran , David M. Blei

Structural causal models are the basic modelling unit in Pearl's causal theory; in principle they allow us to solve counterfactuals, which are at the top rung of the ladder of causation. But they often contain latent variables that limit…

Artificial Intelligence · Computer Science 2021-11-23 Marco Zaffalon , Alessandro Antonucci , Rafael Cabañas

Causal generative modelling is gaining interest in medical imaging due to its ability to answer interventional and counterfactual queries. Most work focuses on generating counterfactual images that look plausible, using auxiliary…

Computer Vision and Pattern Recognition · Computer Science 2024-03-15 Tian Xia , Mélanie Roschewitz , Fabio De Sousa Ribeiro , Charles Jones , Ben Glocker

Estimating an individual's potential outcomes under counterfactual treatments is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, impulse…

Machine Learning · Statistics 2025-02-13 Yulun Wu , Layne C. Price , Zichen Wang , Vassilis N. Ioannidis , Robert A. Barton , George Karypis

We introduce new inference procedures for counterfactual and synthetic control methods for policy evaluation. We recast the causal inference problem as a counterfactual prediction and a structural breaks testing problem. This allows us to…

Econometrics · Economics 2022-01-26 Victor Chernozhukov , Kaspar Wüthrich , Yinchu Zhu

Image captioning, which generates natural language descriptions of the visual information in an image, is a crucial task in vision-language research. Previous models have typically addressed this task by aligning the generative capabilities…

Computer Vision and Pattern Recognition · Computer Science 2024-09-02 Qian Cao , Xu Chen , Ruihua Song , Xiting Wang , Xinting Huang , Yuchen Ren

We introduce an approach to counterfactual inference based on merging information from multiple datasets. We consider a causal reformulation of the statistical marginal problem: given a collection of marginal structural causal models (SCMs)…

Artificial Intelligence · Computer Science 2022-07-18 Luigi Gresele , Julius von Kügelgen , Jonas M. Kübler , Elke Kirschbaum , Bernhard Schölkopf , Dominik Janzing

Counterfactuals answer questions of what would have been observed under altered circumstances and can therefore offer valuable insights. Whereas the classical interventional interpretation of counterfactuals has been studied extensively,…

Artificial Intelligence · Computer Science 2024-08-13 Klaus-Rudolf Kladny , Julius von Kügelgen , Bernhard Schölkopf , Michael Muehlebach

The number of samples in structural brain MRI studies is often too small to properly train deep learning models. Generative models show promise in addressing this issue by effectively learning the data distribution and generating…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Wei Peng , Tian Xia , Fabio De Sousa Ribeiro , Tomas Bosschieter , Ehsan Adeli , Qingyu Zhao , Ben Glocker , Kilian M. Pohl

In this paper, we propose leveraging causal generative learning as an interpretable tool for explaining image classifiers. Specifically, we present a generative counterfactual inference approach to study the influence of visual features…

Machine Learning · Computer Science 2024-01-23 Will Taylor-Melanson , Zahra Sadeghi , Stan Matwin

Estimating the counterfactual outcome of treatment is essential for decision-making in public health and clinical science, among others. Often, treatments are administered in a sequential, time-varying manner, leading to an exponentially…

Machine Learning · Statistics 2024-07-16 Shenghao Wu , Wenbin Zhou , Minshuo Chen , Shixiang Zhu

Despite the increasing effectiveness of language models, their reasoning capabilities remain underdeveloped. In particular, causal reasoning through counterfactual question answering is lacking. This work aims to bridge this gap. We first…

Computation and Language · Computer Science 2025-03-18 Alihan Hüyük , Xinnuo Xu , Jacqueline Maasch , Aditya V. Nori , Javier González

Referred to as the third rung of the causal inference ladder, counterfactual queries typically ask the "What if ?" question retrospectively. The standard approach to estimate counterfactuals resides in using a structural equation model that…

Machine Learning · Computer Science 2023-01-18 Edward De Brouwer

Evaluation of counterfactual queries (e.g., "If A were true, would C have been true?") is important to fault diagnosis, planning, determination of liability, and policy analysis. We present a method of revaluating counterfactuals when the…

Artificial Intelligence · Computer Science 2013-02-21 Alexander Balke , Judea Pearl

Inferring the effect of interventions within complex systems is a fundamental problem of statistics. A widely studied approach employs structural causal models that postulate noisy functional relations among a set of interacting variables.…

Methodology · Statistics 2024-02-14 David Strieder , Mathias Drton

Answering counterfactual queries has important applications such as explainability, robustness, and fairness but is challenging when the causal variables are unobserved and the observations are non-linear mixtures of these latent variables,…

Machine Learning · Computer Science 2024-04-16 Zeyu Zhou , Ruqi Bai , Sean Kulinski , Murat Kocaoglu , David I. Inouye

We assume to be given structural equations over discrete variables inducing a directed acyclic graph, namely, a structural causal model, together with data about its internal nodes. The question we want to answer is how we can compute…

Artificial Intelligence · Computer Science 2023-12-05 Marco Zaffalon , Alessandro Antonucci , Rafael Cabañas , David Huber , Dario Azzimonti

Automated decision support systems that are able to infer second opinions from experts can potentially facilitate a more efficient allocation of resources; they can help decide when and from whom to seek a second opinion. In this paper, we…

Machine Learning · Computer Science 2022-07-01 Nina L. Corvelo Benz , Manuel Gomez Rodriguez

We hypothesize that optimal system responses emerge from adaptive strategies grounded in causal and counterfactual knowledge. Counterfactual inference allows us to create hypothetical scenarios to examine the effects of alternative system…

Human-Computer Interaction · Computer Science 2025-05-29 Donghuo Zeng , Roberto Legaspi , Yuewen Sun , Xinshuai Dong , Kazushi Ikeda , Peter Spirtes , Kun Zhang