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Fluorescence lifetime imaging (FLI) is an important technique for studying cellular environments and molecular interactions, but its real-time application is limited by slow data acquisition, which requires capturing large time-resolved…
Fluorescence lifetime imaging (FLI) is a widely used technique in the biomedical field for measuring the decay times of fluorescent molecules, providing insights into metabolic states, protein interactions, and ligand-receptor bindings.…
Compressive Macroscopic Fluorescence Lifetime Imaging (MFLI) is a novel technical implementation that enables monitoring multiple molecular interactions in macroscopic scale. Especially, we reported recently on the development of a…
Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…
This paper reported a bespoke adder-based deep learning network for time-domain fluorescence lifetime imaging (FLIM). By leveraging the l1-norm extraction method, we propose a 1-D Fluorescence Lifetime AdderNet (FLAN) without…
Fluorescence Lifetime Imaging (FLI) is a critical molecular imaging modality that provides unique information about the tissue microenvironment, which is invaluable for biomedical applications. FLI operates by acquiring and analyzing photon…
Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising…
Photoluminesce (PL) spectroscopy offers excellent methods for mapping the PL decay on the nanosecond time scale. However, capturing maps of emission dynamics on the microsecond time scale can be highly time-consuming. We present a new…
Recurrent Neural Networks (RNNs) have been widely applied to deal with temporal problems, such as flood forecasting and financial data processing. On the one hand, traditional RNNs models amplify the gradient issue due to the strict time…
RAndom Temporal Signals (RATS) method has proven to be a useful and versatile method for measuring photoluminescence (PL) dynamics and fluorescence lifetime imaging (FLIM). Here, we present two fundamental development steps in the method.…
Generating eye diagrams by using a circuit simulator can be very computationally intensive, especially in the presence of nonlinearities. It often involves multiple Newton-like iterations at every time step when a SPICE-like circuit…
Neuromorphic Computing implemented in photonic hardware is one of the most promising routes towards achieving machine learning processing at the picosecond scale, with minimum power consumption. In this work, we present a new concept for…
Imaging across both the full transverse spatial and temporal dimensions of a scene with high precision in all three coordinates is key to applications ranging from LIDAR to fluorescence lifetime imaging. However, compromises that sacrifice,…
We present an experimental imaging flow cytometer using a 1 {\mu}s temporal resolution event-based CMOS camera, with data processed by adaptive feedforward and recurrent spiking neural networks. Our study classifies PMMA particles (12, 16,…
Video super-resolution (VSR) is the task of restoring high-resolution frames from a sequence of low-resolution inputs. Different from single image super-resolution, VSR can utilize frames' temporal information to reconstruct results with…
We report the development and detailed calibration of a multiphoton fluorescence lifetime imaging system (FLIM) using a streak camera. The present system is versatile with high spatial (0.2 micron) and temporal (50 psec) resolution and…
High-resolution magnetic resonance imaging (MRI) is essential in clinical diagnosis. However, its long acquisition time remains a critical issue. Parallel imaging (PI) is a common approach to reduce acquisition time by periodically skipping…
Diffusion models (DMs) have demonstrated remarkable success in real-world image super-resolution (SR), yet their reliance on time-consuming multi-step sampling largely hinders their practical applications. While recent efforts have…
With the rise of Extended Reality (XR) technology, there is a growing need for real-time light field reconstruction from sparse view inputs. Existing methods can be classified into offline techniques, which can generate high-quality novel…
Dual-view snapshot compressive imaging (SCI) aims to capture videos from two field-of-views (FoVs) using a 2D sensor (detector) in a single snapshot, achieving joint FoV and temporal compressive sensing, and thus enjoying the advantages of…